The Antidepressant-Like Actions of Furosemide, Bumetanide and Nifedipine in the Forced Swim Test in Mice

Oriaifo, S. E.; Omogbai, E. K. I.

doi:10.4314/wajpdr.v26i1.70060

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“…Data suggested that the need for sodium induces neural plasticity at central sites associated not only with body fluid balance, but also with motivation, reward and mood (Na et al, 2007). Recent evidence points out that the induction of salt appetite by furosemide may affect the physiological behaviour of rodents by activating the endogenous enkephalin/mµ-opioid receptor system (Grondin et al, 2011) and cross-sensitize with amphetamine (Clark and Bernstein, 2004); effects which may partially explain the increase in ingestive behaviour (Nathan et al, 2011) and antidepressant-like effects of furosemide (Oriaifo and Omogbai, 2010). In this study, we found that furosemide and bumetanide increased mice weight after 30 days by 7.33 and 5.3%, respectively, and this may reflect their influence on salt appetite and ingestive behaviour.…”

Section: Discussionmentioning

confidence: 99%

Comparative effects of imipramine, sertraline, nifedipine, furosemide and bumetanide on ingestive behaviour in mice

Oriaifo¹,

Omogbai²

2011

Afr. J. Biotechnol.

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The objective of the study was to evaluate the comparative effects of imipramine, sertraline, nifedipine, furosemide and bumetanide on ingestive behavior in rodents. Twelve groups (with six in each group) of male mice (25 to 35 g) were used in the experiments. They were housed in labelled plastic cages in the departmental laboratory and allowed access to food and water ad libitum. Six groups were treated respectively, with 10 mg/kg of furosemide, 5 mg/kg of sertraline, 5 mg/kg of nifedipine, 10 mg/kg of furosemide, 2.5 mg/kg of bumetanide and 0.25 ml of placebo, intraperitoneally daily for 30 days. Another six groups of mice were treated with the combination of furosemide (10 mg/kg) + sertraline (5 mg/kg); bumetanide (2.5 mg/kg) + sertraline (5 mg/kg); furosemide (10 mg/kg) + imipramine (10mg/kg); imipramin (10 mg/kg) + nifedipine (5 mg/kg); furosemide (10 mg/kg) + nifedipine (5 mg/kg) and placebo, respectively. The weights of the mice were recorded weekly for four weeks. Sertraline and imipramine decreased the weights of mice significantly at four weeks when compared to the controls (p < 0.05), while nifedipine and furosemide caused weight increases at four weeks, which is significantly different from the control (p < 0.05). Bumetanide did not cause significant weight increase when compared with controls (p > 0.05). In conclusion, the results suggest that sertraline and imipramine are anorexigenic in mice, while nifedipine and furosemide may be orexigenic.

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