The antimicrobial activity of Physalis peruviana L.

Göztok, Ferda; Zengin, Fikriye Kirbağ

doi:10.17678/beuscitech.47134

Cited by 10 publications

(10 citation statements)

References 11 publications

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“…In studies developed by Göztok and Zengin, (2013) and Çakir et al (2014) (Figure 1). A disadvantage of the lyophilizate is that apart from being expensive, in the freezedrying process some of the bioactive properties of the plants are lost (Otobone et al, 2007).…”

Section: Screening Of Antibacterial Activitymentioning

confidence: 90%

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Antibacterial Effects of Uvilla (Physalis peruviana L.) extracts against Listeria spp. Isolated from Meat in Ecuador

Cueva¹,

León²,

Yanchaliquín³

et al. 2017

Int.J.Curr.Microbiol.App.Sci

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Section: Screening Of Antibacterial Activitymentioning

confidence: 90%

“…These plants have also potential medicinal properties like anti-bacterial, antiinflammatory, and antioxidant properties (Corrales-Bernal et al, 2015;Göztok and Zengin, 2013;Yen, et al, 2010). Besides this plant is known to induce apoptosis in different phases and has anti-cancer activity (Yen et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Effects of Uvilla (Physalis peruviana L.) extracts against Listeria spp. Isolated from Meat in Ecuador

Cueva¹,

León²,

Yanchaliquín³

et al. 2017

Int.J.Curr.Microbiol.App.Sci

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“…The identification of the plant was determined. 4 Fruit, seed, body, leaf and root extracts of the P. peruviana were separately prepared. The crude extracts were stored at -20 °C until used.…”

Section: Plant Materials and Extract Preparationmentioning

confidence: 99%

Antioxidant, Antimicrobial Activities and Phenolic and Chemical Contents of Physalis peruviana L. from Trabzon, Turkey

Ertürk¹,

Ayvaz²,

Can³

et al. 2017

IJPER

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Background: Goldenberry (Physalis peruviana L.) is one of the most promising exotic fruits in terms of its biological capacity. Objective: In this work, ethanol extracts of the different parts (fruit, seed, root, body and leaf) of the P. peruviana were investigated in terms of their antioxidant and antimicrobial activity. Furthermore total phenolic and flavonoid contents, phenolic analysis and volatile compound analysis were exhibited. Method: Total phenolic and flavonoid contents were calculted as gallic acid and quercetin equivalent respectively. Antioxidant activity were studied based on DPPH free radical scavenging activity. Antimicrobial activity were determined by disc diffusion method against several bacteria, a fungi and a yeast. Analysis for phenolic and volatile compounds were exhibited by using HPLC and GC-MS respectively. Results: The values obtained for the total phenolic and flavonoid contents and SC 50 values calculated for DPPH scavenging activities were compatible with each other. Extract prepared from the seed had the highest phenolic (4.956±0.001 mg GA/g sample) and flavonoid content (0.737±0.034 mg QE/g sample). Gallic acid and ferulic acid were detected in all extracts. The most volatile species (190 pieces) detected in root extract. Seed and fruit were the most effective parts of the P. peruviana in terms of their antimicrobial activity. Conclusion: According to obtained results it has been demonstrated that P. peruviana from Trabzon had good useful properties for human health and it would be useful to carry out further researchs on it.

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“…Withanolides, secondary metabolites primarily occurring in plants of family Solanaceae, have diverse biological properties like anti‐inflammatory antitumor, cytotoxicity, hepatotoxicity, and antimicrobial . Sang‐ngern et al isolated some withanolides from aerial parts of Physalis peruviana (Solanaceae) and evaluated in LPS‐activated murine macrophage RAW‐264.7 cells.…”

Section: Natural Inos Inhibitorsmentioning

confidence: 99%

Inducible nitric oxide synthase inhibitors: A comprehensive update

Minhas

Bansal

2019

Medicinal Research Reviews

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Inducible nitric oxide synthase (iNOS), which is expressed in response to bacterial/proinflammatory stimuli, generates nitric oxide (NO) that provides cytoprotection. Overexpression of iNOS increases the levels of NO, and this increased NO level is implicated in pathophysiology of complex multifactorial diseases like Parkinson's disease, Alzheimer's disease, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. Selective inhibition of iNOS is an effective approach in treatment of such complex diseases. L-Arginine, being a substrate for iNOS, is the natural lead to develop iNOS inhibitors. More than 200 research reports on development of nitric oxide synthase inhibitors by different research groups across the globe have appeared in literature so far. The first review on iNOS, in 2002, discussed the iNOS inhibitors under two classes that is, amino acid and non-amino acid derivatives. Other review articles discussing specific chemical classes of iNOS inhibitors also appeared during last decade. In the present review, all reports on both natural and synthetic iNOS inhibitors, published 2002 onwards, are studied, classified, and discussed to provide comprehensive information on iNOS inhibitors. The synthetic inhibitors are broadly classified into two categories that is, arginine and non-arginine analogs. The latter are further classified into amidines, five-or six-membered heterocyclics, fused cyclics, steroidal type, and chalcones analogs. Structures of the most/significantly potent compounds from each report are provided to know the functional groups important for incurring iNOS inhibitory activity and selectivity. This review is aimed to provide a comprehensive view to the medicinal chemists for rational designing of novel and potent iNOS inhibitors. K E Y W O R D S arginine, inflammation, inhibitors, multifactorial disease, nitric oxide 1 | INTRODUCTION Nitric oxide (NO) is a relaxing factor derived from endothelium, which is responsible for neuronal transmission, cardiovascular, gastrointestinal, genitourinary, respiratory, antipathogenic, and antitumor responses. The production of NO is effected by nitric oxide synthase (NOS) through catalysis of NADPH-dependent oxidation of L-arginine (the substrate). 1NOS exists in three distinct isoforms, depending on the site of its existence that is, neuronal NOS (nNOS, type I), inducible or inflammatory NOS (iNOS, type II) and endothelial NOS (eNOS, type III). Constitutive NOS are regulated by the binding of calcium-calmodulin protein, whereas iNOS is transcriptionally regulated and calcium-calmodulin independent. NO plays both physiological and pathological roles depending on the magnitude and duration of its production. 2 The physiological roles of NO are executed by soluble guanylate cyclase. Indeed, NO activates it, with the consequent increase of cyclic guanosine-3′,5′-monophosphate (cGMP) level, which subsequently activates intracellular effector molecules, cGMPdependent protein kinases, cGMP-gated ion channels, and cGMP-regulated phosphodiesteras...

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The antimicrobial activity of Physalis peruviana L.

Cited by 10 publications

References 11 publications

Antibacterial Effects of Uvilla (Physalis peruviana L.) extracts against Listeria spp. Isolated from Meat in Ecuador

Antibacterial Effects of Uvilla (Physalis peruviana L.) extracts against Listeria spp. Isolated from Meat in Ecuador

Antioxidant, Antimicrobial Activities and Phenolic and Chemical Contents of Physalis peruviana L. from Trabzon, Turkey

Inducible nitric oxide synthase inhibitors: A comprehensive update

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