The antimicrobial activity of Hwangheuk-san and synergy effect with oxacillin against methicillin-resistant Staphylococcus aureus

Abstract

Objectives : Hwangheuk-san is a complex prescription composed of oriental traditional medicine and has been reported for antioxidant, antimicrobial and anticancer effects in the recent study. Methicillin-resistant Staphylococcus aureus (MRSA) is one of important causes of fatal infectious diseases such as septicemia, endocarditis, toxic shock syndrome, pneumonia, skin and soft tissue infections (SSTIs). S. aureus is reported as being for a variety of human diseases and its epidemiological relevance is mainly due to their ability of becoming highly resistant to common antimicrobials such as tetracycline, penicillin, cphalosporin and aminoglycoside. The objective of this study is to determine *

The sesquiterpene lactone polymatin B from Smallanthus sonchifolius induces different cell death mechanisms in three cancer cell lines

“…Different biological activities of some of the SLs isolated from S. sonchifolius have been previously reported, that include antibacterial, antifungal, cytotoxic, anti-inflammatory, hypoglycemic, and the inhibition of nitric oxide production (Choi et al, 2010;Genta et al, 2010;Schorr et al, 2007;Siriwan et al, 2011a). As part of previous work with SLs isolated from S. sonchifolius, the antitrypanosomal activity of enhydrin (1), uvedalin (2) and polymatin B (3) on Trypanosoma cruzi was reported (Frank et al, 2013).…”