The Antimicrobial Activity of the Essential Oils of FourJuniperus Species Growing Wild in Greece

Stassi, V.; Verykokidou, E.; Loukis, A.; Harvala, Catherine; Philianos, S.

doi:10.1002/(sici)1099-1026(199601)11:1<71::aid-ffj536>3.0.co;2-9

Cited by 36 publications

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“…According to Aligiannis et al (2001) [ 63 ], who proposed a classification of plant materials based on MIC results (strong inhibitors: MIC up to 500 μg/mL, moderate inhibitors: MIC between 600 and 1500 μg/mL, weak inhibitors: MIC above 1600 μg/mL), all essential oils exhibited strong-to-moderate antimicrobial activity, while some essential oils (Jf-C, Jcc-C, Jt-L and Jt-C) exhibited extremely strong activity (MIC up to 90 μg/mL) against Gram-positive strains and one yeast strain (Jt-L and Jt-C). A stronger activity was observed in the essential oils of the cones and especially against Gram-positive strains of Staphylococcus and Streptococcus compared with the leaves, which is consistent with previous results [ 15 , 64 , 65 ]. In particular, the essential oils of cones of J. foetidissima , J. communis , J. drupacea and J. turbinata showed a better effect, while the essential oils of leaves or cones of J. macrocarpa , J. sabina and J. excelsa did not show strong antibacterial activity.…”

Section: Resultssupporting

confidence: 92%

“…A stronger activity was observed in the essential oils of the cones and especially against Gram-positive strains of Staphylococcus and Streptococcus compared with the leaves, which is consistent with previous results [15,64,65]. In particular, the essential oils of cones of J. foetidissima, J. communis, J. drupacea and J. turbinata showed a better effect, while the essential oils of leaves or cones of J. macrocarpa, J. sabina and J. excelsa did not show strong antibacterial activity.…”

Section: Data Availability Statementsupporting

confidence: 90%

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Volatiles of All Native Juniperus Species Growing in Greece—Antimicrobial Properties

Fotiadou,

Panou,

Graikou

et al. 2023

Foods

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Juniper (Juniperus L., Cupressaceae Bartlett) trees are of high commercial value, as their essential oils are widely applied in the food and cosmetic industries due to their bioactivities. The genus Juniperus comprises eight species in Greece, and in the current work, we report the chemical analyses of their volatiles (GC-MS) obtained from the leaves and cones of all indigenous species found in the country, as well as their antimicrobial properties. The studied species were J. oxycedrus L., J. excelsa M. Bieb., J. foetidissima Willd., J. communis L., J. macrocarpa Sibth. & Sm., J. turbinata Guss., J. sabina L. and J. drupacea Labill., and a total of 164 constituents were identified. Monoterpenes, followed by sesquiterpenes, appeared as the dominant compounds in all investigated species. Most of the studied essential oils belonged to the α-pinene chemotype, with amounts of α-cedrol, sabinene, limonene and myrcene among the abundant metabolites, except for J. sabina, which belonged to the sabinene chemotype. Through antimicrobial tests, it was observed that the essential oils of most of the cones showed better activity compared with the respective leaves. The essential oils of the cones of J. foetidissima, J. communis and J. turbinata showed the strongest activity against the tested microorganisms. Additionally, in these three species, the content of thujone, which is a toxic metabolite found in essential oils of many Juniperus species, was considerably low. Taking into consideration the chemical profile, safety and antimicrobial activity, these three Greek Juniperus species seemed to provide the most promising essential oils for further exploitation in the food and cosmetics industries.

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Section: Resultssupporting

confidence: 92%

Section: Data Availability Statementsupporting

confidence: 90%

Volatiles of All Native Juniperus Species Growing in Greece—Antimicrobial Properties

Fotiadou,

Panou,

Graikou

et al. 2023

Foods

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Bioactive Constituents ofJuniperus turbinataGuss. from La Maddalena Archipelago

Venditti

Maggi

Quassinti

et al. 2018

Chemistry & Biodiversity

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A comprehensive phytochemical study of Juniperus turbinata (Cupressaceae) collected from La Maddalena Archipelago (Sardinia, Italy) is reported. Both the essential oil and the ethanolic extract obtained from the aerial parts were analyzed. The essential oil appears to belong to a new chemotype compared to other Mediterranean juniper accessions, as it was favored by geographic isolation of the isles. It showed a low content of monoterpene hydrocarbons and α-terpineol, ent-manoyl oxide, 1,10-di-epi-cubenol as the major constituents. The ethanolic fraction contained mainly diterpenoids. Among these, 15-formyloxyimbricatolic acid (7) is a new natural product since it has hitherto been obtained only by synthetic route. The phenolic fraction contained biflavonoids: cupressuflavone (9), followed by minor amounts of amentoflavone (10) and hinokiflavone (11). The essential oil and six purified compounds (1 - 4, 8 and 9) were assessed for biological activities, namely antioxidant (assessed by DPPH , ABTS and FRAP methods) and cytotoxic effects towards selected human tumor cell lines (MDA-MB 231, A375 and HCT116 cells). Compound 3 exhibited higher radical scavenging activity against ABTS radical than the reference Trolox. Noteworthy, compound 8 showed powerful effects towards tumor cell lines, with IC values in the range of 0.060 - 0.201 μm, which make it a promising anticancer drug candidate.

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Juniperus phoenicea var. turbinata (Guss.) Parl. Leaf Essential Oil Variability in the Balkans

Rajčević

Labus

Dodoš

et al. 2018

Chemistry & Biodiversity

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In the present work, the leaf essential oil from 97 individuals of Juniperus phoenicea var. turbinata (Guss.) Parl. from the Balkan Peninsula was analyzed. The essential oil was dominated by monoterpene hydrocarbons (45.5 - 71.8%), of which α-pinene was the most abundant in almost all of the samples (38.2 - 55.8%). Several other monoterpenes and sesquiterpenes were also present in relatively high abundances in samples such as myrcene, δ-3-carene, β-phellandrene, α-terpinyl acetate, (E)-caryophyllene and germacrene D. Multivariate statistical analysis suggested the existence of three possible chemotypes based on the abundance of the four components. Even though the intrapopulation variability was high, discriminant analysis (DA) was able to separate populations. DA showed high separation between western and eastern populations but also grouped geographically closer populations along the west Balkan shoreline. The potential influence of the climate on the composition of the essential oil was also studied.

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The Antimicrobial Activity of the Essential Oils of FourJuniperus Species Growing Wild in Greece

Cited by 36 publications

References 0 publications

Volatiles of All Native Juniperus Species Growing in Greece—Antimicrobial Properties

Volatiles of All Native Juniperus Species Growing in Greece—Antimicrobial Properties

Bioactive Constituents ofJuniperus turbinataGuss. from La Maddalena Archipelago

Juniperus phoenicea var. turbinata (Guss.) Parl. Leaf Essential Oil Variability in the Balkans

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