The Antiemetic Effect of Droperidol Following Outpatient Strabismus Surgery in Children

Abramowitz, Michael D.; Oh, Tae Hee; Epstein, Bernard S.; Ruttimann, Urs E.; Friendly, David S.

doi:10.1097/00000542-198312000-00021

Cited by 131 publications

(21 citation statements)

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“…The reported incidence of PONV after pediatric strabismus surgery was 60% [21] and 85% [22] in previously published studies when no prophylactic antiemetic is given. The primary outcome of the current study was to determine the doseresponse relationship of single intravenous doses of palonosetron for the prevention of PONV in children undergoing strabismus surgery.…”

Section: Discussionmentioning

confidence: 99%

Different Doses of Palonosetron for the Prevention of Postoperative Nausea and Vomiting in Children Undergoing Strabismus Surgery

et al. 2011

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Background: Postoperative vomiting is a common complication after strabismus surgery in children. The serotonin 5-HT 3 receptor antagonists have proven to be a particularly valuable addition to the armamentarium against postoperative nausea and vomiting (PONV). Palonosetron is a secondgeneration 5-HT 3 receptor antagonist that has recently been approved for prophylaxis against PONV. Objective: The aim of this study was to evaluate the efficacy of different doses of palonosetron for the prevention of PONV in children undergoing strabismus surgery. Patients and Method: A total of 150 children who were classified with an American Society of Anesthesiologists physical status of I, were aged between 2 and 12 years, and were undergoing strabismus surgery under general anesthesia were enrolled in the study. A random numbers table was used to assign each child to receive palonosetron 0.5, 1.0, or 1.5 mg/kg (n = 50 in each group). All episodes of PONV at the intervals of 0-2, 2-6, 6-24, and 24-48 hours were evaluated using a numeric scoring system for PONV. A p-value of <0.05 was considered statistically significant. Results: The percentage of children with PONV during 0-48 hours after anesthesia was 24% with palonosetron 0.5 or 1.0 mg/kg, and 20% with palonosetron 1.5 mg/kg. There was no statistically significant difference between the study groups with respect to the number of children with PONV scores of 1, 2, or 3 during 0-48 hours after anesthesia. There was no statistically significant difference between the study groups with respect to the number of children with postoperative vomiting during all time periods after anesthesia. The percentage of children aged >6 years with postoperative nausea during 0-48 hours after anesthesia was 8.6%, 18.2%, and 15.4% with palonosetron 0.5, 1.0, or 1.5 mg/kg, respectively, but there was no statistically significant difference between the study groups.

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Section: Discussionmentioning

confidence: 99%

Different Doses of Palonosetron for the Prevention of Postoperative Nausea and Vomiting in Children Undergoing Strabismus Surgery

et al. 2011

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“…The incidence of postoperative emesis after strabismus surgery in children who have not received prophylactic anti-emetic therapy has been reported to range from 41 to 85% [4,9,10]. The variation in the incidence of vomiting cited in the literature can be attributed to the influence of many factors including the use of opioid analgesia [11], administration of anti-emetics [4], anaesthetic technique [12] and the use of propofol [11].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of ondansetron and metoclopramide for preventing postoperative emesis following strabismus surgery in children

Shende

Mandal

1997

Anaesthesia

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SummaryA double-blind, randomised, placebo-controlled trial was conducted to compare the efficacy of metoclopramide with the 5-HT 3 antagonist, ondansetron, for the prevention of postoperative emesis in children undergoing elective strabismus surgery. None of the children received any premedication and a similar anaesthetic technique was used for all. Ondansetron 0.15 mg.kg ÿ 1 , metoclopramide 0.25 mg.kg ÿ 1 or saline placebo were administered following intravenous catheter placement. Episodes of emesis were recorded for the first 24 h for the intervals of 0-2, 2-6 and 6-24 h. The incidence of emesis in the first 24 h was observed to be 71.7% in the placebo group, 34.4% in the ondansetron group (p < 0.001) and 61.4% in the metoclopramide group (p = NS). The severity of vomiting was less in the ondansetron group as compared with metoclopramide (p < 0.01) and placebo (p < 0.001). Recovery room scores were comparable in all the groups. No serious side-effects were observed in the ondansetron group. We conclude that prophylactic ondansetron is effective and superior to metoclopramide in the prevention of postoperative emesis in children following elective strabismus surgery.

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“…Strabismusoperationen, die vor allem bei Kindern durchgeführt werden, die Inzidenz von PONV mit bis zu 80% extrem hoch [2]. Auch nach intraokularen und anderen extraokularen Eingriffen kommen Übelkeit und Erbrechen mit einer Inzidenz von bis zu 40% häufiger vor als bei vielen anderen Operationen [127].…”

Section: Patienten Nach Augenoperationen Sind Besonders Oft Davon Betunclassified

Dolasetron, Droperidol und die Kombination beider Substanzen zur Prophylaxe von Übelkeit und Erbrechen nach extrakapsulären Kataraktextraktionen in Allgemeinanästhesie

Eberhart

Lindenthal²,

Seeling³

et al. 1999

Anästhesiol Intensivmed Notfallmed Schmerzther

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The Antiemetic Effect of Droperidol Following Outpatient Strabismus Surgery in Children

Cited by 131 publications

References 0 publications

Different Doses of Palonosetron for the Prevention of Postoperative Nausea and Vomiting in Children Undergoing Strabismus Surgery

Different Doses of Palonosetron for the Prevention of Postoperative Nausea and Vomiting in Children Undergoing Strabismus Surgery

Efficacy of ondansetron and metoclopramide for preventing postoperative emesis following strabismus surgery in children

Dolasetron, Droperidol und die Kombination beider Substanzen zur Prophylaxe von Übelkeit und Erbrechen nach extrakapsulären Kataraktextraktionen in Allgemeinanästhesie

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