The Antioxidant and Anti-Inflammatory Effects of Quercus brantii Extract on TNBS-Induced Ulcerative Colitis in Rats

Naini, Mahvash Alizade; Mehrvarzi, Shayan; Zargari-Samadnejadi, Asal; Tanideh, Nader; Ghorbani, Mohammad; Dehghanian, Amirreza; Hasanzarrini, Maryam; Banaee, Farnaz; Koohi-Hosseinabadi, Omid; Irajie, Cambyz; Iraji, Aida

doi:10.1155/2021/3075973

Cited by 8 publications

(8 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The licorice root (voucher number: MPH-2670-1) was dried and ground. Then, the powder was incubated in a percolator using 500 mL of ethanol 70% for 72 h. The extra solution was vaporized by the rotary to concentrate the extract and kept at −20 °C until use [ 46 , 47 ].…”

Section: Methodsmentioning

confidence: 99%

Hydroalcoholic extract of Glycyrrhiza glabra root combined with Linum usitatissimum oil as an alternative for hormone replacement therapy in ovariectomized rats

Tanideh¹,

Daneshmand²,

Karimimanesh³

et al. 2023

Heliyon

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

Hydroalcoholic extract of Glycyrrhiza glabra root combined with Linum usitatissimum oil as an alternative for hormone replacement therapy in ovariectomized rats

Tanideh¹,

Daneshmand²,

Karimimanesh³

et al. 2023

Heliyon

View full text Add to dashboard Cite

“…In the case of 10% v/v solution, 10 ml of this solution was added to 90 ml of 2% CMC solution (volume final = 100 ml). The mixtures were gradually stirred for 1 h and a uniform gel was obtained, collected in an aluminium tube and stored in the refrigerator (Alizade Naini et al., 2021 ; Naini et al., 2021 ). In each treatment, 0.5 ml of gel was applied daily to the wound site using a dropper to fully cover the wound site.…”

Section: Methodsmentioning

confidence: 99%

Wound healing effect of Carum carvi L. on the incised skin wound in male rats: Histopathology, total protein and biomechanical evaluations

Rafsanjani

Naeini

Meimandi-Parizi

et al. 2022

Veterinary Medicine & Sci

Self Cite

View full text Add to dashboard Cite

Background The skin has several functions, one of the most important of which is to protect the internal organs from external damage and the entry of germs. Since skin and wound healing is one of the mostly concerned issues worldwide, the development of wound healing remedies is one of the main fields in modern medical research. Objectives To evaluate the effect of the hydroalcoholic extract of Cumin carvi L. seed as one of the traditional medicinal plants used for wound healing through an in vivo model. Methods Wide circular skin wounds (2 × 2 cm) were created on the dorsal area of 50 Sprague–Dawley male rats following ethical principles. The animals were divided into five groups including no treatment, base gel, tetracycline treatment, 10% v/v hydroalcoholic extract of Cumin carvi L. seed treatment and 20% v/v hydroalcoholic extract of Cumin carvi L. seed treatment group. Treatment was performed within 20 days. On days 1, 3, 5, 7 and 10, photographs were taken, and the percentage of wound healing was calculated. Also, on the 10th day, the skin area was sampled for histopathology and on the 20th day, the skin was sampled for biomechanical and total protein assessments. Results The results of wound healing percentage showed that from day 3 onwards, there was a significant improvement between the group treated with 20% v/v hydroalcoholic extract of Cumin carvi L. and the negative control and basal gel groups (p < 0.05). According to histopathological and total protein content evaluations, the amount of collagen production and inflammation score in the Cumin carvi‐treated groups confirmed the healing process compared to other groups. Conclusions According to the results of this project, 20% v/v ethanolic extract of Cumin carvi L. has potential therapeutic effects in the treatment of skin wounds. Wounds are one of the health concerns, and the economic burden of wound care and healing has continued to increase over the past years. The healing effects of C. carvi. ethanolic extract on the wound were investigated. The histopathological and macroscopical evaluations, as well as total protein content, were measured to investigate its wound healing properties.

show abstract

“…The gel was homogenized for 30 minutes, and the gel was collected in an aluminum tube in the refrigerator. For rectal administration, the gavage needle was inserted into the anus of rats (7 cm) and 1 ml of the prepared gel was injected [ 40 ].…”

Section: Methodsmentioning

confidence: 99%

Anti-Inflammatory, Antioxidant, and Healing-Promoting Effects of Aloe vera Extract in the Experimental Colitis in Rats

Naini

Zargari-Samadnejad

Mehrvarz

et al. 2021

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

Background. Ulcerative colitis is a worldwide chronic gastrointestinal disease characterized by variable extensions of colon mucosal inflammation. The available drugs have an incomplete response with various side effects and socioeconomic impacts. Aloe barbadensis Miller (Aloe vera) is a well-known medicinal plant with diverse pharmacological and therapeutic activities. As a result, in the current study, Aloe vera was selected to evaluate its therapeutic effects on experimental colitis in rats. Methods. This study is intended to evaluate the possible beneficial effect of Aloe vera for the treatment of experimental colitis. Trinitrobenzenesulfonic acid (TNBS) was used to induce experimental colitis in 60 of 70 Wistar rats. The rats were grouped in 7 clusters including healthy control, negative, positive control (received sulfasalazine), and test groups treated with Aloe vera extracts via oral or rectal routes. Macroscopic and histologic factors as well as the biochemical parameters were evaluated on day 7. Results. In the present study, it was found that serum levels of tumor necrosis factor-α (75 vs. 44 pg./ml), interleukin-6 (41 vs. 21 pg/ml), and nitric oxide (24 vs. 6 μm/ml) in TNBS-induced untreated colitis treatment were significantly increased as compared to healthy control. Similar patterns were also observed in malondialdehyde (76.41 vs. 236.35 μg/mg) and myeloperoxidase (4.24 vs. 29.38 U/mg) in colonic tissue. Among different treatments, rectal administration of Aloe vera extract (400 mg/kg) exhibited the best result in which serum concentration of tumor necrosis factor-α (55 pg/ml), interleukin-6 (24 pg/ml), and nitric oxide (10 μm/ml) and the levels of malondialdehyde (102.67 μg/mg), as well as myeloperoxidase (12.29 U/mg) in colon tissue, were reduced as compared to the untreated group. Also, the body weight and colon weight/length ratios were more improved in the treated group with 400 mg/kg Aloe vera extract, rectally. Conclusion. Aloe vera extract exhibited a therapeutic effect in TNBS-induced colitis, and local, rectal administration of Aloe vera extract was more effective than oral administration.

show abstract

The Antioxidant and Anti-Inflammatory Effects of Quercus brantii Extract on TNBS-Induced Ulcerative Colitis in Rats

Cited by 8 publications

References 63 publications

Hydroalcoholic extract of Glycyrrhiza glabra root combined with Linum usitatissimum oil as an alternative for hormone replacement therapy in ovariectomized rats

Hydroalcoholic extract of Glycyrrhiza glabra root combined with Linum usitatissimum oil as an alternative for hormone replacement therapy in ovariectomized rats

Wound healing effect of Carum carvi L. on the incised skin wound in male rats: Histopathology, total protein and biomechanical evaluations

Anti-Inflammatory, Antioxidant, and Healing-Promoting Effects of Aloe vera Extract in the Experimental Colitis in Rats

Contact Info

Product

Resources

About