The Antimicrobial Effectiveness of Clindamycin in Diseases of the Oral Cavity

Zetner, K; Thiemann, Gerald

doi:10.1177/089875649301000204

Cited by 11 publications

(5 citation statements)

References 2 publications

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“…In all advanced cases of periodontal disease, appropriate dental care should be undertaken to avoid further disease development. It has been reported that P. gulae is susceptible to clindamycin, which has been approved for the treatment of periodontal disease in dogs ( 14 , 15 ). Recently, our group showed that combination therapy using clindamycin and IFN-α treatment can improve periodontal condition and reduce P. gulae in dogs ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

Possible association of fimA genotype of Porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogs

Shirahata

Iwashita²,

Sasaki³

et al. 2023

Front. Vet. Sci.

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Previous research has demonstrated that Porphyromonas gulae (P. gulae) significantly contributes to the development of periodontal disease in dogs. Porphyromonas gulae is divided into three subtypes according to the 41-kDa filamentous appendage (fimA), defined as types A, B, and C. This study aimed to elucidate the association between fimA type of P. gulae with the number of permanent teeth, reflecting the severity of periodontal disease. Two hundred twenty-five dogs were categorized by P. gulae fimA type as negative, type A dominant, type B dominant, and type C dominant. The stage of periodontal disease in P. gulae-positive dogs increased with age, particularly in type C dominant dogs. Correspondingly, the number of permanent teeth in P. gulae fimA type C-dominant dogs was significantly lower than that of P. gulae-negative dogs, suggesting there is a significant association between fimA type of P. gulae and the number of permanent teeth resulting from the development of periodontal disease.

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Section: Discussionmentioning

confidence: 99%

Possible association of fimA genotype of Porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogs

Shirahata

Iwashita²,

Sasaki³

et al. 2023

Front. Vet. Sci.

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“…Inhibitory effects of clindamycin on growth of P. gulae strains. Clindamycin has been used for the treatment of periodontal disease in dogs 19 . Therefore, we analysed whether clindamycin was effective for P. gulae with each fimA genotype.…”

Section: Resultsmentioning

confidence: 99%

Inhibition of Porphyromonas gulae and periodontal disease in dogs by a combination of clindamycin and interferon alpha

Nomura

Inaba

Yasuda³

et al. 2020

Sci Rep

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Porphyromonas gulae is a major periodontal pathogen in dogs, which can be transmitted to their owners. A major virulence factor of P. gulae consists of a 41-kDa filamentous appendage (FimA) on the cell surface, which is classified into three genotypes: A, B, and C. Thus far, inhibition of periodontal disease in dogs remains difficult. The present study assessed the inhibitory effects of a combination of clindamycin and interferon alpha (IFN-α) formulation against P. gulae and periodontal disease. Growth of P. gulae was significantly inhibited by clindamycin; this inhibition had a greater effect on type C P. gulae than on type A and B isolates. In contrast, the IFN-α formulation inhibited the expression of IL-1β and COX-2 elicited by type A and B isolates, but not that elicited by type C isolates. Furthermore, periodontal recovery was promoted by the administration of both clindamycin and ifn-α formulation to dogs undergoing periodontal treatment; moreover, this combined treatment reduced the number of fimA genotypes in oral specimens from treated dogs. these results suggest that a combination of clindamycin and ifn-α formulation inhibit P. gulae virulence and thus may be effective for the prevention of periodontal disease induced by P. gulae.

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“…Antibiotic therapy is commonly used as part of the treatment for canine periodontal disease. According to previous studies, preoperative treatment with clindamycin prior to removal of calculus using an ultrasonic scaler can reduce aerosolized bacteria [23] . In our study, in spite of the previous antibiotherapy in some patients, strong bacterial contamination of the released aerosols was still present, suggesting that antibiotherapy per se is not a warranty of less contaminated aerosols.…”

Section: Discussionmentioning

confidence: 99%

Bacterial Aerosols Released During Dental Ultrasonic Scaling in Dogs

Delgado¹,

Dias²

2020

DOBCR

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Periodontal disease is a high prevalent and multi-factorial oral disease in dogs and ultrasonic scaling is used to remove dental plaque and calculus, releasing contaminated aerosols, which may represent a hazard to animal and human health. This study aimed to identify the microorganisms present in aerosols produced during dental scaling of canine patients. A random sample of 15 dogs with periodontal disease was included, and aerosol samples were collected, incubated, and isolated bacteria were identified. Dogs without previous antibiotic treatment (n=4) and dogs that received systemic antibiotics up to two weeks before to dental scaling and polishing, either amoxicillin and clavulanic acid (n=3), or a combination of metronidazole and spiramycin (n=8), were included in the study. The highest percentage of pathogenic bacteria present corresponded to Pseudomonas spp. (20%), followed by Staphylococcus spp. (13%) and Escherichia coli (10%). The most prevalent bacteria identified in the non-treated group was Pseudomonas spp. Within the group subject to prior antibiotherapy, the predominant bacterial species was also Pseudomonas spp. Followed by Staphylococcus spp. In spite of previous antibiotherapy, strong bacterial contamination was still present, suggesting that this is not a warranty of less contamination of the released aerosols. The bacteria identified in this study represent a serious hazard to public and animal health, so strict hygiene and prevention measures during ultrasonic scaling in dogs are mandatory.

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The Antimicrobial Effectiveness of Clindamycin in Diseases of the Oral Cavity

Cited by 11 publications

References 2 publications

Possible association of fimA genotype of Porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogs

Possible association of fimA genotype of Porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogs

Inhibition of Porphyromonas gulae and periodontal disease in dogs by a combination of clindamycin and interferon alpha

Bacterial Aerosols Released During Dental Ultrasonic Scaling in Dogs

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