The Antihypertensive Action of Progesterone

Soldati, L De; Forteza, I E De; Pellegatta, Cesare; Cammarota, H

doi:10.1159/000168574

Cited by 9 publications

(5 citation statements)

References 10 publications

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“…Progesterone has been reported to exert an antihypertensive action in man (Armstrong 1959;Genest et al 1962; de Soldati et al 1966;Sammour et al 1975Sammour et al , 1982Rylance et al 1985) and in experimental hypertension (Armstrong 1959;Wambach & Higgins 1979;Susic et al 1983). The present study investigated the effect of progesterone on the onset and maintenance of ACTH-induced hypertension in the sheep.…”

Section: Discussionmentioning

confidence: 99%

“…Progesterone has been shown to lower arterial blood pressure in patients with essential hypertension (Armstrong 1959;Genest et al 1962;de Soldati et al 1966;Rylance et al 1985). Hypotensive and diuretic effects of progesterone have been reported in pre-eclamptic toxaemia (Sammour et al 1975(Sammour et al , 1982.…”

Section: Introductionmentioning

confidence: 99%

“…An antihypertensive effect of progesterone has been demonstrated in rats and dogs with renovascular hypertension (Armstrong 1959), in rats with deoxycorticosterone acetate (D0CA)-salt hypertension (Wambach & Higgins 1979), and in rats with hypertension produced by salt loading and reduction of renal mass (Susic et al 1983). Progesterone has been shown to lower arterial blood pressure in patients with essential hypertension (Armstrong 1959;Genest et al 1962;de Soldati et al 1966;Rylance et al 1985). Hypotensive and diuretic effects of progesterone have been reported in pre-eclamptic toxaemia (Sammour et al 1975(Sammour et al , 1982.…”

Section: Introductionmentioning

confidence: 99%

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Progesterone Antagonizes Development but Not Maintenance of Acth‐induced Hypertension in Sheep

Spence

Reid

Coghlan

et al. 1989

Clin Exp Pharma Physio

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1. This study investigated the effect of progesterone, which, under certain circumstances, can antagonize both the mineralocorticoid and glucocorticoid activities of steroid hormones, on the development and maintenance of adrenocorticotrophic hormone (ACTH)-induced hypertension in conscious sheep. 2. Progesterone (500 mg/day) alone, for 5 days, had no effect on blood pressure, but increased urinary Na excretion by 38 +/- 10 mmol/day (P less than 0.05) during the first 24 h. 3. Infusion of ACTH (5 micrograms/kg per day), alone, for 3 days, increased arterial pressure by 21 +/- 2 mmHg (P less than 0.001) associated with hypernatraemia, hypokalaemia, urinary Na retention, and increased fasting plasma glucose concentration. 4. Progesterone (500 mg/day) concurrently with ACTH blocked the rise in mean arterial pressure and the mineralocorticoid (urinary Na retention) but not the glucocorticoid (increase in plasma glucose concentration) effects associated with ACTH administration. 5. Progesterone (500 and 1000 mg/day) failed to reverse the hypertension and hypokalaemia in sheep pretreated for 3 days with ACTH. 6. Thus, progesterone blocked the onset but did not affect established ACTH hypertension. The mechanism by which progesterone blocked the development of ACTH hypertension appears to be related to the ability of progesterone to block the essential mineralocorticoid component of the adrenocortical steroids involved in the development of ACTH hypertension.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Progesterone Antagonizes Development but Not Maintenance of Acth‐induced Hypertension in Sheep

Spence

Reid

Coghlan

et al. 1989

Clin Exp Pharma Physio

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“…Pro gesterone treatment reduces the pressor response to periph erally administered deoxycorticosterone acetate [41] or norepinephrine [9] and attenuates primary hypertension of humans [1,8] as well as experimental renal hypertension of animals [1,8]. Estradiol treatment attenuates the elevated blood pressure of genetically hypertensive rats [20, 22].…”

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confidence: 99%

“…In addition, the possibility that fluctuations of endogenous es trogens and/or progesterone might suppress increases of Received: March 29, 1982 Accepted after revision: September 13, 1982 blood pressure resulting specifically from elevations of plasma angiotensin II (All) levels is suggested by the report that blood pressure increases of women in response to All infusions are attenuated during pregnancy, a condition in which both estrogen and progesterone levels are high [17]. Unlike the oral contraceptive steroids, the natural steroids often produce significant changes of blood pressure over shorter periods of time, e.g., as early as 2 [8] or 3 [9] days af ter steroid treatment begins. Such data suggest that synthet ic and naturally occurring ovarian steroids may affect blood pressure in different ways and support the hypothesis that naturally occurring ovarian steroids 'protect' against the development of hypertension.…”

mentioning

confidence: 99%

Pressor Responses to Central Angiotensin II, Prostaglandin E<sub>1</sub> and Prostaglandin E<sub>2</sub>

Skoog¹,

Kenney²

1983

Neuroendocrinology

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The effects of ovarian steroids on baseline blood pressure and on changes of mean arterial pressure in response to centrally administered angiotensin II, prostaglandin E₁, and prostaglandin E2 were examined. Ovariectomized rats treated with estradiol or progesterone showed no change of resting blood pressures relative to oil-treated, ovariectomized controls. Intracerebroventricular injections of prostaglandin E₁, prostaglandin E₂ or angiotensin II produced significant elevations of arterial pressure of oil-treated rats. Either estradiol or progesterone treatment significantly attenuated pressor responses to prostaglandin E₁ but not to prostaglandin E₂ or angiotensin II injections. The duration of the blood pressure increase of estradiol-treated rats in response to angiotensin II was reduced when the animals did not have access to drinking water during the pressure monitoring session but not when water was available. These results’suggest that the effects of ovarian steroids in modulating pressor responses are dependent on the particular factors which initiate the pressure increases. Possible mechanisms underlying this ovarian-steroid action are discussed.

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Progesterone: An overview and recent advances

Aufrère

Benson

1976

Journal of Pharmaceutical Sciences

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The Antihypertensive Action of Progesterone

Cited by 9 publications

References 10 publications

Progesterone Antagonizes Development but Not Maintenance of Acth‐induced Hypertension in Sheep

Progesterone Antagonizes Development but Not Maintenance of Acth‐induced Hypertension in Sheep

Pressor Responses to Central Angiotensin II, Prostaglandin E<sub>1</sub> and Prostaglandin E<sub>2</sub>

Progesterone: An overview and recent advances

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