The anticarcinogenic effect of propolis in human lymphocytes culture

Özkul, Yusuf; Silici, Sibel; Eroğlu, Eray

doi:10.1016/j.phymed.2004.06.015

Cited by 48 publications

(35 citation statements)

References 28 publications

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“…A composição química da própolis inclui fl avonóides (como a galangina, quercetina, pinocembrina e kaempferol), ácidos aromáticos e ésteres, aldeídos e cetonas, terpenóides e fenilpropanóides (como os ácidos caféico e clorogênico), esteróides, aminoácidos, polissacarídeos, hidrocarbonetos, ácidos graxos e vários outros compostos em pequenas quantidades Hayacibara et al, 2005;Ozkul et al, 2004;Matsuda et al, 2002;Rocha et al, 2003). Há também na sua constituição elementos inorgânicos como o cobre, manganês, ferro, cálcio, alumínio, vanádio e silício (Marcucci, 1996).…”

Section: Composição Químicaunclassified

Própolis: atualizações sobre a química e a farmacologia

Lustosa¹,

Galindo²,

Nunes³

et al. 2008

Rev. bras. farmacogn.

114

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RESUMO:Própolis é uma mistura complexa, formada por material resinoso e balsâmico. Sua composição química é complexa e variada, estando relacionada com a fl ora de cada região visitada pelas abelhas e com o período de coleta da resina. Inclui fl avonóides, ácidos aromáticos, terpenóides e fenilpropanóides, ácidos graxos e vários outros compostos. A própolis tem sido objeto de intensos estudos farmacológicos e químicos nos últimos 30 anos. Em várias partes do mundo é indicada para melhorar a saúde e prevenir doenças. Atualmente, é disponível em várias formas farmacêuticas como cápsulas, extratos, enxaguatório bucal, na forma de pó, entre outras. Ainda são necessários estudos correlacionando a composição química com a atividade biológica, defi nindo cada tipo de própolis com a sua aplicação terapêutica. É uma tarefa imprescindível para um mercado cada vez maior e exigente em todo o mundo.Unitermos: Própolis, constituintes químicos, atividade biológica.ABSTRACT: "Propolis: updates on chemistry and pharmacology". Propolis (bee glue) is a complex mixture, formed by resinous and balsamic material. Its chemical composition is variable and complex, being related with the fl ora of each region visited by the bees and with the period of resins collection. Flavonoids, aromatic acids, terpenoids and phenylpropanoids, fatty acids, and other compounds are found in propolis. In the last 30 years, propolis has become subject of intense pharmacological and chemical studies. In different parts of the world it is indicated to improve health and prevent illnesses. Currently, it is available in some pharmaceutical forms as capsules, extracts, mouthrinses, powder form, among others. Indeed, studies correlating the chemical composition with the biological activity are necessary, defi ning each type of propolis with its therapeutic application. It is an essential task for a market ever bigger and demanding in the whole word.

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Section: Composição Químicaunclassified

Própolis: atualizações sobre a química e a farmacologia

Lustosa¹,

Galindo²,

Nunes³

et al. 2008

Rev. bras. farmacogn.

114

View full text Add to dashboard Cite

show abstract

“…Ethanolic extract of Turkish propolis (PEE) collected from various areas show multi-properties activity as antibacterial (Keskin et al, 2001;Ozcan et al, 2004), antifungal (Koc et al, 2005), antioxidant (Kolankaya et al, 2002;Orhan et al, 1999) and anticarcinogenic (Ozkul et al, 2005). The chemicals compounds in propolis and biological activities depend on different factors such as the geographical regions, collection time and plant source (Bankova, 2005;Hegazi et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Efficacy Evaluation of Iraqi Propolis Against Gray Mold of Stored Orange Caused by Penicillium digitatum

Matny¹

2015

Plant Pathology J.

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A B S T R A C T This study was conducted to evaluate Iraqi propolis against gray mold on orange. Propolis Ethanolic Extract (PEE) in three concentrations 1, 2 and 3% were used to treated orange treatments separately and storage at 25±2°C for three weeks. Results showed a significant reduced in disease severity in the first, second and third week for all PEE concentrations compared with infected control. The best treatment was 3% in disease severity reduction. Disease incidence was significantly reduced with the treatment treated with PEE for all concentrations compared with the pathogen treatment, both concentration of PEE 2 and 3% was the most effective. Also, all PEE concentrations reduce depth of the mold area compared with pathogen treatment. There are no significant differences in patulin production between PEE and pathogen treatments was founded.

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“…The fixation step was repeated three times. Slides were air-dried and stained with 5% Giemsa [24]. Mitotic Index was calculated as the proportion of metaphase for 1000 cells as shown below:…”

Section: Mitotic Index Assay On Pc-3 Cellsmentioning

confidence: 99%

Acacia Honey Modulates Cell Cycle Progression, Pro-inflammatory Cytokines and Calcium Ions Secretion in PC-3 Cell Lines

et al. 2012

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Background: Prostate cancer is the most common malignancy in men and the second leading cause of cancer-related deaths. Honey has been proven to have a potentiality of being among the functional foods by both in vivo and in vitro studies. Aim:This study was primarily designed to provide evidence on the apoptotic role of acacia honey on PC-3 cell line. Methods:MTT and mitotic index assay were used to determine the anti-proliferative effects. Cell cycle analysis was conducted on flow cytometer using propidium iodide. Expression of pro-inflammatory cytokines [TNF α and IL 1β] and prostate specific antigen were determined by ELISA kits. Calcium ion level was analyzed by colorimetric method. Results:Our results show the anti-proliferative effects of acacia honey on NIH/3T3 and PC-3 cell lines with the IC 50 of 3.7 and 1.9% [v/v] respectively with simultaneous increase in the secretion of calcium ion and down regulation of prostate specific antigen. Significant [p < 0.05] dose-dependent modulation of G0/G1 phase was observed as compared with the control. However, there was an inverse relationship between TNF-α and IL-1β with latter being up regulated. Mitotic index of PC-3 cells decreased as the concentration of honey increases. Conclusion:Apoptotic role of acacia honey on PC-3 cell line may be due to modulation of G0/G1 phase, proinflammatory cytokines, calcium ions secretion and down regulation of prostate specific antigen in vitro.

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The anticarcinogenic effect of propolis in human lymphocytes culture

Cited by 48 publications

References 28 publications

Própolis: atualizações sobre a química e a farmacologia

Própolis: atualizações sobre a química e a farmacologia

Efficacy Evaluation of Iraqi Propolis Against Gray Mold of Stored Orange Caused by Penicillium digitatum

Acacia Honey Modulates Cell Cycle Progression, Pro-inflammatory Cytokines and Calcium Ions Secretion in PC-3 Cell Lines

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