The antioxidant and antidiabetic potentials of polyphenolic-rich extracts of<i>Cyperus rotundus</i>(Linn.)

Mohamed, Almahi I.; Beseni, Brian K.; Msomi, Nontokozo Z.; Salau, Veronica F.; Erukainure, Ochuko L.; Aljoundi, Aimen; Islam, Md. Shahidul

doi:10.1080/07391102.2021.1967197

Cited by 12 publications

(9 citation statements)

References 56 publications

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“…However, this experiment only studied the antioxidant and free radical scavenging activities of total oligomeric flavonoid fraction of CR in vitro, lacking intracellular and in vivo studies. Mohamed et al (2021) also proved that Xiangfu has antioxidant effect. Kilani et al (2005) Thus, the volatile oil of CR has very good oxidation resistance (Hao).…”

Section: Anti-oxidationmentioning

confidence: 88%

“…The binding energy of 4-methyl-2-(2,4,4-trimethylpentane-2-yl) phenol was the lowest, and its affinity with the active site of glucosidase was the best. These results suggest that CR may have antioxidant and anti-diabetic effects (Mohamed et al, 2021). Luo et al was used to study the effects of TOF fraction of CR on blood glucose, blood lipid and antioxidant activity of diabetic rats by using a diabetic rat model with high fat and high sugar diet and intraperitoneal injection of streptozotocin.…”

Section: Hypoglycemicmentioning

confidence: 99%

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Systematic review of ethnomedicine, phytochemistry, and pharmacology of Cyperi Rhizoma

Wang

Zhang²,

Zhang³

et al. 2022

Front. Pharmacol.

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Cyperi Rhizoma (CR) is the dry rhizome of Cyperus rotundus L., a Cyperaceae plant. It has a long history of clinical medication and is known as the “holy medicine” of gynecology. CR smells sweet and bitter. It has the effect of soothing the liver and relieving depression, regulating qi, regulating meridian and relieving pain. It can be used to treat liver qi stagnation, chest pain, spleen and stomach qi stagnation, hernia pain, irregular menstruation and other diseases. At present, the main chemical constituents isolated from CR are volatile oil, flavonoids and terpenes. Modern pharmacological studies have shown that CR has a wide range of pharmacological activities, including antidepressant, hypoglycemic, antioxidant, anti-inflammatory, antipyretic and analgesic effects. In this paper, the botany, traditional application, phytochemistry, pharmacological effects, processing and other aspects of CR are reviewed. At the same time, the shortcomings of current research of CR are discussed in depth, and the possible solutions are put forward in order to find a breakthrough point for future research of CR.

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Section: Anti-oxidationmentioning

confidence: 88%

Section: Hypoglycemicmentioning

confidence: 99%

Systematic review of ethnomedicine, phytochemistry, and pharmacology of Cyperi Rhizoma

Wang

Zhang²,

Zhang³

et al. 2022

Front. Pharmacol.

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“…The current study evaluated the protective roles of Stevia against the toxicity induced by Tartrazine in male rats. The GC‐MS characterization of the ASE explained its higher antioxidant activity as a result of the existence of high amounts of polyphenols, organic acids, and some antioxidants such as 4‐methyldaphnetin, 31 trimethylsilyl‐di(trimethylsiloxy)‐silane, 37 cis‐4‐trimethylsilyloxy cyclohexyl(trimethylsilyl)carboxylate, 34 2‐propenenitrile, 3‐phenyl‐, (E), 35 phenol, 2‐methyl‐4‐(1,1,3,3‐tetramethyl butyl), 36 glycerol monostearate, 2TMS derivative, 37 and other compounds that may have antioxidant activity that play an important role in improving male rat fertility.…”

Section: Discussionmentioning

confidence: 99%

“…methyl-4-(1,1,3,3-tetramethyl butyl),36 glycerol monostearate, F I G U R E 5 Histological examination of the kidney. Stevia group (B), Tartrazine group (C), and Tartrazine and Stevia-treated group (D) compared with the control group (A).…”

mentioning

confidence: 99%

The protective effect of aqueous extract ofStevia rebaudianaagainst tartrazine toxicity in male Wistar rat

Hanna,

Beshay,

El. Shafee

et al. 2023

Cell Biochemistry & Function

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Tartrazine is a yellow colouring agent that is commonly used in foods; however, high dosages of Tartrazine affect fertility and create oxidative stress by generating free radicals. A plant species known as Stevia rebaudiana has natural antioxidants that show promise for protecting testicular tissue. Consequently, this study was intended to examine the ameliorative effect of the aqueous extract of S. rebaudiana (Stevia) on the fertility of male Wistar rats induced by the daily oral intake of Tartrazine. Utilizing gas chromatography–mass spectrometry, phytochemical identification was accomplished for Stevia extract. Study groups were separated into several groups: the first group (the control) got distilled water for up to 56 days; the Stevia group (1000 mg/kg), the Tartrazine group (300 mg/kg) and the Stevia and Tartrazine group (the group was given Tartrazine after 1 h of Stevia extract intake). Also, the oxidative damage in testicular tissues was assessed by measuring the levels of malondialdehyde (MDA) and antioxidants (catalase [CAT], superoxide dismutase [SOD] and glutathione reductase [GSH]). Further, histological alterations were examined. In addition, cyclic AMP‐responsive element modulator (Crem) gene expression levels and their relative proteins were measured in the testicular tissues using quantitative real‐time polymerase chain reaction and enzyme‐linked immunosorbent assays, respectively. Sperm analysis and testosterone concentration were also performed. SPSS version 25 was used for the analysis of results while (p < .05) was regarded as significant. Compared with the control group, the results demonstrated that Tartrazine caused a significant reduction (p < .05) in the testosterone hormone level (0.70 ± 0.21) and the Crem protein quantity (1.21 ± 0.23) in the treated Tartrazine group. Also, it had a significant decrease (p < .05) in sperm motility, viability, count and antioxidant levels. Moreover, there was a significant increase (p < .05) in sperm abnormalities, MDA level (7.40 ± 1.10), kidney and liver function parameters, and DNA degradation in the treated Tartrazine group compared with the control group. On the contrary, the Stevia extract intake enhanced the testosterone (2.50 ± 0.60), antioxidants and Crem protein levels (2.33 ± 0.10) with an improvement in sperm quality in the Stevia and Tartrazine‐treated group compared with the Tartrazine group. Stevia also caused a significant decrease (p < .05) in the MDA level (3.20 ± 0.20), and sperm abnormalities with an enhancement of the liver and kidney function parameters in the Stevia and Tartrazine‐treated group compared to the Tartrazine group. Stevia administration has a protective effect on the testicular tissues and sperm quality against toxicity induced by Tartrazine exposure, so it will be a good antioxidant drug to be administered daily before daily administration of Tartrazine.

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“…Hence, they play a significant role as alternative medications due to decreased side effects and low cost. The benefit of medicinal plants in treating T2D has been reported in several reports (Kavishankar, 2011;Mohamed et al, 2021).…”

Section: Importance Of Medicinal Plants In the Treatment And Manageme...mentioning

confidence: 84%

Antioxidative and antidiabetic activity and phytochemicals analysis of some selected Sudanese traditional medicinal plants.

Idris

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The antioxidant and antidiabetic potentials of polyphenolic-rich extracts ofCyperus rotundus(Linn.)

Cited by 12 publications

References 56 publications

Systematic review of ethnomedicine, phytochemistry, and pharmacology of Cyperi Rhizoma

Systematic review of ethnomedicine, phytochemistry, and pharmacology of Cyperi Rhizoma

The protective effect of aqueous extract ofStevia rebaudianaagainst tartrazine toxicity in male Wistar rat

Antioxidative and antidiabetic activity and phytochemicals analysis of some selected Sudanese traditional medicinal plants.

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