The antihypertensive effect of arginine

Vasdev, Sudesh; Gill, Vicki

doi:10.1055/s-0031-1278274

Cited by 43 publications

(36 citation statements)

References 215 publications

(304 reference statements)

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“…Our finding is consistent with a previous report which indicated that L-arginine levels are reduced in Pre-eclampsia (PE), a syndrome of pregnancy-induced hypertension [30]. Arginine deficiency or lack of availability, and changes in arginine metabolism, has the potential to contribute to increased blood pressure and endothelial cell dysfunction [31].…”

Section: Discussionsupporting

confidence: 93%

“…Although the etiology of hypertension has a genetic component, lifestyle factors such as diet play an important role. A diet rich in protein containing the semi-essential amino acid, arginine, and arginine treatment, lowers blood pressure in humans and in animal models [31]. The Dietary Approaches to Stop Hypertension (DASH) study demonstrated that the DASH diet, rich in vegetables, fruits and low-fat dairy products; low in fat; and including whole grains, poultry, fish and nuts, lowered blood pressures.…”

Section: Discussionmentioning

confidence: 99%

“…The Dietary Approaches to Stop Hypertension (DASH) study demonstrated that the DASH diet, rich in vegetables, fruits and low-fat dairy products; low in fat; and including whole grains, poultry, fish and nuts, lowered blood pressures. A diet rich in protein containing the semi essential amino acid, arginine, and arginine treatment lowers blood pressure in humans and in animal models [31].…”

Section: Discussionmentioning

confidence: 99%

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L-Arginine Levels among Hypertensive Patients in Sokoto, North Western Nigeria

Erhabor¹,

Ibrahim²,

Ahmed³

et al. 2017

OJBD

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Hypertension is a major public health problem that adversely affects the health status of individuals, families and communities. L-arginine levels of a total of 90 consecutively-recruited hypertensive subjects and 50 age-matched non-hypertensive controls were studied. Plasma from subjects and control participants were analyzed for L-arginine. The mean values of L-arginine level were significantly lower among the hypertensive subjects which are (174.33 ± 78.31 µmol/L) compared to those of the 50 non-hypertensive controls (237.82 ± 261.16 µmol/L) (p = 0.04). There was no statistically significant difference in the L-arginine levels of hypertensive subjects based on gender, age and ethnicity (p = 0.87, 0.23 and 0.57) respectively. The L-arginine level was significantly higher among married hypertensive subjects (181.71 ± 78.17 µmol/L) compared to single or unmarried subjects (130.62 ± 65.99 µmol/L) (p = 0.03). The mean value of L-arginine level was significantly higher among hypertensive subjects with mild blood pressure (187.63 ± 77.93 µmol/L) compared to those with high blood pressure (156.93 ± 76.31 µmol/L). The difference however was not statistically significant (p = 0.05). The findings from this study confirm that the level of L-arginine is lower among hypertensive subjects compared to non-hypertensive controls. Age, gender and ethnicity did not have a significant effect on the L-arginine levels of hypertensive subjects. L-arginine level was significantly lower among single hypertensive patients and those with markedly raised blood pressure. It is recommended the L-arginine supplement be prescribed to hypertensive patient as a prophylactic measure. There is a need to enlighten hypertensive patients in the area on the need to maintain a balanced diet containing sufficient level of L-arginine.How to cite this paper: Erhabor, O., Ibra-

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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L-Arginine Levels among Hypertensive Patients in Sokoto, North Western Nigeria

Erhabor¹,

Ibrahim²,

Ahmed³

et al. 2017

OJBD

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“…18 Furthermore, high content of antioxidants and arginine amino acid in the DASH diet may improve metabolic status through decreased NADPH oxidase activity 19 and reduced angiotensin II levels. 20 Despite these findings, to our knowledge, data on effects of the DASH diet on weight loss, AMH and metabolic profiles in women with PCOS is limited. We hypothesized that the DASH diet might benefit in patients with PCOS to improve their metabolic profiles.…”

mentioning

confidence: 99%

The effects of dietary approaches to stop hypertension diet on weight loss, anti‐Müllerian hormone and metabolic profiles in women with polycystic ovary syndrome: A randomized clinical trial

Foroozanfard

Rafiei

Samimi

et al. 2017

Clinical Endocrinology

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“…Of note, L-arginine is a semi-essential amino acid, which is obtained from natural dietary sources and can be produced endogenously in various organs [11]. L-arginine plays a vital role in various physiological functions and, prominently, in maintaining vascular homeostasis [10].…”

Section: Introductionmentioning

confidence: 99%

Norvaline reduces blood pressure and induces diuresis in rats with inherited stress-induced arterial hypertension

Gilinsky

Polityko

et al. 2019

Preprint

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Growing evidence suggests that increased arginase activity affects vital bioprocesses in various systems and universally mediates the pathogenesis of numerous metabolic diseases. The adverse effects of arginase are associated with a severe decline in L-arginine bioavailability, which leads to nitric oxide synthase substrate insufficiency, uncoupling, and, eventually, to superoxide anion generation and substantial reduction of nitric oxide (NO) synthesis. In cooperation, it contributes to chronic oxidative stress and endothelial dysfunction, which might lead to hypertension and atherosclerosis.Recent preclinical investigations point to arginase as a promising therapeutic target in ameliorating metabolic and vascular dysfunctions. In the present study, adult rats with inherited stress-induced arterial hypertension (ISIAH) were used as a model of hypertension. Wistar rats served as normotensive controls. Experimental animals were intraperitoneally administered for seven days with non-proteinogenic amino acid L-norvaline (30 mg/kg/day), which is a potent arginase inhibitor, or with the vehicle. Blood pressure (BP), body weight, and diuresis were monitored. The changes in blood and urine levels of creatinine, urea, and NO metabolites were analyzed.We observed a significant decline in BP and induced diuresis in ISIAH rats following the treatment. The same procedure did not affect the BP of control animals. Remarkably, the treatment had no influence upon glomerular filtration rate in two experimental groups, just like the daily excretion of creatinine and urea. Conversely, NO metabolites levels were amplified in normotonic but not in hypertensive rats following the treatment.The data indicate that L-norvaline is a potential antihypertensive agent, and deserves to be clinically investigated. Moreover, we suggest that changes in blood and urine are causally related to the effect of L-norvaline upon the BP regulation.

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The antihypertensive effect of arginine

Cited by 43 publications

References 215 publications

L-Arginine Levels among Hypertensive Patients in Sokoto, North Western Nigeria

L-Arginine Levels among Hypertensive Patients in Sokoto, North Western Nigeria

The effects of dietary approaches to stop hypertension diet on weight loss, anti‐Müllerian hormone and metabolic profiles in women with polycystic ovary syndrome: A randomized clinical trial

Norvaline reduces blood pressure and induces diuresis in rats with inherited stress-induced arterial hypertension

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