The antifungal activity of Moroccan plants and the mechanism of action of secondary metabolites from plants

Lagrouh, F.; Dakka, Nadia; Bakri, Youssef

doi:10.1016/j.mycmed.2017.04.008

Cited by 94 publications

(79 citation statements)

References 17 publications

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“…These mechanisms mainly depend on the chemical composition of EOs. The mechanism of action class of compounds (phenols) presupposes the disruption of cell membranes and destruction of yeast mitochondria [36].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Ten Essential Oils on Several Cutaneous Drug-Resistant Microorganisms and Their Cyto/Genotoxic and Antioxidant Properties

et al. 2019

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In this study, we determined the antimicrobial activity of ten essential oils (EOs)—oregano, thyme, clove, arborvitae, cassia, lemongrass, melaleuca, eucalyptus, lavender, and clary sage—against drug-resistant microorganisms previously isolated from patients with skin infections. The essential oil compositions were determined using gas chromatography coupled to mass spectrometry (GC/MS). The assayed bacteria included Pseudomonas aeruginosa, Proteus vulgaris, Citrobacter koseri, and Klebsiella pneumoniae. Two drug-resistant yeasts (Candida albicans and Candida parapsilosis) were also involved in our survey. Oregano, thyme, cassia, lemongrass and arborvitae showed very strong antibacterial and antifungal activity against all tested strains. These results show that these essential oils may be effective in preventing the growth of the drug-resistant microorganisms responsible for wound infections. In this study, the genotoxic effects of tested essential oils on healthy human keratinocytes HaCaT were evaluated using the comet assay for the first time. These results revealed that none of the essential oils induced significant DNA damage in vitro after 24 h. Moreover, the treatment of HaCaT cells with essential oils increased the total antioxidant status (TAS) level. The obtained results indicate that EOs could be used as a potential source of safe and potent natural antimicrobial and antioxidant agents in the pharmaceutical and food industries.

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Section: Discussionmentioning

confidence: 99%

The Effect of Ten Essential Oils on Several Cutaneous Drug-Resistant Microorganisms and Their Cyto/Genotoxic and Antioxidant Properties

et al. 2019

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“…Como alternativa, há a possibilidade da descoberta de novos agentes antimicrobianos, o que é a cada dia mais escasso, sendo uma alternativa a descoberta de produtos naturais com ação farmacológica desejada. 31 Outra alternativa seria a associação de fármacos: a terapia combinada traz vantagens frente ao uso de apenas um medicamento, uma vez que, com a associação de substâncias, podem-se reduzir tanto a toxidez do agente antimicrobiano quanto seus efeitos adversos, pois será necessária uma menor dose do mesmo para alcançar maior eficácia. A associação promove também o aumento do espectro antimicrobiano, assim como o combate ao surgimento de novos organismos resistentes.…”

Section: Discussionunclassified

Antifungal Activity of Latex and Lupenonefrom Jatropha multifida L. (Euphorbiaceae)

Oliveira¹,

Lemos²,

Pereira³

et al. 2019

Rev. Virtual Quim.

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Jatropha multifida L. belongs to the family Euphorbiaceae, being popularly used in Brazil for treatment and healing of infected wounds, gastrointestinal ulcers and candidiasis. Lupenone, isolated from the hexane extract of its leaves, was submitted to the synergism test for Candida tropicalis and evaluation of its possible mechanism of antifungal action. Lupenone was able to halve the minimum inhibitory capacity (MIC) of fluconazole against C. tropicalis with possible action on the cell wall and ergosterol of the fungal membrane. The fraction derived from successive fractions of the aqueous latex residue, was analyzed by HPLC-DAD and tested in the antifungal assay against the following yeasts: Candida albicans, Candida albicans Serology A and B, Candida grablata, Candida krusei, Candida tropicalis and Cryptococcus neoformans. This fraction showed a probable catechin with moderate activity against C. tropicalis and C. grablata. The presence of triterpene and polyphenols in J. multifida may be responsible for the antifungal and cicatrizant activities presented by the species. Lupenone may be used in combination with fluconazole in the development of a new antifungal.

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“…In addition to the main anti-cancer alkaloids, which have been presented above, a number of other terpenes, or phenolic compounds, which are common in many other plant species of the Lamiaceae, Asteracea and Fabaceae families, among others, are of potential value. Many such compounds are known to possess various anti-inflammatory, anticancer, antioxidant, antidiabetic, hepatoprotective or antimicrobial properties [15][16][17][18][19][20][21][22][23]. Of these, the antibacterial properties have drawn significant interest due to the growing problem of bacterial infections around the world [92,93].…”

Section: Overproduction Of Other Secondary Metabolites In Transgenic mentioning

confidence: 99%

“…Secondary metabolites can affect cancer cells by interfering with their division, and by changing their metabolism and even the expression of selected genes. Many also have antioxidant [15,16], anti-inflammatory [17,18], antibacterial [19], antifungal [20,21], neurological [22] or hepatoprotective [23] effects. As plants represent such an important source of many secondary metabolites, there is great interest in increasing their biosynthetic rates as part of green biotechnology, which includes the use of transgenic plants or other photosynthetic organisms for industrial purposes.…”

Section: Introductionmentioning

confidence: 99%

Transgenesis as a Tool for the Efficient Production of Selected Secondary Metabolites from Plant in Vitro Cultures

Kowalczyk

Wieczfińska

Skała

et al. 2020

Plants

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The plant kingdom abounds in countless species with potential medical uses. Many of them contain valuable secondary metabolites belonging to different classes and demonstrating anticancer, anti-inflammatory, antioxidant, antimicrobial or antidiabetic properties. Many of these metabolites, e.g., paclitaxel, vinblastine, betulinic acid, chlorogenic acid or ferrulic acid, have potential applications in medicine. Additionally, these compounds have many therapeutic and health-promoting properties. The growing demand for these plant secondary metabolites forces the use of new green biotechnology tools to create new, more productive in vitro transgenic plant cultures. These procedures have yielded many promising results, and transgenic cultures have been found to be safe, efficient and cost-effective sources of valuable secondary metabolites for medicine and industry. This review focuses on the use of various in vitro plant culture systems for the production of secondary metabolites.

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The antifungal activity of Moroccan plants and the mechanism of action of secondary metabolites from plants

Cited by 94 publications

References 17 publications

The Effect of Ten Essential Oils on Several Cutaneous Drug-Resistant Microorganisms and Their Cyto/Genotoxic and Antioxidant Properties

The Effect of Ten Essential Oils on Several Cutaneous Drug-Resistant Microorganisms and Their Cyto/Genotoxic and Antioxidant Properties

Antifungal Activity of Latex and Lupenonefrom Jatropha multifida L. (Euphorbiaceae)

Transgenesis as a Tool for the Efficient Production of Selected Secondary Metabolites from Plant in Vitro Cultures

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