The antimicrobial spectrum of Xeroform ®

Barillo, David J.; Barillo, Anthony R.; Korn, Sarah; Lam, Kei Fong; Attar, Paul

doi:10.1016/j.burns.2016.10.023

Cited by 35 publications

(32 citation statements)

References 25 publications

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“…All the platinum complexes (16)(17)(18)(19)(20) were generally active against MRSA and the two tested fungal strains. The platinumcyclooctadiene type complexes have been studied mainly as precursors, e.g.…”

Section: 5%mentioning

confidence: 99%

“…[16][17][18] Xeroform, namely tribromophenatebismuth(III), is used as an antimicrobial in wound dressing applications. 19 A bismuth-thiol compound (pravibismane) just completed a phase 1b clinical trial for the treatment of infected diabetic foot ulcers. 20 Silver is also used in a variety of forms for the treatment of wounds and management of infections.…”

Section: Introductionmentioning

confidence: 99%

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Metal complexes as a promising source for new antibiotics

et al. 2020

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Section: 5%mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metal complexes as a promising source for new antibiotics

et al. 2020

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“…If the patient is less than 1 year old, vaseline gauze should be used due to its nontoxic and nonirritable properties for this age group. 8 Vaseline, rather than Xeroform, is recommended for patients under the age of 1 year since 3% bismuth tribromophenate has been associated with bacteriostatic properties, 9 possibly related to a delay in growth and microbiome alteration in babies under the age of 1 year. 10,11 Bacitracin can also be used in cases where contamination is a risk factor, but simple Vaseline in many cases is enough and could also prevent antibiotic resistance.…”

Section: Hand and Upper-extremity Burn Managementmentioning

confidence: 99%

Practical Management of Common Skin Injuries, Lacerations, Wounds, Trigger Fingers, and Burns

Akiki

Mehrzad

2020

J Am Board Fam Med

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Primary care clinicians encounter many conditions during their day-today visits with patients. A few of these common presentations include burns, lacerations, trauma to the hand, and wounds, some of which do not require an evaluation by a specialist and can be managed outpatient by primary care clinicians. In this article, we share evidence-based tips to avoid common pitfalls in primary care recognition and management of such presentations as well as guide them to manage many of these conditions themselves. We also provide guidance in the decision to refer the patient to a plastic surgeon or other specialists.

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Section: Scopementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metal Complexes as a Promising Source for New Antibiotics

Frei

Zuegg²,

Elliott³

et al. 2019

Preprint

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There is a dire need for new classes of antimicrobial compounds to combat the growing threat of widespread antibiotic resistance. With a currently very scarce drug pipeline, consisting mostly of derivatives of known antibiotics, new classes of antibiotics are urgently required. Antibiotic compounds are notorious for not having very “drug-like” chemical structures. Metal complexes are currently in clinical development for the treatment of cancer, malaria and neurodegenerative diseases. However, only little attention has been paid to their application as potential antimicrobial compounds. We report the evaluation of 906 metal-containing compounds that have been screened by the Community for Open Antimicrobial Drug Discovery (CO-ADD) for antimicrobial activity. Metal-bearing compounds display a significantly higher hit-rate (9.9%) when compared to the purely organic molecules (0.87%) in the CO-ADD database. Out of 906 compounds, 88 show activity against at least one of the tested strains, including fungi, while not displaying any cytotoxicity against mammalian cell lines or haemolytic properties. Herein, we highlight the structures of the 30 compounds with activity against Gram-positive and/or Gram-negative bacteria containing Mn, Co, Zn, Ru, Ag, Eu, Ir and Pt, with activities down to the nanomolar range against methicillin resistant <i>S. aureus </i>(MRSA). This work reveals the vast diversity that metal-containing compounds can bring to antimicrobial research. It is important to raise awareness of these types of compounds for the design of truly novel antibiotics with potential for combatting antimicrobial resistance.

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The antimicrobial spectrum of Xeroform ®

Cited by 35 publications

References 25 publications

Metal complexes as a promising source for new antibiotics

Metal complexes as a promising source for new antibiotics

Practical Management of Common Skin Injuries, Lacerations, Wounds, Trigger Fingers, and Burns

Metal Complexes as a Promising Source for New Antibiotics

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