The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures

Sitges, Marı́a; Aldana, Blanca I.; Gómez, Carlos D.; Nekrassov, Vladimir

doi:10.1016/j.yebeh.2012.09.005

Cited by 21 publications

(21 citation statements)

References 23 publications

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“…In addition, Ohira et al (2013) found that fluoxetine stimulated the neurogenesis of GABAergic interneurons, which might have a suppressive effect on apoptosis induced by ischemia. Thus, the increase in GABAergic function in CA1-CA2 sectors and in dentate gyrus may contribute to the suppressive effect on the epileptic behavior and neurodegeneration observed after SSRIs administration in different animal models of epilepsy (Sitges et al, 2012). Nevertheless, although we detected no variations in NMDA, AMPA and kainate ionotropic glutamate receptors densities, and regarding the protective effects mediated by fluoxetine in this model, we cannot rule out direct (non 5-HT-mediated) actions of this SSRI on the glutamatergic central pathways.…”

Section: Discussionmentioning

confidence: 99%

Subacute administration of fluoxetine prevents short-term brain hypometabolism and reduces brain damage markers induced by the lithium-pilocarpine model of epilepsy in rats

Shiha

Cristóbal

Delgado

et al. 2015

Brain Research Bulletin

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Section: Discussionmentioning

confidence: 99%

Subacute administration of fluoxetine prevents short-term brain hypometabolism and reduces brain damage markers induced by the lithium-pilocarpine model of epilepsy in rats

Shiha

Cristóbal

Delgado

et al. 2015

Brain Research Bulletin

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“…Therefore, the possible in vivo action of sertraline on the cerebral expression of those inflammatory markers was tested in the hippocampus, which is a highly epileptogenic brain structure. Recently we found that generalized tonic-clonic seizures induced by the pro-convulsive agents pentylenetetrazole (PTZ), and 4-aminopyrydine (4-AP), increased the expression of IL-1β and TNF-α in the rat hippocampus (unpublished results), and that sertraline prevented seizures and the epileptiform EEG activity induced by those pro-convulsive agents [25]. Therefore, we also measured the effect of sertraline on the increase in those pro-inflammatory cytokines induced by seizures.…”

Section: Introductionmentioning

confidence: 95%

Sertraline Reduces IL-1β and TNF-α mRNA Expression and Overcomes Their Rise Induced by Seizures in the Rat Hippocampus

2014

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We recently discovered that the antidepressant sertraline is an effective inhibitor of hippocampus presynaptic Na+ channel permeability in vitro and of tonic-clonic seizures in animals in vivo. Several studies indicate that the pro-inflammatory cytokines in the central nervous system are increased in epilepsy and depression. On the other hand inhibition of Na+ channels has been shown to decrease pro-inflammatory cytokines in microglia. Therefore, the possibility that sertraline could overcome the rise in pro-inflammatory cytokine expression induced by seizures has been investigated. For this purpose, IL-1β and TNF-α mRNA expression was determined by RT-PCR in the hippocampus of rats administered once, or for seven consecutive days with sertraline at a low dose (0.75 mg/kg). The effect of sertraline at doses within the range of 0.75 to 25 mg/kg on the increase in IL-1β and TNF-α mRNA expression accompanying generalized tonic-clonic seizures, and increase in the pro-inflammatory cytokines expression induced by lipopolysaccharide was also investigated. We found that under basal conditions, a single 0.75 mg/kg sertraline dose decreased IL-1β mRNA expression, and also TNF-α expression after repeated doses. The increase in IL-1β and TNF-α expression induced by the convulsive agents and by the inoculation of lipopolysaccharide in the hippocampus was markedly reduced by sertraline also. Present results indicate that a reduction of brain inflammatory processes may contribute to the anti-seizure sertraline action, and that sertraline can be safely and successfully used at low doses to treat depression in epileptic patients.

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“…Sertraline at the single dose of 2.5 mg/kg or 0.75 mg/kg/day administered for one week, ameliorated 4-aminopyridine seizures in rats [91]. Sertraline at doses above 5 mg/kg reduced PTZ-induced seizures in rats [91]. In mice, the antidepressant (10 mg/kg p.o.…”

Section: Sertralinementioning

confidence: 99%

Pharmacokinetic/pharmacodynamic considerations for epilepsy – depression comorbidities

Banach

Popławska

Błaszczyk³

et al. 2016

Expert Opinion on Drug Metabolism & Toxicology

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The preclinical data may provide valuable clues on how to combine these two groups of drugs - antidepressant drugs neutral or potentiating the anticonvulsant action of antiepileptics are recommended in this regard. Avoidance of antidepressants clearly decreasing the convulsive threshold or decreasing the anticonvulsant efficacy of antiepileptic drugs (f.e. bupropion or mianserin) in patients with epilepsy is recommended.

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The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures

Cited by 21 publications

References 23 publications

Subacute administration of fluoxetine prevents short-term brain hypometabolism and reduces brain damage markers induced by the lithium-pilocarpine model of epilepsy in rats

Subacute administration of fluoxetine prevents short-term brain hypometabolism and reduces brain damage markers induced by the lithium-pilocarpine model of epilepsy in rats

Sertraline Reduces IL-1β and TNF-α mRNA Expression and Overcomes Their Rise Induced by Seizures in the Rat Hippocampus

Pharmacokinetic/pharmacodynamic considerations for epilepsy – depression comorbidities

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