2007
DOI: 10.1097/mbc.0b013e3280121c5e
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The anticoagulant capacity of plasmatic unfractionated heparin decreases at 23°C

Abstract: Unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH) are important clinical anticoagulants. As polynegative molecules they are potential triggers of the contact phase of coagulation. An incubation temperature lower than the physiological 37 degrees C favours intrinsic haemostasis activation by the polynegative molecule SiO2. The efficiency of UFH and LMWH after a plasmatic preincubation at 37 or at 23 degrees C is therefore studied. Samples (150 mul) of unfrozen pooled normal plasma supplemente… Show more

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“…2e) -but if the pooled normal citrated plasma is supplemented directly out of the original vial, intermediate dilutions in polystyrol tubes may alter the efficiency of heparins [29]. Figure 2e demonstrates also that the LMWHs have different activities, enoxaparin being superior to certoparin or to this lot of dalteparin.…”
Section: Figures 2-7 Andmentioning
confidence: 95%
“…2e) -but if the pooled normal citrated plasma is supplemented directly out of the original vial, intermediate dilutions in polystyrol tubes may alter the efficiency of heparins [29]. Figure 2e demonstrates also that the LMWHs have different activities, enoxaparin being superior to certoparin or to this lot of dalteparin.…”
Section: Figures 2-7 Andmentioning
confidence: 95%