The Antiemetic Effect of Droperidol Following Outpatient Strabismus Surgery in Children

Abramowitz, Michael D.; Oh, Tae Hee; Epstein, Bernard S.; Ruttiman, Urs; Friendly, David S.

doi:10.1097/00132586-198408000-00061

Cited by 24 publications

(37 citation statements)

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“…The 22-30% incidence of emetic symptoms in this study was low compared with the 41435% reported by other workers (Abramowitz et al 1983;Hardy et al 1986;Broadman et al 1990;Larsson & Johmarker 1990;Horimoto et al 1991). In this study, narcotics the postoperative period.…”

Section: Discussioncontrasting

confidence: 59%

Anticholinergic prophylaxis does not prevent emesis following strabismus surgery in children

Chisakuta

Mirakhur

1995

Pediatric Anesthesia

117

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One hundred and twenty-one children were studied in this prospective, randomized double-blind, placebo-controlled comparison of the effectiveness of anticholinergic prophylaxis for the prevention of emetic symptoms following strabismus surgery. The children were allocated to three groups, to receive placebo (n = 40), glycopyrrolate (n = 40) or atropine (n = 41). The incidence of intraoperative oculocardiac reflex (OCR) and of postoperative emetic symptoms for 24 h was recorded. The incidence of OCR was 55% in the placebo group compared with 5% and 2% in the glycopyrrolate and atropine groups respectively (P < 0.05). Thirty percent (12/40) of patients in the placebo group, 25% (10/40) in the glycopyrrolate group, and 22% (9/41) in the atropine group experienced nausea and/or vomiting (difference not significant). It is concluded that prophylactic administration of anticholinergic agents during strabismus surgery in children despite being effective against the occurrence of the oculocardiac reflex, does not reduce the incidence of emetic symptoms.

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Section: Discussioncontrasting

confidence: 59%

Anticholinergic prophylaxis does not prevent emesis following strabismus surgery in children

Chisakuta

Mirakhur

1995

Pediatric Anesthesia

117

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“…Fung [10] beschreibt Patientenzufriedenheit als Grad der Kongruenz zwischen Erwartungen des Patienten und deren Erfüllung, wobei postoperative Schmerzen sowie Übelkeit und Erbrechen besonders wichtige Variablen sind [5,6,11,13]. Obwohl schlecht belegt wird zwischen Schmerz und PONV schon seit langem ein Zusammenhang vermutet [12].…”

Section: Diskussionunclassified

Blockade nozizeptiver oculärer Afferenzen durch Retrobulbäranästhesie vermindert nicht Übelkeit und Erbrechen nach Propofol-Remifentanil-Anästhesie

2003

Anasthesiol Intensivmed Notfal

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Although prophylactic blockade of nozizeptive afferents by retrobulbar anesthesia decreased ocular pain and postoperative complaints, it failed to decrease the incidence of PONV. Thus, PONV after ocular surgery under propofol-remifentanil anaesthesia is not attenuated by preoperative blockade of noziceptive afferents. In patients undergoing total intravenous anaesthesia with propofol-remifentanil, droperidol prevented PONV more effectively than the used serotonin receptor antagonists.

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“…This age group usually has a high incidence of PONY. In 1983, Abramowitz [13] and later in 1986, Lerman et aU15] found that droperidol in larger doses of 75 Ilg/kg was an effective pretreatment for nausea and vomiting in children following strabismus surgery. Eustis et al [57] found that droperidol doses of 25 to 50 Ilg/kg were not as effective as those of75Ilg/kg.…”

Section: Clinical Studiesmentioning

confidence: 99%

“…The incidence of PONY following day surgery for fe- male adults undergoing minor gynaecological operations receiving placebo can be as high as 58 to 83%, [5][6][7][8] and is about 2 to 3 times that in adult males.l 9 -12 ] The incidence ofPONV in children undergoing strabismus surgery can be up to 85%. [13][14][15] PONY is also a leading cause of prolonged PACU stay or unplanned hospital admission following ambulatory surgical procedures. [16,17] In mild cases of PONY, the complications may include unpleasant feelings of anxiety.…”

mentioning

confidence: 99%

Risks and Benefits of Drugs Used in the Management of Postoperative Nausea and Vomiting

Sung

1996

Drug Safety

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Postoperative nausea and vomiting (PONV) is an age-old problem; more so since the blooming of ambulatory or day surgery centres within the last 2 decades. The aetiology of PONV is multifactorial. The incidence of PONV is usually higher in women and children than in men. PONV not only causes patient discomfort, anxiety in mild cases, and serious complications in severe cases, it also decreases cost efficiency. The benefits and risks of old and new antiemetic drugs used worldwide to treat PONV are discussed in this article, including the newly developed serotonin 5-hydroxytryptamine 3 (5HT3) antagonists. All the medications currently used to treat PONV have both advantages and disadvantages. If used indiscriminately to treat patients who have no problems with PONV, the risks of adverse effects often outweigh the benefits. The patient's history and the nature of the surgery are good indicators for defining those at risk from PONV; for patients at risk preventive treatment is essential. However, it is almost impossible to pick one agent or one combination as the therapy of choice using the present available data. A patient history of a favourable response to a previously used antiemetic would make that drug the agent of choice. So far, the newcomers, the 5HT3 antagonists, have fewer reported adverse effects.

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The Antiemetic Effect of Droperidol Following Outpatient Strabismus Surgery in Children

Cited by 24 publications

References 0 publications

Anticholinergic prophylaxis does not prevent emesis following strabismus surgery in children

Anticholinergic prophylaxis does not prevent emesis following strabismus surgery in children

Blockade nozizeptiver oculärer Afferenzen durch Retrobulbäranästhesie vermindert nicht Übelkeit und Erbrechen nach Propofol-Remifentanil-Anästhesie

Risks and Benefits of Drugs Used in the Management of Postoperative Nausea and Vomiting

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