The antinociceptive effect of acetylsalicylic acid is differently affected by a CB1 agonist or antagonist and involves the serotonergic system in rats

Ruggieri, Valentina; Vitale, Giovanni; Filaferro, Monica; Frigeri, Claudio; Pini, Luigi Alberto; Sandrini, Maurizio

doi:10.1016/j.lfs.2010.02.006

Cited by 9 publications

(10 citation statements)

References 41 publications

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“…Several studies showed that the Nitroglycerin induces hyperalgesia in rats in the same manner but on different animal species and weight (Sprague-Dawley rats, weight 180–200 mg) [ 34 , 35 ]. Ruggieri et al introduced an experimental model of hot-plate induced nociception and on formalin test induced hyperalgesia on Wistar rats that can be used for testing the efficiency of different compounds on nociception pathophysiological mechanisms [ 36 ]. One of the possible mechanisms associated with hyperalgesia after NTG administration consists in central sensitization induced by NO released from NTG.…”

Section: Discussionmentioning

confidence: 99%

Preemptive Analgesic and Antioxidative Effect of Curcumin for Experimental Migraine

Bulboacă

Bolboacă

Stănescu

et al. 2017

BioMed Research International

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Objective Our study aimed to investigate the analgesic and antioxidative stress effects of Curcumin (CC) in experimental migraine induced by Nitroglycerin (NTG) on rats, compared with Indomethacin (ID) and Propranolol (PP) treatments. Material and Methods Five groups of 10 rats treated i.p. were investigated: control group (healthy rats) injected with saline solution (0.9%), NTG-control group injected with NTG (1 mg/100 gbw, bw = body weight), and three groups with pretreatment applied 30 min previous to the formalin test (NTG + CC group: Curcumin (10 mg/100 gbw), NTG + PP group: Propranolol (100 μg/100 gbw), and NTG + ID group: Indomethacin (0.5 mg/100 gbw)). Formalin test was performed and number of flinches and shakes were counted. Several oxidative stress parameters were also assessed. Results The smallest values of malondialdehyde (MDA), nitric oxide (NOx), and total oxidative status (TOS) were observed on NTG + CC with significant differences as compared with the control group (p < 0.0001). The group pretreated with Curcumin proved significantly smaller number of flinches and shakes compared with both NTG + PP and NTG + ID. Conclusion Our study demonstrates a superior activity of Curcumin not only versus control, but also versus Propranolol and Indomethacin.

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Section: Discussionmentioning

confidence: 99%

Preemptive Analgesic and Antioxidative Effect of Curcumin for Experimental Migraine

Bulboacă

Bolboacă

Stănescu

et al. 2017

BioMed Research International

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“…The aspirin solution was freshly prepared before use. The dose of aspirin used in the present experiments was 100 mg/kg body weight according to its antinociceptive effect [10]. Acetaminophen (paracetamol) was purchased from T.P.…”

Section: Methodsmentioning

confidence: 99%

“…The volume of all drug injections was calculated according to standard criteria (intraperitoneally 10 mL/kg) [12]. Doses of analgesics were chosen based on the presence of efficacy without serious adverse effects [6–8, 10, 11]. Intraperitoneal injections of the calculated dose or vehicle control were made daily from 8:00 to 9:00 am .…”

Section: Methodsmentioning

confidence: 99%

Neural hyperactivity in the amygdala induced by chronic treatment of rats with analgesics may elucidate the mechanisms underlying psychiatric comorbidities associated with medication-overuse headache

2017

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BackgroundPatients with medication-overuse headache suffer not only from chronic headache, but often from psychiatric comorbidities, such as anxiety and depression. The mechanisms underlying these comorbidities are unclear, but the amygdala is likely to be involved in their pathogenesis. To investigate the mechanisms underlying the comorbidities we used elevated plus maze and open field tests to assess anxiety-like behavior in rats chronically treated with analgesics. We measured the electrical properties of neurons in the amygdala, and examined the cortical spreading depression (CSD)-evoked expression of Fos in the trigeminal nucleus caudalis (TNC) and amygdala of rats chronically treated with analgesics. CSD, an analog of aura, evokes Fos expression in the TNC of rodents suggesting trigeminal nociception, considered to be a model of migraine.ResultsIncreased anxiety-like behavior was seen both in elevated plus maze and open field tests in a model of medication overuse produced in male rats by chronic treatment with aspirin or acetaminophen. The time spent in the open arms of the maze by aspirin- or acetaminophen-treated rats (53 ± 36.1 and 37 ± 29.5 s, respectively) was significantly shorter than that spent by saline-treated vehicle control rats (138 ± 22.6 s, P < 0.001). Chronic treatment with the analgesics increased the excitability of neurons in the central nucleus of the amygdala as indicated by their more negative threshold for action potential generation (–54.6 ± 5.01 mV for aspirin-treated, –55.2 ± 0.97 mV for acetaminophen-treated, and –31.50 ± 5.34 mV for saline-treated rats, P < 0.001). Chronic treatment with analgesics increased the CSD-evoked expression of Fos in the TNC and amygdala [18 ± 10.2 Fos-immunoreactive (IR) neurons per slide in the amygdala of rats treated with aspirin, 11 ± 5.4 IR neurons per slide in rats treated with acetaminophen, and 4 ± 3.7 IR neurons per slide in saline-treated control rats, P < 0.001].ConclusionsChronic treatment with analgesics can increase the excitability of neurons in the amygdala, which could underlie the anxiety seen in patients with medication-overuse headache.Electronic supplementary materialThe online version of this article (doi:10.1186/s12868-016-0326-z) contains supplementary material, which is available to authorized users.

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“…Diante dos resultados anteriormente discutidos no modelo de nocicepção térmica, mostrando o efeito central do WIN55,212-2, bem como do HU-474 na placa quente, era de se esperar que o antagonista dos receptores CB1, pelo menos em parte atenuaria o efeito desses compostos, já que no modelo de contorção abdominal induzida por ácido acético, parte do processamento da nocicepção se dá por ação central, e este pode ser mediado por receptores canabinóides (Ruggieri et al, 2010;Malan et al, 2001;Ulugol et al, 2006). Em outro trabalho, Smith e colaboradores (2000) observaram que animais desafiados com lipopolissacarídeo (LPS), tiveram uma diminuição sérica de TNF-α, após o tratamento com os agonistas canabinóides WIN55212-2 e HU-210.…”

Section: Experimento 14: Efeitounclassified

“…Em um trabalho utilizando o canabinóide sintético HU-210, um agonista dos receptores CB1, mostrou que este composto possui efeito antinociceptivo no teste da placa quente. Sendo que, esses efeitos também foram revertidos pela prévia administração do antagonista CB1, SR141716A(Ruggieri et al, 2010).…”

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Comparação dos efeitos farmacológicos do canabidiol e seu análogo sintético HU-474

Silva¹

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The antinociceptive effect of acetylsalicylic acid is differently affected by a CB1 agonist or antagonist and involves the serotonergic system in rats

Cited by 9 publications

References 41 publications

Preemptive Analgesic and Antioxidative Effect of Curcumin for Experimental Migraine

Preemptive Analgesic and Antioxidative Effect of Curcumin for Experimental Migraine

Neural hyperactivity in the amygdala induced by chronic treatment of rats with analgesics may elucidate the mechanisms underlying psychiatric comorbidities associated with medication-overuse headache

Comparação dos efeitos farmacológicos do canabidiol e seu análogo sintético HU-474

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