The antimicrobial effects in vivo of minocycline, doxycycline and tetracycline in humans

Leyden, James J.; Kaidbey, Kays H.; Gans, Eugene H.

doi:10.3109/09546639609089553

Cited by 32 publications

(19 citation statements)

References 5 publications

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“…Therapies which reduce the population of P. acnes are beneficial, whilst the emergence of antibiotic‐resistant organisms often results in therapeutic failure. 1–5 Twenty years ago, it was virtually impossible to make P. acnes resistant to antibiotics, but this organism is now frequently resistant to erythromycin, and resistance to clindamycin and tetracyclines is increasing. 3–5 …”

Section: Discussionmentioning

confidence: 99%

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A pilot study on bacterial viability in acne. Assessment using dual flow cytometry on microbials present in follicular casts and comedones

et al. 1998

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Section: Discussionmentioning

confidence: 99%

“…For years, specific antibiotics were used to treat acne with success; 1 , 2 however, bacterial resistance to acne antibiotherapy has emerged and has been increasingly documented during the paste decade. 1 , 3 , 4 ‐ 5 This shift in bacterial sensibility has been reported in association with treatment failure.…”

mentioning

confidence: 99%

A pilot study on bacterial viability in acne. Assessment using dual flow cytometry on microbials present in follicular casts and comedones

et al. 1998

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“…60,65,66 Comparative studies are limited, but the second-generation tetracyclines, doxycycline and minocycline, are preferred because of pharmacokinetic advantages allowing for once-daily administration in most cases, greater lipophilicity that is believed to augment follicular penetration, and lower prevalence of resistant P acnes strains as compared with tetracycline. 15,67,68 For children under 8 years of age and those with tetracycline allergies, alternative oral antibiotic agents, including erythromycin, azithromycin, and trimethoprim/sulfamethoxazole, should be used very judiciously because of the potential risk for severe adverse reactions, such as toxic epidermal necrolysi. [69][70][71][72] Table 5 summarizes the dosages, adverse events, and precautions regarding the use of the most frequently used oral antibiotics for treatment of inflammatory acne.…”

Section: Oral Antibioticsmentioning

confidence: 99%

Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne

et al. 2013

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INTRODUCTION: Acne vulgaris is one of the most common skin conditions in children and adolescents. The presentation, differential diagnosis, and association of acne with systemic pathology differs by age of presentation. Current acknowledged guidelines for the diagnosis and management of pediatric acne are lacking, and there are variations in management across the spectrum of primary and specialty care. The American Acne and Rosacea Society convened a panel of pediatric dermatologists, pediatricians, and dermatologists with expertise in acne to develop recommendations for the management of pediatric acne and evidence-based treatment algorithms. METHODS: Ten major topic areas in the diagnosis and treatment of pediatric acne were identified. A thorough literature search was performed and articles identified, reviewed, and assessed for evidence grading. Each topic area was assigned to 2 expert reviewers who developed and presented summaries and recommendations for critique and editing. Furthermore, the Strength of Recommendation Taxonomy, including ratings for the strength of recommendation for a body of evidence, was used throughout for the consensus recommendations for the evaluation and management of pediatric acne. Practical evidence-based treatment algorithms also were developed. RESULTS: Recommendations were put forth regarding the classification, diagnosis, evaluation, and management of pediatric acne, based on age and pubertal status. Treatment considerations include the use of over-the-counter products, topical benzoyl peroxide, topical retinoids, topical antibiotics, oral antibiotics, hormonal therapy, and isotretinoin. Simplified treatment algorithms and recommendations are presented in detail for adolescent, preadolescent, infantile, and neonatal acne. Other considerations, including psychosocial effects of acne, adherence to treatment regimens, and the role of diet and acne, also are discussed. CONCLUSIONS: These expert recommendations by the American Acne and Rosacea Society as reviewed and endorsed by the American Academy of Pediatrics constitute the first detailed, evidence-based clinical guidelines for the management of pediatric acne including issues of special concern when treating pediatric patients.

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“…In a study the antimicrobial activity of minocycline was found to be greater than doxycycline and tetracycline in vivo [34] whereas in comparison to chlorhexidine weaker effects were reported [35]. Oliveira and coworkers performed in vitro minocycline activity on superinfecting microorganisms isolated from chronic periodontitis patients and the minimum inhibitory concentration (MIC) of microorganisms were found in the range as: Enterobacteriaceae (4-16 μg/ml), strains of Staphylococcus spp.…”

Section: Characteristics Of Minocycline Hclmentioning

confidence: 93%

Local Delivery of Minocycline Hydrochloride: A Therapeutic Paradigm in Periodontal Diseases

Javed¹,

Kohli

2010

CDD

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From the literature we can draw conclusions regarding the local use of minocycline in periodontal diseases. This review article attempts to evaluate the role of local delivery of minocycline HCl in the management of periodontal diseases. The efficacies of several local delivery devices of minocycline like minocycline films, strips, gels/ointment, microspheres and nanoparticles are discussed. The functional characteristics of local delivery devices of minocycline, their effectiveness as monotherapy, and comparison with scaling and root planning (SRP) are discussed in detail. Methods for the analysis of minocycline in various biological fluids, clinical trials and patents relevant to the local use of minocycline HCl in dental diseases have also been addressed in the article, conceptualizing the fact that direct application of minocycline into the diseased periodontal sulcus is an attractive treatment approach.

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The antimicrobial effects in vivo of minocycline, doxycycline and tetracycline in humans

Cited by 32 publications

References 5 publications

A pilot study on bacterial viability in acne. Assessment using dual flow cytometry on microbials present in follicular casts and comedones

A pilot study on bacterial viability in acne. Assessment using dual flow cytometry on microbials present in follicular casts and comedones

Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne

Local Delivery of Minocycline Hydrochloride: A Therapeutic Paradigm in Periodontal Diseases

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