2020
DOI: 10.3390/ijms21207456
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The Antioxidant Capacity In Vitro and In Vivo of Polysaccharides From Bergenia emeiensis

Abstract: Polysaccharides from Bergenia emeiensis (PBE) showed a robust antioxidant ability on scavenging free radicals in vitro. However, the further antioxidant potential in cell level and in vivo was still unknown. Therefore, in this present study, the protective effect of PBE on human cervical carcinoma cell (Hela) cells and Caenorhabditis elegans against oxidative stress was evaluated. The results showed PBE could reduce the reactive oxygen species (ROS) level in Hela cells and promote the mitochondrial membrane po… Show more

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Cited by 13 publications
(6 citation statements)
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“…Polysaccharide are macromolecular compounds constituted of a variety of monosaccharides or monosaccharide derivatives, with various biological activities, such as anti-inflammatory 12 , anti-tumoral 5 , anti-oxidative 13 , anti-viral, and immunity booster 14 , 15 . Considering the complex structure, the diversity in biological activities and sources, and good application prospects of many polysaccharides, these compounds have been gaining increasing attention.…”
Section: Introductionmentioning
confidence: 99%
“…Polysaccharide are macromolecular compounds constituted of a variety of monosaccharides or monosaccharide derivatives, with various biological activities, such as anti-inflammatory 12 , anti-tumoral 5 , anti-oxidative 13 , anti-viral, and immunity booster 14 , 15 . Considering the complex structure, the diversity in biological activities and sources, and good application prospects of many polysaccharides, these compounds have been gaining increasing attention.…”
Section: Introductionmentioning
confidence: 99%
“…Many flavonoids and polysaccharides from Bergenia species have shown antioxidation and anti-inflammatory effect [18,19]. BGN is a colorless crystalline protein coumarin and a C-glycoside of 4-O-methyl gallic acid that is involved in antioxidant, anti-inflammatory, antiarthritic, antidiabetic, and neuroprotective activities in vitro [20].…”
Section: Discussionmentioning
confidence: 99%
“…Antioxidants are chemicals that bind free radicals and drastically decrease or prevent substrate oxidation [ 18 , 19 ]. They limit free radical damage by blocking free radicals from damaging lipids, protein amino acids, polyunsaturated fatty acids, and the double bonds of DNA bases [ 20 , 21 , 22 ].…”
Section: Introductionmentioning
confidence: 99%