The antimicrobial effects of ketamine combined with propofol: An in vitro study

Begeç, Zekine; Yücel, Aytaç; Yakupoğulları, Yusuf; Erdoğan, Mehmet Ali; Duman, Yücel; Durmuş, Mahmut; Ersoy, M. Özcan

doi:10.1016/j.bjane.2012.09.004

Cited by 25 publications

(30 citation statements)

References 12 publications

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“…MBCs were expressed as the concentration of the dicephalic surfactant that reduced the number of colony forming units by 99·9% after 24 h of incubation at 37°C, as described elsewhere (Begec et al . ).…”

Section: Methodsmentioning

confidence: 97%

Biofilm prevention by dicephalic cationic surfactants and their interactions with DNA

et al. 2016

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Section: Methodsmentioning

confidence: 97%

Biofilm prevention by dicephalic cationic surfactants and their interactions with DNA

et al. 2016

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“…To determine the minimal bactericidal concentration (MBC) 100 ll of bacterial suspension incubated with gemini QAS at the MIC, 2 9 MIC and 4 9 MIC was transferred to Luria Broth (1 % tryptone, 1 % yeast extract, 0.5 % NaCl) plate. MBC were expressed as the concentration of the gemini surfactant that reduced the number of colony forming units (cfu) by 99.9 % after 24 h of incubation at 37°C, as described elsewhere [18].…”

Section: Evaluation Of Minimal Inhibitory Concentration (Mic) and Minmentioning

confidence: 99%

Antibacterial Activity of Alanine‐Derived Gemini Quaternary Ammonium Compounds

Piecuch

Obłąk

Guz-Regner

2015

J Surfact & Detergents

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The antibacterial activity of alanine-derived gemini quaternary ammonium salts (chlorides and bromides) with various spacer and alkyl chain lengths was investigated. The studied compounds exhibited a strong bactericidal effect, especially bromides with 10 and 12 carbon alkyl chains and 3 carbon spacer groups (TMPAL-10 Br and TMPAL-12 Br), with a short contact time. Both salts dislodged biofilms of Pseudomonas aeruginosa and Staphylococcus epidermidis, and were lethal to adherent cells of S. epidermidis. Bromide with 2 carbon spacer groups and 12 carbon alkyl chains (TMEAL-12 Br) effectively reduced microbial adhesion by coating polystyrene and silicone surfaces. The results obtained suggest that, after further studies, gemini QAS might be considered as antimicrobial agents in medicine or industry.

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“…Ketamine has been shown to exert antibacterial and antifungal activity 50 and, considering that it is also pharmaceutically compatible with propofol, 51 it may be argued that propofolketamine mixtures may reduce the risk of infection due to extrinsic contamination. Begec et al 50 studied the growth rates of several micro-organisms and the minimal bactericidal concentrations of ketamine in mixtures with 1% propofol (without EDTA).…”

Section: Discussionmentioning

confidence: 99%

“…Begec et al 50 studied the growth rates of several micro-organisms and the minimal bactericidal concentrations of ketamine in mixtures with 1% propofol (without EDTA). Ketamine retained microbial activity for certain organisms, but at different concentrations.…”

Section: Discussionmentioning

confidence: 99%

A survey of propofol injection practices reveals poor knowledge of and unsatisfactory adherence to the SASA Guidelines for Infection Control

Breedt

Coetzee

Kluyts

et al. 2017

Southern African Journal of Anaesthesia and Analgesia

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Background: Propofol lipid emulsion supports bacterial growth and various outbreaks of postoperative infection are attributed to extrinsic contamination. This study's objectives were to ascertain propofol administration practices among South African anaesthesiologists and to determine the influence of the 2014 South African Society of Anaesthesiologists (SASA) Guidelines for Infection Control in Anaesthesia. Methods: A total of 1 598 SASA members were invited to participate anonymously and 634 replies were received. Using a riskscoring system developed from 13 questionnaire items, 542 respondents who administer propofol infusions were stratified into Low-, Moderate-, High-and Very High-Risk groups. Results: The majority (65%) of the 542 participants who administer propofol infusions were classified as Moderate Risk, 29% as Low Risk and 6% as High and Very High Risk. Some 61% were aware of the SASA Guidelines, of whom 47.3% had studied them. The median risk-score of the Studied Guidelines group was significantly smaller (p < 0.001). They included a greater proportion who were categorised as low risk (58% vs. 45%) and a lower proportion who were moderate risk (38% vs. 51%). Proportions of high-risk individuals did not differ. Of the total 634 respondents, 247 used rubber-stoppered vials of whom 28% had studied the SASA Guidelines; 20% of the Studied Guidelines group often/always shared vial contents between patients versus 12% of those who had not studied them (p = 0.13). Conversely, 40% (studied group) versus 13.6% (not-studied group) often/always wiped the diaphragm and seldom/never shared vial contents between patients (p < 0.0001). In all, 25% of the total 634 respondents often/ always pre-prepared multiple propofol syringes; 5.0% diluted propofol and often/always pre-prepared syringes. Conclusion: Penetration of the SASA Guidelines was low. Differences in unsafe practices among anaesthesiologists who had read the guidelines were statistically significant but clinically inconsequential. This highlights a need for greater publicity, emphasising their practical importance.

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The antimicrobial effects of ketamine combined with propofol: An in vitro study

Cited by 25 publications

References 12 publications

Biofilm prevention by dicephalic cationic surfactants and their interactions with DNA

Biofilm prevention by dicephalic cationic surfactants and their interactions with DNA

Antibacterial Activity of Alanine‐Derived Gemini Quaternary Ammonium Compounds

A survey of propofol injection practices reveals poor knowledge of and unsatisfactory adherence to the SASA Guidelines for Infection Control

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