The antioxidant and immunomodulatory compound 3-[(4-chlorophenyl)selanyl]-1-methyl-1H-indole attenuates depression-like behavior and cognitive impairment developed in a mouse model of breast tumor

Casaril, Angela Maria; Domingues, Micaela; Bampi, Suely Ribeiro; Lourenço, Darling de Andrade; Smaniotto, Thiago Ângelo; Segatto, Natália Vieira; Vieira, Beatriz; Seixas, Fabiana Kömmling; Collares, Tiago; Lenardão, Eder J.; Savegnago, Lucielli

doi:10.1016/j.bbi.2019.12.005

Cited by 30 publications

(19 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some recent impressive examples can be summarized by 4-selenylquinoline 1 [ 5 ]; a powerful anti-inflammatory compound when compared to the worldwide marketized Meloxicam ® , and 3-selenylindole 2 [ 6 , 7 ], which has been demonstrating promising results against mood and neurodegenerative diseases; worthy of be mention are the DiSelenobisBenzAmides (DiSeBAs, 3 ) endowed with potent and broad anti-HIV activity [ 8 ] due to their ability to inhibit NCp7 [ 9 , 10 ] and Se-Quercetines ( 4 is the prototypical compound ( Figure 1 ), capable of blocking the replication of SARS-CoV-2 [ 11 ]. For this reason, different synthetic approaches to accessing organoselenium compounds are continuously advancing, with ingenious methodologies being constantly reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

“Green Is the Color”: An Update on Ecofriendly Aspects of Organoselenium Chemistry

et al. 2022

View full text Add to dashboard Cite

Organoselenium compounds have been successfully applied in biological, medicinal and material sciences, as well as a powerful tool for modern organic synthesis, attracting the attention of the scientific community. This great success is mainly due to the breaking of paradigm demonstrated by innumerous works, that the selenium compounds were toxic and would have a potential impact on the environment. In this update review, we highlight the relevance of these compounds in several fields of research as well as the possibility to synthesize them through more environmentally sustainable methodologies, involving catalytic processes, flow chemistry, electrosynthesis, as well as by the use of alternative energy sources, including mechanochemical, photochemistry, sonochemical and microwave irradiation.

show abstract

Section: Introductionmentioning

confidence: 99%

“Green Is the Color”: An Update on Ecofriendly Aspects of Organoselenium Chemistry

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In the previous results, the serotonergic system was suggested as a mechanism of the effect of CMI in the depression—anxiety comorbidity (Casaril et al, 2019b ). More recently, CMI reversed behavioral and biochemical alterations in the dyad pain—depression induced by partial sciatic nerve ligation and possibly modulation of the oxidative system (Birmann et al, 2019 ), and CMI treatment also attenuates depression and cognitive impairment in 4T1 tumor-bearing mice (Maria Casaril et al, 2019 ). All these results instigated us to research more about the CMI treatment in stress models.…”

Section: Introductionmentioning

confidence: 99%

Short- and Long-Term Repeated Forced Swim Stress Induce Depressive-Like Phenotype in Mice: Effectiveness of 3-[(4-Chlorophenyl)Selanyl]-1-Methyl-1H-Indole

Pesarico

Birmann

Pinto

et al. 2020

Front. Behav. Neurosci.

Self Cite

View full text Add to dashboard Cite

“…Previous related studies showed that the gut microbiota, especially Clostridiales, Lachnospiraceae , and fermented terpenoids, such as crocin-I and lycopene, produce antiinflammatory effects against depression ( 21 , 66 ). Interestingly, we found that during the secondary metabolites, the tryptophan metabolite 3-[(4-chlorophenyl) selanyl]-1-methyl-1H-indole, which has been shown to significantly regulate immune, inflammatory, and nervous system diseases ( 67 ), was increased by the P. histicola treatment. Previous studies revealed that indoles, the microbial metabolites of tryptophan, interacted with pregnane X receptors to improve mucosal homeostasis and barrier function ( 68 ).…”

Section: Discussionmentioning

confidence: 99%

Prevotella histicola Mitigated Estrogen Deficiency-Induced Depression via Gut Microbiota-Dependent Modulation of Inflammation in Ovariectomized Mice

Huang

Liu

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

BackgroundEstrogen deficiency-induced depression is closely associated with an imbalance in intestinal microbiota and inflammation. Prevotella histicola (P. histicola), an emerging probiotic, apparently improves inflammatory responses. This study aims to verify the antidepressant-like effects of P. histicola and clarify its potential mechanisms.MethodsMice were treated with P. histicola and cohousing after ovariectomy (OVX). The changes in depression-like behaviors among mice were examined by behavioral tasks, and alterations in the microbiota were detected through 16S rRNA sequencing. Changes in neuronal injury, protein synthesis, inflammatory factors, intestinal permeability, and nerve proliferation were observed by H&E, Nissl staining, qRT-PCR, western blotting, and immunofluorescence.ResultsP. histicola significantly reduces depression-like behaviors and neuronal damage induced by estrogen deficiency. Additionally, P. histicola significantly increases the abundance of intestinal flora, especially Lactobacillus and Akkermansia. Meanwhile, the cohoused mice also had a better emotional state and neutral structure compared with OVX mice. P. histicola was also found to upregulate tight junction proteins ZO-1, occludin, claudin-1, and MUC2 in the ileum and colon and reduce the levels of inflammatory factors VCAM, MCP-1, IL-6, IL-8, and TNF-α, mainly in the ileum, colon, and decrease the expression of COX-2, TLR4, Myd88, JNK, MCP-1, IL-6, IL-8, and TNF-α in the hippocampus. Moreover, significant downregulation of apoptosis (caspase-3 and caspase-8) and upregulation of neurotrophic factors (BDNF and Ki-67) were observed after P. histicola treatment.ConclusionOur data show that P. histicola significantly mitigates depression of OVX mice through improvement in intestinal microbiota to repair intestinal leakage and inhibit central inflammation to promote the expression of BDNF for hippocampal neurogenesis. P. histicola may be therapeutically beneficial for PMD.

show abstract

The antioxidant and immunomodulatory compound 3-[(4-chlorophenyl)selanyl]-1-methyl-1H-indole attenuates depression-like behavior and cognitive impairment developed in a mouse model of breast tumor

Cited by 30 publications

References 63 publications

“Green Is the Color”: An Update on Ecofriendly Aspects of Organoselenium Chemistry

“Green Is the Color”: An Update on Ecofriendly Aspects of Organoselenium Chemistry

Short- and Long-Term Repeated Forced Swim Stress Induce Depressive-Like Phenotype in Mice: Effectiveness of 3-[(4-Chlorophenyl)Selanyl]-1-Methyl-1H-Indole

Prevotella histicola Mitigated Estrogen Deficiency-Induced Depression via Gut Microbiota-Dependent Modulation of Inflammation in Ovariectomized Mice

Contact Info

Product

Resources

About