The anticorrosion mechanism of phenolic conversion coating applied on magnesium implants

Chen, Si; Zhao, Sheng; Zhang, Xuan; Jiang, Zhang; Li, Xin; Zhang, Hao; Shen, Xiaolong; Wang, Jin; Huang, Nan

doi:10.1016/j.apsusc.2018.08.261

Cited by 44 publications

(14 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many studies have investigated the use of phenolic molecules to regulate endothelialization based on their specific properties on SMCs and ECs [28,29]. These applications not only prevent the over-growth of SMCs from invading the EC wall but also assist in the formation of a uniform endothelial layer in the vascular system.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, a free radical scavenging analysis completed by DPPH was conducted to evaluate the antioxidant capacity of the stent platform [34]. Phenolic molecules, such as ECGC and TA [28][29][30][31], have been discussed in similar studies, yet the GA application under PLGA eluting stents has not been sufficiently investigated. In our previous study, a phenolic-modified ceramic coating on ZK60 was proven to be efficient on osteo-like cell activity [12].…”

Section: Discussionmentioning

confidence: 99%

“…Since cellular antioxidants prevent the formation of oxidized low-density lipoprotein (LDL) and antiplatelet activation, this is a remarkable method by which to treat atherosclerosis [25]. Although several articles have indicated that the phenolic conversion coating on a Mg-alloy is non-toxic and anti-corrosive, chemical conversion may compromise stent integrity through the phenolic-Mg conversion process [26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Characterization of a Sandwich PLGA-Gallic Acid-PLGA Coating on Mg Alloy ZK60 for Bioresorbable Coronary Artery Stents

2020

View full text Add to dashboard Cite

Absorbable magnesium stents have become alternatives for treating restenosis owing to their better mechanical properties than those of bioabsorbable polymer stents. However, without modification, magnesium alloys cannot provide the proper degradation rate required to match the vascular reform speed. Gallic acid is a phenolic acid with attractive biological functions, including anti-inflammation, promotion of endothelial cell proliferation, and inhibition of smooth muscle cell growth. Thus, in the present work, a small-molecule eluting coating is designed using a sandwich-like configuration with a gallic acid layer enclosed between poly (d,l-lactide-co-glycolide) layers. This coating was deposited on ZK60 substrate, a magnesium alloy that is used to fabricate bioresorbable coronary artery stents. Electrochemical analysis showed that the corrosion rate of the specimen was ~2000 times lower than that of the bare counterpart. The released gallic acid molecules from sandwich coating inhibit oxidation by capturing free radicals, selectively promote the proliferation of endothelial cells, and inhibit smooth muscle cell growth. In a cell migration assay, sandwich coating delayed wound closure in smooth muscle cells. The sandwich coating not only improved the corrosion resistance but also promoted endothelialization, and it thus has great potential for the development of functional vascular stents that prevent late-stent restenosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Characterization of a Sandwich PLGA-Gallic Acid-PLGA Coating on Mg Alloy ZK60 for Bioresorbable Coronary Artery Stents

2020

View full text Add to dashboard Cite

show abstract

“…The amine group content on the coating surface was quantitatively analyzed by an acid orange II assay (AOII, Sigma-Aldrich), 28 and the phenolic hydroxyl group content on the coating surface was determined by a micro bicinchoninic acid (BCA) assay. 29,30 The water contact angle of the sample surface was measured using a Kruss GmbH DSA 100 Mk 2 goniometer at room temperature. Disulfide bonds provided by cystamine can be broken under increased oxidative stress in blood vessels, and pitavastatin calcium is released from the coating at a faster rate.…”

Section: Methodsmentioning

confidence: 99%

Application of a Reactive Oxygen Species-Responsive Drug-Eluting Coating for Surface Modification of Vascular Stents

Wang

Shang

Zhang

et al. 2021

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

Stent implantation is the primary method used to treat coronary heart disease. However, it is associated with complications such as restenosis and late thrombosis. Despite surface modification being an effective way to improve the biocompatibility of stents, the current research studies are not focused on changes in the vascular microenvironment at the implantation site. In the present study, an adaptive drug-loaded coating was constructed on the surface of vascular stent materials that can respond to oxidative stress at the site of vascular lesions. Two functional molecules, epigallocatechin gallate (EGCG) and cysteine hydrochloride, were employed to fabricate a coating on the surface of 316L stainless steel. In addition, the coating was used as a drug carrier to load pitavastatin calcium. EGCG has antioxidant activity, and pitavastatin calcium can inhibit smooth muscle cell proliferation. Therefore, EGCG and pitavastatin calcium provided a synergistic anti-inflammatory effect. Moreover, the coating was cross-linked using disulfide bonds, which accelerated the release of the drug in response to reactive oxygen species. A positive correlation was observed between the rate of drug release and the degree of oxidative stress. Collectively, this drug-loaded oxidative stress-responsive coating has been demonstrated to significantly inhibit inflammation, accelerate endothelialization, and reduce the risk of restenosis of vascular stents in vivo.

show abstract

“…in 1% vol acetic acid, 6 g/L BG 3.31–3.62 75 15–120 – – – – – – – [ 125 ] Gallic acid (GA)- hexamethylenediamine (HD) GA and HD were mixed (wt % 1:3, 1:1 and 2:1) – 37 360 – −1.59 −1.61 54.0 × 10 −5 8.0 × 10 −7 – An in-situ MgO/Mg(OH) 2 layer chelated beneath coating layers, obtained from 1:1 and 2:1 bath soln. [ 126 ] Catechol (CA)/polyethyleneimine (PEI) 2 mg/ml CA, 4 mg/ml PEI 8.5 22 720 5B −1.59 −1.37 Log (−4.19) Log (−7.34) 0.01 Heparinization treatment was given to coated samples by immersion in 4 mg/ml Heparin dissolved in water-soluble carbodiimide and a mixed solution of 1 mg/ml 1-ethyl-3-(3-(dimethylamino)propyl) carbodiimide hydrochloride (EDC) and 9.8 mg/ml 2- morpholino ethanesulfonic acid (MES). [ 127 ] Epigallocatechin gallate (EGCG)/polyethyleneimine (PEI) multilayer 1 mg/ml EGCG and 1 mg/ml PEI Soln in Tris-buffer.…”

Section: Coatings and Their Current Statusmentioning

confidence: 99%

Progress in bioactive surface coatings on biodegradable Mg alloys: A critical review towards clinical translation

Singh

Batra

Kumar

et al. 2023

Bioactive Materials

View full text Add to dashboard Cite

The anticorrosion mechanism of phenolic conversion coating applied on magnesium implants

Cited by 44 publications

References 27 publications

Characterization of a Sandwich PLGA-Gallic Acid-PLGA Coating on Mg Alloy ZK60 for Bioresorbable Coronary Artery Stents

Characterization of a Sandwich PLGA-Gallic Acid-PLGA Coating on Mg Alloy ZK60 for Bioresorbable Coronary Artery Stents

Application of a Reactive Oxygen Species-Responsive Drug-Eluting Coating for Surface Modification of Vascular Stents

Progress in bioactive surface coatings on biodegradable Mg alloys: A critical review towards clinical translation

Contact Info

Product

Resources

About