2022
DOI: 10.1016/j.brainres.2022.147844
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The antidepressant-like effect of formononetin on chronic corticosterone-treated mice

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Cited by 20 publications
(12 citation statements)
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“…However, sevoflurane has a risk of causing perioperative neurocognitive disorders (PND). Xu et al (2022) showed that a 3% sevoflurane exposure induced cognitive impairment and the inhibition of adult hippocampal neurogenesis in the DG of aged (18-month-old) mice, but not adult (8-month-old) mice [48]. Consistently, downregulation of BDNF/TrkB and NT-3/TrkC were observed due to treatment with 3% sevoflurane.…”
Section: Neurotrophin Synaptic Function and Neurogenesismentioning
confidence: 79%
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“…However, sevoflurane has a risk of causing perioperative neurocognitive disorders (PND). Xu et al (2022) showed that a 3% sevoflurane exposure induced cognitive impairment and the inhibition of adult hippocampal neurogenesis in the DG of aged (18-month-old) mice, but not adult (8-month-old) mice [48]. Consistently, downregulation of BDNF/TrkB and NT-3/TrkC were observed due to treatment with 3% sevoflurane.…”
Section: Neurotrophin Synaptic Function and Neurogenesismentioning
confidence: 79%
“…Therefore, to achieve an upregulation of BDNF to improve behavior of both psychiatric and neurodegenerative disorders, targeting the BDNF/TrkB system with natural products has been prioritized [ 49 ]. A mice model of depression established by chronic treatment with corticosterone, a stress hormone, showed decreased hippocampal neurogenesis [ 50 ]. Interestingly, the application of formononetin (FMN), a type of isoflavone, improved the reduced neurogenesis caused by chronic corticosterone treatment [ 50 ].…”
Section: Neurotrophin Synaptic Function and Neurogenesismentioning
confidence: 99%
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“…The core active compounds mainly included flavonoids such as isosinensetin, formononetin, nobiletin and sterols such as stigmasterol, beta-sitosterol, and sitosterol. Formononetin is a type of isoflavone that upregulates the expression of the glucocorticoid receptor and brain-derived neurotrophic factor, protects neurons, and promotes neurogenesis in the hippocampus, thereby effectively reducing chronic corticosterone-induced depression-like behavior in mice ( 32 ). Nobiletin not only upregulates synaptic neurotransmission, improves memory impairment and monoamine function, but also produces antidepressant-like effects through the interaction of the serotonergic, noradrenergic and dopaminergic systems ( 33 ).…”
Section: Discussionmentioning
confidence: 99%
“…The results demonstrated that formononetin alleviated depression-like behaviors of model mice reflected by increasing the sucrose preference index and reducing immobility time in the forced swimming test. Mechanism study revealed that formononetin enhanced the expression level of the glucocorticoid receptor and BDNF, attenuated neuronal impairment and promoted neurogenesis in the hippocampus ( Zhang et al, 2022 ). The above researches laid a foundation for further studying the effects of formononetin on mental illness.…”
Section: Neuroprotective Effects Of Formononetinmentioning
confidence: 99%