The antidepressant-like effect of Hypericum caprifoliatum Cham &amp; Schlecht (Guttiferae) on forced swimming test results from an inhibition of neuronal monoamine uptake

Viana, Alice Fialho; Rego, Jean–Claude do; Poser, Gilsane von; Ferraz, Alexandre de Barros Falcão; Heckler, Ana Paula Machado; Costentin, Jean; Rates, Stela Maris Kuze

doi:10.1016/j.neuropharm.2005.06.002

Cited by 54 publications

(62 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…During the previous decade a number of studies focused on the antidepressant-like effects of extracts from several subspecies of St John's wort (Hypericum perfoliatum), which was traditionally used to treat wounds, eczema and disorders of the central nervous system (120) . Not only did these studies reveal replicable antidepressant effects in mice (121 -124) , analysis of monoamine uptake by rat synaptosomes showed that uptake of all three monoamines was inhibited by these extracts (121,124) . In addition to St John's wort, the presence of monoamine reuptake inhibitors was shown in the extracts of Siphocampylus verticillatus (a Brazilian medicinal plant) (125) , in Fructus Akebiae (a traditional Chinese cure for depressive disorders) (126) and Sideritis scardica (used as a tea, flavouring agent and universal remedy around the Mediterranean) (127) .…”

Section: Triple Monoamine Inhibitorsmentioning

confidence: 98%

Food-derived serotonergic modulators: effects on mood and cognition

Hulsken

Märtin

Mohajeri³

et al. 2013

Nutr. Res. Rev.

View full text Add to dashboard Cite

The most frequently described drugs in the treatment of mood disorders are selective serotonin reuptake and monoamine oxidase (MAO) inhibitors, enhancing serotonin levels in the brain. However, side-effects have been reported for these drugs. Because serotonin levels in the brain are dependent on the availability of the food-derived precursor tryptophan, foods such as chicken, soyabeans, cereals, tuna, nuts and bananas may serve as an alternative to improve mood and cognition. Here we discuss the effects of high-or low-tryptophancontaining food, as well as plant extracts with a modest monoamine reuptake and MAO-A inhibition functional profile, on mood and cognition in healthy and vulnerable human subjects and rodents. Together the studies suggest that there is an inverted U-shaped curve for plasma tryptophan levels, with low and too high tryptophan levels impairing cognition, and moderate to high tryptophan levels improving cognition. This relationship is found for both healthy and vulnerable subjects. Whereas this relationship may also exist for mood, the inverted U-shaped curve for plasma tryptophan levels and mood may be based on different tryptophan concentrations in healthy v. vulnerable individuals. Animal studies are emerging and allow further understanding of effects and the mode of action of food-derived serotonergic components on mood, cognition and mechanisms. Ultimately, insight into the concentrations of tryptophan and other serotonergic components in food having beneficial effects on mood and cognition in healthy, but particularly vulnerable, subjects may support well-being in our highly demanding society.

show abstract

Section: Triple Monoamine Inhibitorsmentioning

confidence: 98%

Food-derived serotonergic modulators: effects on mood and cognition

Hulsken

Märtin

Mohajeri³

et al. 2013

Nutr. Res. Rev.

View full text Add to dashboard Cite

show abstract

“…The FST was carried out according to Porsolt et al (1978) with minor modifications standardized and validated in our laboratory (Viana et al, 2005) as follows: mice were adapted to the laboratory conditions 1 h before being exposed to FST; the animals were individually forced to swim in a cylinder pool (10 cm diameter, 13 cm height, water at 22 AE 1 C) and the total duration of immobility during a 6 min test was scored (in seconds) by a human observer blinded to the treatments. Each mouse was considered immobile when it remained floating motionless or make only the movements necessary to keep its head above water.…”

Section: Forced Swimming Testmentioning

confidence: 99%

“…or 2% polysorbate 80 solution in saline (NaCl 0.9%) 30 min before the test. This dose was chosen based on previous studies of our group (Viana et al, 2005(Viana et al, , 2008. All treatments were administered at 10 ml/kg body weight.…”

Section: Forced Swimming Testmentioning

confidence: 99%

“…These phloroglucinol derivatives were proposed as chemotaxonomic markers for the southern Brazilian species (Nör et al, 2004). Among the species studied, Hypericum caprifoliatum Cham & Schlecht showed promising results in the forced swimming test (FST), which predicts antidepressant activity (Daudt et al, 2000;Viana et al, 2005Viana et al, , 2008. However, the molecular mechanisms by which these H. caprifoliatum extracts exert this antidepressant-like effect remains unclear.…”

Section: Introductionmentioning

confidence: 99%

“…Previous work by our group has shown that a cyclohexane extract of H. caprifoliatum and its enriched phloroglucinol fraction (HC1) inhibit the neuronal uptake of dopamine, noradrenaline and serotonin without direct interaction with their respective site on neuronal carriers, suggesting that H. caprifoliatum mechanism of action involves neurotransmitters transport in general (Viana et al, 2005). This hypothesis of mode of action has also been considered for hyperforin, a phloroglucinol derivative present in H. perforatum; Wonnemann & coworkers (2000) have proposed that this compound exerts its antidepressant action by mechanisms dependent on Na þ channels.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Study of antidepressant-like activity of an enriched phloroglucinol fraction obtained fromHypericum caprifoliatum

Centurião

Braga

Machado

et al. 2013

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Hypericum caprifoliatum Cham & Schlecht (Guttiferae) extracts have a potential antidepressant-like effect in rodents. However, the molecular mechanisms by which these extracts exert this effect remain unclear.Objective: This study evaluated the effect of HC1, a fraction obtained from H. caprifoliatum enriched in phloroglucinol derivatives, on the Naþ ATPase activity in mouse brain and verified the influence of veratrine on the effect of HC1 in the forced swimming test (FST). Materials and methods: Veratrine (0.06 mg/kg) and HC1 (360 mg/kg) were given alone or combined i.p. 60 and p.o. 30 min, respectively, before FST. The effect of single and repeated administration (once a day for 3 consecutive days) of HC1 (360 mg/kg) on Na þ , K þ ATPase activity was evaluated ex vivo in the cerebral cortex and hippocampus of mice subjected or not to FST. Results: HC1 reduced the immobility time (103.15 AE 18.67 s), when compared to the control group (183.6 AE 9.51 s). This effect was prevented by veratrine (151.75 AE 22.19 s). Mice repeatedly treated with HC1 presented a significant increase in Na þ , K þ ATPase activity, both in cerebral cortex (46 AE 2.41 nmol Pi/minÁmg protein) and hippocampus (49.83 AE 2.31 nmol Pi/minÁmg protein), in relation to the respective controls (30 AE 2.66 and 29.83 AE 2.31 nmol Pi/minÁmg protein respectively). Discussion and conclusion: The HC1 antidepressant-like effect on FST might be related to its capacity to inhibit Na þ influx. HC1 increases hippocampal and cortical Na þ , K þ ATPase activities possibly through long-term regulatory mechanisms.

show abstract

Antinociceptive Activity of Phloroglucinol Derivatives Isolated from Southern Brazilian Hypericum Species

Bridi

Stolz

Barros

et al. 2018

Chemistry & Biodiversity

View full text Add to dashboard Cite

The south Brazilian Hypericum species have revealed the presence of a series of biologically active phloroglucinol derivatives. In this study, a mixture of japonicine A and an isomer with an unreported structure, named japonicine E, was isolated from the roots of H. polyanthemum. Additionally, uliginosin A from H. myrianthum, isouliginosin B from H. polyanthemum, hyperbrasilol B and isohyperbrasilol B from H. caprifoliatum and cariphenone A from H. carinatum were also isolated. The structures were elucidated using 1D- and 2D-NMR experiments and by comparison with previously reported data. The compounds japonicines A/E, uliginosin A, isouliginosin B, hyperbrasilol B and cariphenone A exhibited antinociceptive activity in the mice hot-plate test and did not induce motor impairment in the rotarod apparatus.

show abstract

The antidepressant-like effect of Hypericum caprifoliatum Cham & Schlecht (Guttiferae) on forced swimming test results from an inhibition of neuronal monoamine uptake

Cited by 54 publications

References 46 publications

Food-derived serotonergic modulators: effects on mood and cognition

Food-derived serotonergic modulators: effects on mood and cognition

Study of antidepressant-like activity of an enriched phloroglucinol fraction obtained fromHypericum caprifoliatum

Antinociceptive Activity of Phloroglucinol Derivatives Isolated from Southern Brazilian Hypericum Species

Contact Info

Product

Resources

About