The antigen recognition portion of African buffalo class I MHC is highly polymorphic, consistent with a complex pathogen challenge environment, and the 3’ region suggests distinct haplotype configurations
Abstract:African buffalo (Syncerus caffer) have been distinct from the Auroch lineage leading to domestic cattle for 5 million years, and are reservoirs of multiple pathogens, that affect introduced domestic cattle. To date, there has been no analysis of the class I MHC locus in African buffalo. We present the first data on African buffalo class I MHC, which demonstrates that gene and predicted protein coding sequences are approximately 86–87% similar to that of African domestic cattle in the peptide binding region. Th… Show more
“…buffaloes to R. africae, but it is speculated that buffaloes may have similar immune responses to R. africae as they do to E. ruminantium, or they may be refractory to R. africae (Obara et al, 2022).…”
“…buffaloes to R. africae, but it is speculated that buffaloes may have similar immune responses to R. africae as they do to E. ruminantium, or they may be refractory to R. africae (Obara et al, 2022).…”
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