The antifungal activity of cinnamaldehyde in vapor phase against Aspergillus niger isolated from spoiled paddy

Niu, Ajuan; Wu, Hongying; Ma, Feifei; Tan, Song Wei Benjamin; Wang, Guangyu; Qiu, Wei

doi:10.1016/j.lwt.2022.113181

Cited by 36 publications

(19 citation statements)

References 42 publications

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“…The decreased MMP further proved that mitochondria were a physiological target for SBC and NT to inhibit fungal growth. The results of this study were similar to the findings in Fusarium solani cells with synergistic treatment by thymol and salicylic acid ( Kong et al, 2021 ) and in A. niger after treatment with cinnamaldehyde in the vapor phase ( Niu et al, 2022 ). Similarly, Tan et al (2022) found sodium dehydroacetate interference with cell membrane metabolism and energy metabolism in the antifungal mechanism against P. digitatum .…”

Section: Discussionsupporting

confidence: 88%

“…A similar result was found by He et al (2019) , who pointed out that NT may affect membrane function by reducing ergosterol synthesis because ergosterols are important in maintaining cell function in the transport of cellular material and physiology. Reductions in total lipid and ergosterol levels usually reflect irreversible damage to cell membranes ( Niu et al, 2022 ). However, Te Welscher et al (2010) suggested that the antifungal mechanism of NT was that it could combine with ergosterol on the cell membrane of fungi to change the permeability of the cell membrane.…”

Section: Discussionmentioning

confidence: 99%

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Isolation, identification, biological characteristics, and antifungal efficacy of sodium bicarbonate combined with natamycin on Aspergillus niger from Shengzhou nane (Prunus salicina var. taoxingli) fruit

Guo

Zeng²,

Guo³

et al. 2023

Front. Microbiol.

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The fungi causing fruit rot were isolated from symptomatic Shengzhou nane (Prunus salicina var. taoxingli) fruit and were identified as Aspergillus niger by biological characteristics and molecular analysis of the internal transcribed spacer region (rDNA-ITS) and translation elongation factor-1α (TEF-1α) sequences. Optimal growth conditions for A. niger were 30°C, pH 5.0–6.0, and fructose and peptone as carbon and nitrogen sources. The effects of sodium bicarbonate (SBC), natamycin (NT), and combined treatments on A. niger inhibition were investigated. Treatment with 4.0 g/L sodium bicarbonate (SBC) + 5.0 mg/L natamycin (NT) inhibited mycelial growth and spore germination as completely as 12.0 mg/L SBC or 25.0 mg/L NT. SBC and NT treatments disrupted the structural integrity of cell and mitochondria membranes and decreased enzyme activities involved in the tricarboxylic acid (TCA) cycle, mitochondrial membrane potential (MMP), ATP production in mitochondria, and ergosterol content in the plasma membrane, thus leading to the inhibition of A. niger growth. Moreover, experimental results in vivo showed that the rot lesion diameter and decay rate of Shengzhou nane fruit treated with SBC and NT were significantly reduced compared with the control. The results suggest that the combination treatment of SBC and NT could be an alternative to synthetic fungicides for controlling postharvest Shengzhou nane decay caused by A. niger.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Isolation, identification, biological characteristics, and antifungal efficacy of sodium bicarbonate combined with natamycin on Aspergillus niger from Shengzhou nane (Prunus salicina var. taoxingli) fruit

Guo

Zeng²,

Guo³

et al. 2023

Front. Microbiol.

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“…Khan et al (2015) reported that carvacrol at a concentration of 2-10 mg/L caused a 3.47-5.13-fold increase in lipid peroxidation in Candida albicans cells and further membrane deterioration. Niu et al (2022) suggested that the enhanced MDA biosynthesis of A. niger cells treated by cinnamaldehyde vapor may be associated with the destroyed cell membrane function and integrity. The increased level of superoxide anion may be the result of accelerated oxygen uptake by the damaged organism.…”

Section: Methylglyoxal Content and Antiaflatoxigenic Effectmentioning

confidence: 99%

“…However, the antifungal and aflatoxigenic mechanisms published so far have been mostly related to the phenol compounds of oregano oil directly added into the medium, such as carvacrol and thymol (Chavan & Tupe, 2014; Hu et al, 2018; Khan et al, 2015). In addition, there are only discussions related to the mechanism of EO vapor against non‐toxicogenic fungi such as Penicillium expansum (da Rocha Neto et al, 2019) and Aspergillus niger (Niu et al, 2022). To the best of our knowledge, there has been no systematic study of the antifungal and anti‐aflatoxigenic mechanisms of OEO vapor, and the changes within mycelial cells treated by OEO vapor are still unclear.…”

Section: Introductionmentioning

confidence: 99%

Study on the antifungal effect and mechanism of oregano essential oil fumigation against Aspergillus flavus

Tang

Fan

2022

Food Processing Preservation

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The fumigation treatment with oregano essential oil (OEO) was applied to inactivate Aspergillus flavus (A. flavus) and its mechanism was studied. Results indicated that the minimal fungicidal concentration (MFC) of OEO vapor was lower than OEO dissolved in liquid medium. Indeed, OEO vapor at MFC resulted in the abnormal branching of A. flavus mycelium. Further, the fumigation time at MFC required for fungicidal effect was reduced from 7 days to 8 h by enhancing the fumigation temperature from 28 to 45°C. Meanwhile, the mechanism of action might be the oxidative stress in response to OEO vapor within the cells of A. flavus mycelium. Results suggested increased lipid peroxidation and O2− production as well as SOD/CAT activity, eventually leading to decreased mitochondrial activity and ATP production. Additionally, OEO vapor inhibited metabolic activities related to the synthesis of protein and methylglyoxal as well as aflatoxin production. Novelty impact statement OEO exhibited a higher fungicidal effect on A. flavus mycelium compared to its spores. OEO fumigation exhibited an inhibitory effect on the metabolic synthesis of A. flavus. OEO fumigation induced oxidative stress and decreased mitochondrial activity.

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“…The main aromatic compound in cinnamon essential oil (CEO) is cinnamaldehyde, with a content of 80%–94.8%, and which can be directly extracted from cinnamon ( Liu et al, 2021 ). This renewable biomass of cinnamaldehyde has many useful functions, such as anti- Leishmania activity ( Brustolin et al, 2022 ), antifungal activity ( Niu et al, 2022 ), antibacterial activity ( Wang et al, 2021 ), antimicrobial activity ( Thirapanmethee et al, 2021 ), and improvement of wood decay resistance ( Fang et al, 2021 ). Furthermore, it is easy to synthesize derivatives with biological activity using cinnamaldehyde, such as cinnamaldehyde-based aspirin derivatives ( Lu et al, 2018 ) and chitosan-cinnamaldehyde cross-linked nanoparticles ( Gadkari et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, determination, and bio-application in cellular and biomass-bamboo imaging of natural cinnamaldehyde derivatives

Yang

Guo

Yang

et al. 2022

Front. Bioeng. Biotechnol.

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Cinnamon essential oil (CEO) is the main ingredient in the renewable biomass of cinnamon, which contains natural cinnamaldehyde. To valorize the value of cinnamaldehyde, two simple and useful compounds (1 and 2) from CEO were synthesized using a Schiff-base reaction and characterized by infrared spectra (IR), nuclear magnetic resonance (NMR), and high-resolution mass spectrometry (HRMS). Compound 1 was used to confirm the presence of Fe3+ and ClO− in solution, as well as compound 2. Using fluorescence enhancement phenomena, it offered practicable linear relationship of 1’s fluorescence intensity and Fe3+ concentrations: (0–8.0 × 10−5 mol/L), y = 36.232x + 45.054, R2 = 0.9947, with a limit of detection (LOD) of 0.323 μM, as well as compound 2. With increasing fluorescence, F404/F426 of 1 and the ClO− concentration (0–1.0 × 10−4 mol/L) also had a linear relationship: y = 0.0392x + 0.5545, R2 = 0.9931, LOD = 0.165 μM. However, the fluorescence intensity of 2 (596 nm) was quenched by a reduced concentration of ClO−, resulting in a linear. In addition, compounds 1 and 2 were used to image human astrocytoma MG (U-251), brain neuroblastoma (LN-229) cells, and bamboo tissue by adding Fe3+ or ClO−, with clear intracellular fluorescence. Thus, the two compounds based on CEO could be used to dye cells and bamboo tissues by fluorescence technology.

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The antifungal activity of cinnamaldehyde in vapor phase against Aspergillus niger isolated from spoiled paddy

Cited by 36 publications

References 42 publications

Isolation, identification, biological characteristics, and antifungal efficacy of sodium bicarbonate combined with natamycin on Aspergillus niger from Shengzhou nane (Prunus salicina var. taoxingli) fruit

Isolation, identification, biological characteristics, and antifungal efficacy of sodium bicarbonate combined with natamycin on Aspergillus niger from Shengzhou nane (Prunus salicina var. taoxingli) fruit

Study on the antifungal effect and mechanism of oregano essential oil fumigation against Aspergillus flavus

Synthesis, determination, and bio-application in cellular and biomass-bamboo imaging of natural cinnamaldehyde derivatives

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