The Antihypertensive Effect of the Fixed Combination of Amlodipine and Lisinopril in Patients With Coronary Heart Disease After Coronary Artery Bypass Grafting

Panov, A.V.; Alugishvili, M. Z.; Abesadze, I. T.; Lokhovinina, N. L.; Korzhenewskaya, K V; Titenkov, I V; Kuleshov, E V; Duplyakov, D. V.; Hohlunov, S M; Kryukov, A. V.; Либис, Р. А.; Isayeva, E N; Басырова, И. Р.; Сафонова, Д. В.

doi:10.18565/cardio.2015.6.27-33

Cited by 6 publications

(16 citation statements)

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“…Включенные в анализ исследования существенно различались по размерам выборки: некоторые включали от нескольких сотен до нескольких тысяч человек [8][9][10][11][18][19][20], другие -намного меньше, от 30 до 70 человек [12,14,16,17,21,22,24,25]. Период наблюдения также значительно варьировал -от 6 нед [15] до 12 мес [9,10,22,25]. Одно исследование имело общую продолжительность 4 года [18], но для анализа были доступны только данные за 3 мес наблюдения.…”

Section: Discussionunclassified

“…Наиболее часто для повышения приверженности применялась оптимизация режима приема лекарств, которая заключалась в назначении ФК вместо приема нескольких лекарственных препаратов [7,8,11,[16][17][18][20][21][22]26]. Показана эффективность данного подхода -увеличение среднего балла по шкале МГ-4, доли приверженных пациентов по шкале МГ-4 и по данным оригинального опросника, повышение комплаентности при подсчете таблеток, что согласуется результатами аналогичных зарубежных исследований [27].…”

Section: Discussionunclassified

“…Прием нескольких антигипертензивных препаратов (2 и более) сопровождался снижением приверженности [8]. Adherence to Antihypertensive Therapy Приверженность к антигипертензивной терапии [7,8,11,[16][17][18][20][21][22]. В одном исследовании применяли мотивационную технологию: пациентам демонстрировали электронную версию шкалы SCORE, при этом врач показывал пациенту возможность снижения сердечно-сосудистого риска при выполнении рекомендаций по отказу от курения, контролю АД и снижению уровня холестерина [23].…”

Section: материал и методыunclassified

“…Влияние приема ФК антигипертензивных препаратов на приверженность оценивалось в 7 нерандомизированных исследованиях [7,8,11,[18][19][20]22]. Применение ФК ассоциировалось со значительным увеличением приверженности, измеренной по шкале МГ-4, по сравнению с исходным уровнем [7,8,11,[18][19][20].…”

Section: нерандомизированные интервенционные исследованияunclassified

“…При использовании разработанного опросника также была показана стабильно высокая приверженность при лечении ФК (ингибитора ангиотензин-превращающего фермента и блокатора кальциевых каналов) у 97 и 93% больных через 6 и 12 мес наблюдения, соответственно [22].…”

Section: нерандомизированные интервенционные исследованияunclassified

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Adherence to Antihypertensive Therapy: A Systematic Review of Russian Prospective Studies from 2000 to 2019

Bochkareva¹,

Butina²,

Kim³

et al. 2020

Racionalʹnaâ farmakoterapiâ v kardiologii

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Russia belongs to countries with a high prevalence of arterial hypertension (AH), which is the main cause of premature death in the Russian population. The level of blood pressure (BP) is controlled in less than a third of patients, which may be due to poor adherence to medical recommendations and irregular medication. The manuscript provides a review of studies evaluating the effectiveness of measures to improve adherence to antihypertensive therapy (AHT).Aim. To prepare a systematic review of Russian studies to assess the effectiveness of measures to increase adherence to AHT, to determine/describe the main directions of the intervention and the methodological level.Material and methods. The search for full-text articles on adherence to AHT published in Russian in the period from 2000 to 2019 was carried out in the main Russian and international electronic databases eLIBRARY.ru, Embase, Russian Medicine, MEDLINE. Of the 563 publications found, 20 were included in the review.Results. In 14 studies, adherence was assessed using the 4-item Morisky Medication Adherence Scale (MMAS-4), other studies used bespoke questionnaires or pill counts. Two studies examined factors associated with adherence. The observation period was up 6 weeks to 12 months, the number of participants is 30-2435 people. A higher adherence was noted in women, people over 50 years old, with higher education, working, with concomitant diabetes mellitus and a history of myocardial infarction. Patient education was effective interventions to improve adherence (in particular, in studies, improvement on the MMAS-4 from 1.8 to 3.9 points, p=0.0002 or from 2.80 to 3.79 points, p<0.0001), telephone reminders (p<0.0001), training in self-measurement of blood pressure (p<0.05) and fixed combinations of drugs (p<0.05).Conclusion. The most effective ways to improve adherence are patient education and the use of drugs fixed combinations. In most studies, subjective methods of adherence assessing were used.

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Section: Discussionunclassified

Section: материал и методыunclassified

Section: нерандомизированные интервенционные исследованияunclassified

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Adherence to Antihypertensive Therapy: A Systematic Review of Russian Prospective Studies from 2000 to 2019

Bochkareva¹,

Butina²,

Kim³

et al. 2020

Racionalʹnaâ farmakoterapiâ v kardiologii

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Adherence to antihypertensive medication in Russia: a scoping review of studies on levels, determinants and intervention strategies published between 2000 and 2017

et al. 2019

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Background Arterial hypertension (HT) is common in the Russian adult population, with half of affected individuals inadequately controlled. Low adherence to medication seems likely to be a factor. We report a scoping review of studies on adherence to antihypertensive therapy (AHT) in Russia to determine the extent of research undertaken, the frequency of adherence among adults diagnosed with HT, methodologies used in the studies, and their ability to describe determinants of adherence. Methods A scoping review of published studies that have assessed adherence to AHT in Russian HT patients searched the main Russian and international electronic databases eLIBRARY.ru, Russian Medicine, Embase, MEDLINE for full-text reports published in the Russian language between 2000 and 2017. The last search was on November 28, 2017. Among 520 reports identified, 31 were included in the review. Results Eighteen studies assessed adherence using the 4-item Morisky Medication Adherence Scale (MMAS-4); others used bespoke questionnaires or pill counts. 25 studies assessed levels of adherence, 11 examined its determinants, and 18 examined intervention strategies. The proportion of “adherent” patients varied from 11 to 44% using the MMAS-4, from 23 to 74% when using bespoke questionnaires, and from 5 to 43% when using pill counts. Adherence was associated with sociodemographic factors, access to free drugs provided through the Medicine Assistance Scheme (MAS), use of home blood pressure (BP) monitoring, anxiety, and comorbidity. There was no evidence that adherence was associated with income or physical activity. Evidence of an association between MAS, grade of HT, or experience of hypertensive crisis was inconclusive. Various methods to improve adherence were studied including patient education (improved from 1.8 to 3.9 points, p = 0.0002 or 2.80 to 3.79 points, p < 0.0001 measured by the MMAS-4), telephone reminders (p < 0.0001), training in home BP monitoring (p < 0.05), and use of fixed-dose combinations (p < 0.05). Conclusions The main determinants of adherence to AHT are sociodemographic characteristics, the severity of HT, and presence of comorbidity. Patient education and use of fixed-dose combinations of drugs were identified as most important for improving adherence. Most studies assessing adherence use self-reported methods so there is a need for greater use of objective methods. Trial registration This scoping review has not been registered.

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Aspects of economic efficiency of surgical myocardial revascularization

Kuzmichkina¹,

Serebryakova²

2021

Profil. med.

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The Antihypertensive Effect of the Fixed Combination of Amlodipine and Lisinopril in Patients With Coronary Heart Disease After Coronary Artery Bypass Grafting

Cited by 6 publications

References 0 publications

Adherence to Antihypertensive Therapy: A Systematic Review of Russian Prospective Studies from 2000 to 2019

Adherence to Antihypertensive Therapy: A Systematic Review of Russian Prospective Studies from 2000 to 2019

Adherence to antihypertensive medication in Russia: a scoping review of studies on levels, determinants and intervention strategies published between 2000 and 2017

Aspects of economic efficiency of surgical myocardial revascularization

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