The antidepressant-like effect of trans-astaxanthin involves the serotonergic system

Jiang, Xi; Zhu, Keqi; Xu, Qiyou; Wang, Guokang; Zhang, Jia-Jia; Cao, Rongrong; Jiang, Ye; Yu, Xuefeng

doi:10.18632/oncotarget.16069

Cited by 23 publications

(19 citation statements)

References 40 publications

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“…Haematococcus pluvialis is a unicellular freshwater microalga that is rich in astaxanthin. The red ketocarotenoid astaxanthin (3,30-dihydroxy-β,β-carotene-4,40-dione) is the most powerful biological antioxidant and is highly demanded in health care and aquaculture, with the latest research showing that astaxanthin may play roles in anti-depression and preventing UVA-induced skin photoaging [ 1 , 2 , 3 , 4 ]. Astaxanthin is a 40-carbon isoprenoid and is synthesized from isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).…”

Section: Introductionmentioning

confidence: 99%

Transcriptome Analysis in Haematococcus pluvialis: Astaxanthin Induction by High Light with Acetate and Fe2+

Hou

Dong

et al. 2018

IJMS

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Haematococcus pluvialis is a commercial microalga, that produces abundant levels of astaxanthin under stress conditions. Acetate and Fe2+ are reported to be important for astaxanthin accumulation in H. pluvialis. In order to study the synergistic effects of high light stress and these two factors, we obtained transcriptomes for four groups: high light irradiation (HL), addition of 25 mM acetate under high light (HA), addition of 20 μM Fe2+ under high light (HF) and normal green growing cells (HG). Among the total clean reads of the four groups, 156,992 unigenes were found, of which 48.88% were annotated in at least one database (Nr, Nt, Pfam, KOG/COG, SwissProt, KEGG, GO). The statistics for DEGs (differentially expressed genes) showed that there were more than 10 thousand DEGs caused by high light and 1800–1900 DEGs caused by acetate or Fe2+. The results of DEG analysis by GO and KEGG enrichments showed that, under the high light condition, the expression of genes related to many pathways had changed, such as the pathway for carotenoid biosynthesis, fatty acid elongation, photosynthesis-antenna proteins, carbon fixation in photosynthetic organisms and so on. Addition of acetate under high light significantly promoted the expression of key genes related to the pathways for carotenoid biosynthesis and fatty acid elongation. Furthermore, acetate could obviously inhibit the expression of genes related to the pathway for photosynthesis-antenna proteins. For addition of Fe2+, the genes related to photosynthesis-antenna proteins were promoted significantly and there was no obvious change in the gene expressions related to carotenoid and fatty acid synthesis.

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Section: Introductionmentioning

confidence: 99%

Transcriptome Analysis in Haematococcus pluvialis: Astaxanthin Induction by High Light with Acetate and Fe2+

Hou

Dong

et al. 2018

IJMS

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“…Rutin isolated from Schinus molle L. appeared to exhibit antidepressant-like effect in mice, probably through enhanced availability of 5-HT and NE in the synaptic cleft [ 37 ]. Mice treated with taraxanthin showed antidepressant-like effect through the involvement of 5-HT system [ 38 ]. In short, most of the chemicals are exhibiting same mechanism of action as exhibited by generally used antidepressants that work either as selective 5-HT reuptake inhibitors, tricyclic antidepressants or MAO.…”

Section: Discussionmentioning

confidence: 99%

In Silico Prediction of the Anti-Depression Mechanism of a Herbal Formula (Tiansi Liquid) Containing Morinda officinalis and Cuscuta chinensis

Cheng

Murtaza

et al. 2017

Molecules

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Purpose: Depression is a sickening psychiatric condition that is prevalent worldwide. To manage depression, the underlying modes of antidepressant effect of herbals are important to be explored for the development of natural drugs. Tiansi Liquid is a traditional Chinese medicine (TCM) that is prescribed for the management of depression, however its underlying mechanism of action is still uncertain. The purpose of this study was to systematically investigate the pharmacological mode of action of a herbal formula used in TCM for the treatment of depression. Methods: Based on literature search, an ingredients-targets database was developed for Tiansi Liquid, followed by the identification of targets related to depression. The interaction between these targets was evaluated on the basis of protein-protein interaction network constructed by STITCH and gene ontology (GO) enrichment analysis using ClueGO plugin. Results: As a result of literature search, 57 components in Tiansi Liquid formula and 106 potential targets of these ingredients were retrieved. A careful screening of these targets led to the identification of 42 potential targets associated with depression. Ultimately, 327 GO terms were found by analysis of gene functional annotation clusters and abundance value of these targets. Most of these terms were found to be closely related to depression. A significant number of protein targets such as IL10, MAPK1, PTGS2, AKT1, APOE, PPARA, MAPK1, MIF, NOS3 and TNF-α were found to be involved in the functioning of Tiansi Liquid against depression. Conclusions: The findings elaborate that Tiansi Liquid can be utilized to manage depression, however, multiple molecular mechanisms of action could be proposed for this effect. The observed core mechanisms could be the sensory perception of pain, regulation of lipid transport and lipopolysaccharide-mediated signaling pathway.

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“…The forced swimming test (FST) was performed according to previous research (Jiang et al, 2017b). Each mouse was placed in the glass cylinder (height: 30 cm; diameter: 10 cm; containing 20 cm depth of water with a temperature of 24 ± 1 • C) for 6 min.…”

Section: Forced Swimming Testmentioning

confidence: 99%

“…The primer sequences of target RNAs are shown in Table 1. RNA amplification cycle was based on previous research (Jiang et al, 2017b).…”

Section: Quantitative Real-time Rt-pcrmentioning

confidence: 99%

Indoleamine-2,3-Dioxygenase Mediates Emotional Deficits by the Kynurenine/Tryptophan Pathway in the Ethanol Addiction/Withdrawal Mouse Model

Jiang¹,

Lin²,

Li³

et al. 2020

Front. Cell. Neurosci.

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Objective: Our study was designed to investigate whether the indoleamine-2,3dioxygenase (IDO)-mediated kynurenine/tryptophan (KYN/TRP) pathway participates in the development of emotional deficits from ethanol addiction/withdrawal mice. Methods:The expression of proinflammatory factors, including tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6), was tested by enzyme-linked immunosorbent assay (ELISA). The IDO levels in the hippocampus, cerebral cortex, and amygdala were measured by polymerase chain reaction (PCR) and western blot, and the neurotransmitters were tested by high performance liquid chromatography (HPLC). Emotional deficits of mice were evaluated by behavioral tests.Results: Expression levels of inflammatory factors (TNF-α, IL-1β, and IL-6) were increased in mice after 4 weeks of alcohol exposure. As for indoleamine 2,3dioxygenase (IDO) expression, only the subtype IDO1 was found to increase at both mRNA level and protein level in all the tested brain regions of ethanol addiction/withdrawal mice. In behavioral tests, mice exposed to alcohol showed gradually declined memory function accompanied by anxiety-like and depressive-like behaviors. Meanwhile, increased expression of KYN, decreased expression of 5-HT, and abnormal expression of 3-HK and KA were found in the hippocampus, cerebral cortex, and amygdala of ethanol addiction/withdrawal mice. Interestingly, the IDO1 inhibitor, 1-methyl-L-tryptophan (1-MT), reversed all above alterations induced by ethanol in mice. Conclusion:Our results suggested that the TRP/KYN pathway, medicated by IDO1, in the hippocampus, cerebral cortex, and amygdala, plays an important role in the development of emotional deficits caused by ethanol addiction and withdrawal.

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The antidepressant-like effect of trans-astaxanthin involves the serotonergic system

Cited by 23 publications

References 40 publications

Transcriptome Analysis in Haematococcus pluvialis: Astaxanthin Induction by High Light with Acetate and Fe2+

Transcriptome Analysis in Haematococcus pluvialis: Astaxanthin Induction by High Light with Acetate and Fe2+

In Silico Prediction of the Anti-Depression Mechanism of a Herbal Formula (Tiansi Liquid) Containing Morinda officinalis and Cuscuta chinensis

Indoleamine-2,3-Dioxygenase Mediates Emotional Deficits by the Kynurenine/Tryptophan Pathway in the Ethanol Addiction/Withdrawal Mouse Model

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