The antinatriuretic action of biosynthetic human growth hormone in man involves activation of the renin-angiotensin system

K, Ho; Weissberger, Andrew J.

doi:10.1016/0026-0495(90)90065-k

Cited by 159 publications

(94 citation statements)

References 31 publications

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“…Our study showed that the serum Na concentration was higher in HT than in NT, and significantly correlated with blood pressure. In this regard, we then studied the role of the renin-aldosterone system, because it was reported that there were low renin activity and a high aldosterone concentration in acromegaly [5,7,16,17] and that GH activates the renin-aldosterone system [10]. But we found that neither PRA nor the serum aldosterone concentration was increased significantly in HT.…”

Section: Discussionmentioning

confidence: 94%

“…Many investigators have reported that an increase in extracellular fluid and retention of Na exist in acromegaly [7][8][9][10][11][12][13][14][15], and these were thought to contribute to hypertension. In addition, the increase in extracellular fluid was reduced after treatment of the disease [9].…”

Section: Discussionmentioning

confidence: 99%

“…Quite interestingly, a high incidence of hypertension has been noticed in patients with acromegaly [2][3][4][5][6]. It has been reported that plasma volume and serum Na are increased in acromegaly [7][8][9][10][11][12][13][14][15], and these are able to induce hypertension.…”

Section: Introductionmentioning

confidence: 99%

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Hypertension in Acromegaly: Hereditary Hypertensive Factor Produces Hypertension by Enhancing IGF-I Production.

Ohtsuka

Komiya²,

Aizawa

et al. 1995

Endocr J

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Abstract.Sixty-four patients with acromegaly were retrospectively analyzed to study the incidence and cause of hypertension in acromegaly. WHO criteria indicate that 37.5% patients with acromegaly have hypertension.The blood pressure was positively correlated with age, the insulin-like growth factor I (IGF-I) and serum sodium (Na) concentration.In addition, IGF-I and Na were significantly different in hypertensive and normotensive groups. Seventy-five percent of hypertensive patients had a family history of hypertension.IGF-I, Na and blood pressure were significantly higher in patients with a family history of hypertension than in those without it. In patients with a family history of hypertension, blood pressure was positively correlated with IGF-I and serum Na, but IGF-I was not correlated with serum Na. In patients without such a family history, blood pressure had a good correlation only with age, and IGF-I was not significantly correlated with blood pressure. In addition, the incidence of hypertension in this group was the same as or lower than that in the general population.The above results suggest that the genetic factor produces hypertension in acromegaly by two ways, by increasing Na and enhancing IGF-I production by GH.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hypertension in Acromegaly: Hereditary Hypertensive Factor Produces Hypertension by Enhancing IGF-I Production.

Ohtsuka

Komiya²,

Aizawa

et al. 1995

Endocr J

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“…insulin sensitivity) may be implicated in increasing ECW volume. Probably, the initial administration of rhGH in GHD adults results in an acute activation of the reninangiotensin system [30]. After some delay, counteraction of the regulatory mechanism in fluid balance take place.…”

Section: Discussionmentioning

confidence: 99%

Direct assessment of extracellular water volume by the bromide‐dilution method in growth hormone‐deficient adults*

Snel¹,

Brummer

Bol

et al. 1995

Eur J Clin Investigation

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Abstract. Body composition and water content were assessed in 36 growth hormone deficient (GHD) patients (M:23, F:13) and 14 controls (M:7, F:7) using anthropometry, hydrodensitometry, bioelectrical impedance measurement and the bromide-dilution method, with which extracellular water volume can be measured directly. GHD patients, compared to controls, did not differ in extracellular water volume, in hydration state and water distribution. A higher BMI (P= 0.002) and a higher body fat mass ( P < 0.0001) were found in the patients. Based on circumference measurements, the GHD patients had a higher waist/ hip ratio (P = 0.0001). This study shows that GHD patients, in comparison with healthy controls, have a normal extracellular water volume. The finding that extracellular water volume is within the normal range in GHD patients may be clinically relevant as it is well known that in the first months after initiating GHreplacement therapy, most patients have signs and symptoms of excessive water retention.

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“…The reports of IH in children with severe GH insensitivity (Laron syndrome) and children with low insulin-like growth factor 1 (IGF-1) treated with recombinant IGF-1 (19,20) suggest that exposure to IGF-1 may be the pathophysiologic mediator of the rhGH effect. Increased cerebrospinal fl uid (CSF) production, decreased CSF absorption, changes in CSF fl ow, or a combination of these factors have been postulated (21,22) . From NCGS data, IGHD and OGHD with maximum stimulated GH ≥ 5 ng/mL as well as ISS patients appear to have the lowest risk of IH, whereas severe IGHD and OGHD (maximum stimulated GH < 5 ng/mL) patients are at greater risk.…”

Section: Discussionmentioning

confidence: 99%

Intracranial hypertension in pediatric patients treated with recombinant human growth hormone: data from 25 years of the Genentech National Cooperative Growth Study

Noto¹,

Maneatis²,

Frane³

et al. 2011

Journal of Pediatric Endocrinology and Metabolism

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Intracranial hypertension (IH) is a rare condition in children. However, a relationship between recombinant human growth hormone (rhGH) therapy and IH has been well documented. Risk factors were assessed for 70 rhGH-naive patients enrolled in the National Cooperative Growth Study with reports of IH after treatment initiation. Patients with severe growth hormone defi ciency, Turner syndrome, chronic renal insuffi ciency (CRI), and obesity (particularly in the CRI group) were at highest risk of developing IH during the fi rst year of therapy, suggesting initiation of careful early monitoring. In some patients, factors such as corticosteroid use or other chromosomal abnormalities appear to confer a delayed risk of IH, and these patients should be monitored long-term for signs and symptoms of IH.

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The antinatriuretic action of biosynthetic human growth hormone in man involves activation of the renin-angiotensin system

Cited by 159 publications

References 31 publications

Hypertension in Acromegaly: Hereditary Hypertensive Factor Produces Hypertension by Enhancing IGF-I Production.

Hypertension in Acromegaly: Hereditary Hypertensive Factor Produces Hypertension by Enhancing IGF-I Production.

Direct assessment of extracellular water volume by the bromide‐dilution method in growth hormone‐deficient adults*

Intracranial hypertension in pediatric patients treated with recombinant human growth hormone: data from 25 years of the Genentech National Cooperative Growth Study

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