The antidiabetic and antioxidant properties of some phenolic phytochemicals: A review study

Ahangarpour, Akram; Sayahi, Majed; Sayahi, Miaad

doi:10.1016/j.dsx.2018.11.051

Cited by 91 publications

(56 citation statements)

References 32 publications

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“…The testimony was in line with the statement of the previous researcher explained that the Malaka fruit has antidiabetic power [15,16]. This power is generated by the phenolic components [17,18]. The Malaka fruit is one of the most widely used fruits as traditional medication with many benefits [19][20][21].…”

Section: Introductionsupporting

confidence: 71%

Pharmaceutical hit of anti type 2 Diabetes mellitus on the phenolic extract of Malaka (Phyllanthus emblica L.) flesh

et al. 2019

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Background: Ethnobotany knowledge in a community has shaped local wisdom in utilizing plants to treat diseases, such as the use of Malaka (Phyllanthus emblica) flesh to treat type 2 diabetes. This study presented evidence that the phenolic extract of the Malaka flesh could reduce blood sugar levels in the diabetic induced rats. Methods: The phenolic extract of the P. emblica was administrated to the glucose-induced rats of the Wistar strain Rattus norvegicus for 14 days of treatment where the Metformin was used as a positive control. The data generated were analyzed by the two-way ANOVA Software related to the blood glucose level and by SAS Software related to the histopathological studies at a significant 95% confidence.Results: The phenolic extract with concentrations of 100 and 200 mg/kg body weight could reduce blood glucose levels in diabetic rats. The post hoc Dunnet test showed that the administration of the extract to the rats with a concentration of 100 mg/kg body weight demonstrated a very significant decrease in blood glucose levels and repaired damaged cells better than administering the extract at a concentration of 200 mg/kg weight body. Conclusion: The evidence indicated that the phenolic extract of the Malaka flesh can be utilized as anti type 2 Diabetes mellitus without damaging other organs.

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Section: Introductionsupporting

confidence: 71%

Pharmaceutical hit of anti type 2 Diabetes mellitus on the phenolic extract of Malaka (Phyllanthus emblica L.) flesh

et al. 2019

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“…At this point, the inhibition of cholinesterase could increase the level of acetylcholine in the synaptic cleft and these effects may help to improve cognitive dysfunctions in Alzheimer patients [ 38 ]. In another example, the blood glucose level in diabetes mellitus patients was controlled by the inhibition of amylase and glucosidase, which are the main clinically relevant carbohydrate-hydrolyzing enzymes [ 39 ]. From these perspectives, a panoply of compounds have been produced as enzyme inhibitors in the pharmaceutical area.…”

Section: Resultsmentioning

confidence: 99%

Chemical Characterization, Antioxidant, Enzyme Inhibition and Antimutagenic Properties of Eight Mushroom Species: A Comparative Study

Alkan

Uysal

Kaşik

et al. 2020

JoF

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This study aimed to determine the chemical composition and biologic activities of eight mushroom species (Amanita crocea, Hemileccinum depilatum, Cyclocybe cylindracea, Lactarius deliciosus, Hygrocybe acutoconica, Neoboletus erythropus, Russula aurea and Russula sanguinea). The antioxidant, enzyme inhibitory and mutagenic/antimutagenic activities were evaluated to provide data on the biologic activities. With respect to the chemical composition, LC–MS/MS technique was used to determine individual phenolic compounds present in the extracts. Antioxidant properties were investigated by different chemical methods including radical quenching (DPPH and ABTS), reducing power (CUPRAC and FRAP), phosphomolybdenum and metal chelating. In the enzyme inhibitory assays, cholinesterases, tyrosinase, amylase and glucosidase were used. Mutagenic and antimutagenic properties were evaluated by the Ames assay. In general, the best antioxidant abilities were observed from H. depilatum and N. erythropus, which also showed highest level of phenolics. The best cholinesterase inhibition ability was found from C. cylindracea (1.02 mg GALAE/g for AChE; 0.99 mg GALAE/g for BChE). Tyrosinase inhibition ability varied from 48.83 to 54.18 mg KAE/g. The extracts exhibited no mutagenic effects and showed significant antimutagenic potential. H. acutoconica, in particular depicted excellent antimutagenicity with a ratio of 97% for TA100 and with a rate of 96% for TA98 strain against mutagens in the presence of metabolic activation system. Results presented in this study tend to show that the mushroom species could be exploited as potential sources of therapeutic bioactive agents, geared towards the management of oxidative stress, global health problems and cancer.

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“…In the meantime, the link between anti-diabetic and antioxidant activities of drugs has been confirmed through in vivo experiments and theoretical calculations using protocatechuic acid and glibenclamide as models [54]. The naturally occurring phenolic derivatives such as hydroxytyrosol, resveratrol and curcumin, for example, have been found to exhibit antidiabetic and antioxidant activities in different ways besides other effects like anti-inflammatory and anti-carcinogenic properties [55]. These literature precedents encouraged us to evaluate compounds 2a-h for potential antioxidant properties using the DPPH free-radical scavenging method.…”

Section: Inhibition Of α-Glucosidase Ptp1b and β-Secretase And Antiomentioning

confidence: 90%

Synthesis, In Vitro Evaluation and Molecular Docking of the 5-Acetyl-2-aryl-6-hydroxybenzo[b]furans against Multiple Targets Linked to Type 2 Diabetes

et al. 2020

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The 5-acetyl-2-aryl-6-hydroxybenzo[b]furans 2a-h have been evaluated through in vitro enzymatic assay against targets which are linked to type 2 diabetes (T2D), namely, α-glucosidase, protein tyrosine phosphatase 1B (PTP1B) and β-secretase. These compounds have also been evaluated for antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging method. The most active compounds against α-glucosidase and/or PTP1B, namely, 4-fluorophenyl 2c, 4-methoxyphenyl 2g and 3,5-dimethoxyphenyl substituted 2h derivatives were also evaluated for potential anti-inflammatory properties against cyclooxygenase-2 activity. The Lineweaver-Burk and Dixon plots were used to determine the type of inhibition on compounds 2c and 2h against α-glucosidase and PTP1B receptors. The interactions were investigated in modelled complexes against α-glucosidase and PTP1B via molecular docking.

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The antidiabetic and antioxidant properties of some phenolic phytochemicals: A review study

Cited by 91 publications

References 32 publications

Pharmaceutical hit of anti type 2 Diabetes mellitus on the phenolic extract of Malaka (Phyllanthus emblica L.) flesh

Pharmaceutical hit of anti type 2 Diabetes mellitus on the phenolic extract of Malaka (Phyllanthus emblica L.) flesh

Chemical Characterization, Antioxidant, Enzyme Inhibition and Antimutagenic Properties of Eight Mushroom Species: A Comparative Study

Synthesis, In Vitro Evaluation and Molecular Docking of the 5-Acetyl-2-aryl-6-hydroxybenzo[b]furans against Multiple Targets Linked to Type 2 Diabetes

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