The antifungal action of three South African honeys on <i>Candida albicans</i>

Theunissen, F; Grobler, S.R.; Gedalia, I.

doi:10.1051/apido:2001137

Cited by 47 publications

(34 citation statements)

References 18 publications

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“…This was observed in all microorganisms tested (Table 2). In the same way, previous reports demonstrated that increased honey concentrations resulted in reduced growth of C. albicans, namely 29.4% inhibition on the growth was verified in the presence of wasbessie honey at concentrations of 25% (Theunissen et al 2001). The minimum inhibitory concentration of honeys against isolates of Candida species (C. albicans C. glabrata and C. dubliniensis) would be achievable in a clinical setting (Irish et al 2006); C. dublinensis was more susceptible to the osmotic effect of all honeys, and to the antifungal effects of Jarrah honey.…”

Section: Introductionsupporting

confidence: 74%

“…To date, very few attempts have been made to assess the antifungical properties of honey (Theunissen et al 2001;Irish et al 2006;Küçük et al 2007;Boukraa et al 2008;Koc et al 2008), especially as compared to the large volume of published literature which has established that honey has significant antibacterial activity. The incidence of fungal infections is increasing in community and hospital environments (Fridkin 2005) and no other mycotic patho-gen produces as great a spectrum of opportunistic diseases in humans and animals as Candida does (Pappas et al 2003;Tortorano et al 2006).…”

Section: Introductionmentioning

confidence: 99%

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Antifungal effect of lavender honey against Candida albicans, Candida krusei and Cryptococcus neoformans

2011

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Monofloral lavender honey samples (n=30), were analyzed to test antifungal effect against Candida albicans, Candida krusei, and Cryptococcus neoformans. The specific growth rates (μ) showed that all the yeast growths were reduced in the presence of honey. The honey concentration (% w/v) that inhibited 10% of the yeasts growth (X min ) ranged from 31.0% (C. albicans), 16.8% (C. krusei) and 23.0% (C. neoformans). A synthetic honey solution was also tested to determine antifungal activity attributable to sugars. The presence of synthetic honey in the C. krusei culture medium at concentrations above 58.0% (w/v) was established as X min , while C. albicans and C. neoformans were more resistant, since X min values were not reached over the ranged tested (10-60%, w/v). What the data suggests is that the component in the lavender honey responsible for the observed antifungal in vitro properties is not sugar based. Honey might be tapped as a natural resource to look for new medicines for the treatment of mycotic infections. This could be very useful, onsidering the increasing resistance of antifungals. It should be noticed that this is the first study concerning the effect of lavender honey on the growth of pathogenic yeasts.

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Section: Introductionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Antifungal effect of lavender honey against Candida albicans, Candida krusei and Cryptococcus neoformans

2011

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“…When analyzing and studying the therapeutic properties of honeys, modern science has made it possible to specify their medical significance for healing wounds and burns (Molan, 2001), oncology care (Bardy et al, 2008), as well as its antioxidant and antimicrobial factors (Gomes et al, 2010;Akbulut et al, 2009;Theunissen et al, 2001). It is clear that honeys to be used for therapeutic purposes should be harvested in areas with no contamination sources (Feás and Estevinho, 2011).…”

Section: Introductionmentioning

confidence: 99%

Organic honey from Trás-Os-Montes region (Portugal): Chemical, palynological, microbiological and bioactive compounds characterization

Estevinho

Feás

Seijas

et al. 2012

Food and Chemical Toxicology

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a b s t r a c tAt the present time, the quality, integrity, sanitation and nutritional value of honeys receive attention on an international level due to the increasing content of chemicals in the aforementioned matrix. This work was conducted to evaluate the quality of 75 organic honey samples from the Trás-Os-Montes region (Portugal). Mean values obtained for physico-chemical parameters were: pH 3.7; 15.6% moisture; 0.26 mS/cm electrical conductivity; 0.25% ash; 1.1 mg/kg HMF; 15.3 Gothe diastase activity; 40.3 meq/kg free acidity; 67.8% invert sugars and 2.7% apparent sucrose. All honey samples can be classified as monofloral Erica sp., as showed by pollen features. The amounts of phenols and flavonoids in the samples were also determined. In respect to sanitary quality (fecal coliforms) and safety (sulfite-reducing clostridia and Salmonella), all organic honey samples were negative. Furthermore, yeast and molds were detected in low counts, with mean values obtained of 5.5 cfu/g and the value of total aerobic mesophiles obtained from honeys was established in 1.3 Â 10 2 cfu/g ± 7.5 Â 10 1 cfu/g. The levels of flavonoids had a stronger impact on both mesophiles (p = 0.0004) and molds (p = 0.0138) than the sucrose concentration (p = 0.001 and 0.0278; respectively). The results reported in this study should be introduced in the organic honey label, and may help beekeepers, the industry, researchers and consumers better understand honey properties.

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“…In the face of the persistent honey-induced hyperglycemia, the body weight of these patients decreased without diet restrictions, and they did not develop DKA or HHS. The antioxidant [12][13][14], the anti-microbial [15][16][17][18][19], the immune modulator [20] and the anti-inflammatory properties [21][22][23][24] of honey helps also justification for this research.…”

Section: Justification Of the Researchmentioning

confidence: 99%

“…Moreover, honey is not expensive. Honey as an emerging novel anti-diabetic agent has been recently recognized in several studies [5][6][7][8][9][10][11], suggesting that honey, through its anti-oxidant [12][13][14], anti-microbial [15][16][17][18][19], immune modulator [20] and anti-In November, 2013, author reported in the journal of clinical trials a case of Coronary Heart Disease (CHD), hypertension and type 2 DM, who stopped his medicines and used honey as an alternative therapy for almost 11 years [25]. In spite of persistent hyperglycemia and dyslipidemia, unexpectedly, his blood pressure was controlled, his CHD improved or at least stabilized.…”

Section: Introductionmentioning

confidence: 99%

Honey as a Sole Treatment of Type 2 Diabetes Mellitus

Abdulrhman¹

2016

Endocrinol Metab Syndr

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Objectives: The complications from type 2 diabetes mellitus (DM) still occur despite the ongoing efforts to prevent, or decrease it. This clinical trial aimed to evaluate the effects of honey, as an alternative, non-expensive natural substance in twenty adult patient volunteers suffering from type 2 DM and its associated metabolic derangements. Methods:The patients volunteered to stop the medicines and use honey as a sole treatment of their illnesses. There was no specific dietary restriction except for food preservatives and additives, beverages and sweets.Results: Honey consumption resulted in more hyperglycemia in these patients, but without diabetic ketoacidosis (DKA) or hyperglycemic hyperosmolar state (HHS). Longer-term honey consumption resulted also in weight reduction in all the patients, and control of the blood pressure in the patients, who had hypertension before the honey intervention. The median duration of the honey intervention, without anti-diabetic medicines was 1.09 years, with a range from 0.42 to 13.5 years. Ten of the 20 patients continued the honey intervention for more than 1 year, whereas the other 10 continued the intervention for one year or less. The only cause of the discontinuation of the honey intervention was persistent hyperglycemia. Despite persistent hyperglycemia in all the patients, and persistence of the dyslipidemia in the patients, who had dyslipidemia before the intervention, the macro-vascular complications, particularly the coronary heart disease (CHD), did not develop in any of them. On the contrary, the cardiovascular status improved in the patients, who had CHD before the intervention. However, micro-vascular complications developed in two patient volunteers, who continued the honey intervention, without medicines, for more than 8 years. Conclusion:The author imposed on announcing these results, which might be of help for the patients with diabetes mellitus.

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The antifungal action of three South African honeys on Candida albicans

Cited by 47 publications

References 18 publications

Antifungal effect of lavender honey against Candida albicans, Candida krusei and Cryptococcus neoformans

Antifungal effect of lavender honey against Candida albicans, Candida krusei and Cryptococcus neoformans

Organic honey from Trás-Os-Montes region (Portugal): Chemical, palynological, microbiological and bioactive compounds characterization

Honey as a Sole Treatment of Type 2 Diabetes Mellitus

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