The Antioxidant Effect of Small Extracellular Vesicles Derived from Aloe vera Peels for Wound Healing

Kim, Min Kang; Choi, Young Keun; Cho, Seung Hee; Choi, Ji Suk; Cho, Yong Woo

doi:10.1007/s13770-021-00367-8

Cited by 70 publications

(46 citation statements)

References 63 publications

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“…Also, Kim et al produced many large vesicles by ultra-centrifuging at 100,000× g for 70 min when isolating ADNVs. To obtain smaller ADNVs, the filtration and ultrafiltration were used [ 29 ]. However, it was more complex, and may even reduce the yield of ADNVs, which was not conducive to mass production of vesicles.…”

Section: Resultsmentioning

confidence: 99%

“…Aloe as a mature medicinal herb has been reported with antioxidant, anti-inflammatory, anti-bacterial and other activities [ 28 ]. Currently, the nanovesicles derived from aloe (ADNVs) have been isolated and utilized in the studies of wound healing [ 29 ], NLRP3 inflammasome activity inhibition [ 30 ] and mitigating Insulin Resistance and Chronic Inflammation [ 31 ]. However, the current ADNVs isolation always used the similar method for EVs isolation.…”

Section: Introductionmentioning

confidence: 99%

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Aloe derived nanovesicle as a functional carrier for indocyanine green encapsulation and phototherapy

et al. 2021

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Background Cancer is one of the devastating diseases in the world. The development of nanocarrier provides a promising perspective for improving cancer therapeutic efficacy. However, the issues with potential toxicity, quantity production, and excessive costs limit their further applications in clinical practice. Results Herein, we proposed a nanocarrier obtained from aloe with stability and leak-proofness. We isolated nanovesicles from the gel and rind of aloe (gADNVs and rADNVs) with higher quality and yield by controlling the final centrifugation time within 20 min, and modulating the viscosity at 2.98 mPa S and 1.57 mPa S respectively. The gADNVs showed great structure and storage stability, antioxidant and antidetergent capacity. They could be efficiently taken up by melanoma cells, and with no toxicity in vitro or in vivo. Indocyanine green (ICG) loaded in gADNVs (ICG/gADNVs) showed great stability in both heating system and in serum, and its retention rate exceeded 90% after 30 days stored in gADNVs. ICG/gADNVs stored 30 days could still effectively damage melanoma cells and inhibit melanoma growth, outperforming free ICG and ICG liposomes. Interestingly, gADNVs showed prominent penetrability to mice skin which might be beneficial to noninvasive transdermal administration. Conclusions Our research was designed to simplify the preparation of drug carrier, and reduce production cost, which provided an alternative for the development of economic and safe drug delivery system. Graphical Abstract

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Aloe derived nanovesicle as a functional carrier for indocyanine green encapsulation and phototherapy

et al. 2021

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“…Plant EVs were discovered in the 1960s, but little is known about them. A recent review suggested that plant EVs are involved in plant immune system modulation, plant defense response, plant-microbe symbiosis, and mediate intercellular communication and cross-kingdom communication by shuttling RNAs, proteins, and bioactive compounds [ 106 , 107 ]. Plant EVs share many properties with mammalian and bacterial EVs, and they have huge therapeutic potential, including anti-inflammatory, anti-tumor, mammalian microbiota modulation, and drug delivery [ 108 ].…”

Section: Plant Evs In Skin Improvementmentioning

confidence: 99%

“…Studies explored the application of plant EVs in skin diseases and found that they promoted skin regeneration just like mammalian EVs [ 109 ]. These findings aroused increasing interest in plant EVs in the cosmeceutical field, highlighting them as an ‘animal-free ingredient’ [ 107 ]. Research on various sources of plant-derived EVs was summarized in Table 4 .…”

Section: Plant Evs In Skin Improvementmentioning

confidence: 99%

“…A recent study identified that the peel of Aloe vera exhibited more antioxidant activity than other sections [ 112 ]. Thus, EVs from Aloe vera peels (A-EVs) were isolated and investigated [ 107 ]. A-EVs showed good cytocompatibility on human skin cells, reduced the level of intracellular reactive oxygen species (ROS), and significantly upregulated the antioxidant defense signals, i.e., nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), CAT, and SOD, of keratinocytes.…”

Section: Plant Evs In Skin Improvementmentioning

confidence: 99%

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Extracellular Vesicles in Facial Aesthetics: A Review

Kee

Al-Masawa

et al. 2022

IJMS

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Facial aesthetics involve the application of non-invasive or minimally invasive techniques to improve facial appearance. Currently, extracellular vesicles (EVs) are attracting much interest as nanocarriers in facial aesthetics due to their lipid bilayer membrane, nanosized dimensions, biological origin, intercellular communication ability, and capability to modulate the molecular activities of recipient cells that play important roles in skin rejuvenation. Therefore, EVs have been suggested to have therapeutic potential in improving skin conditions, and these highlighted the potential to develop EV-based cosmetic products. This review summarizes EVs’ latest research, reporting applications in facial aesthetics, including scar removal, facial rejuvenation, anti-aging, and anti-pigmentation. This review also discussed the advanced delivery strategy of EVs, the therapeutic potential of plant EVs, and clinical studies using EVs to improve skin conditions. In summary, EV therapy reduces scarring, rejuvenates aging skin, and reduces pigmentation. These observations warrant the development of EV-based cosmetic products. However, more efforts are needed to establish a large-scale EV production platform that can consistently produce functional EVs and understand EVs’ underlying mechanism of action to improve their efficacy.

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Alpha‐ketoglutaric acid based polymeric particles for cutaneous wound healing

Jaggarapu

Ghosh

Johnston

et al. 2023

J Biomedical Materials Res

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Metabolites are not only involved in energy pathways but can also act as signaling molecules. Herein, we demonstrate that polyesters of alpha-ketoglutararte (paKG) can be generated by reacting aKG with aliphatic diols of different lengths, which release aKG in a sustained manner. paKG polymer-based microparticles generated via emulsion-evaporation technique lead to faster keratinocyte wound closures in a scratch assay test. Moreover, paKG microparticles also led to faster wound healing responses in an excisional wound model in live mice. Overall, this study shows that paKG MPs that release aKG in a sustained manner can be used to develop regenerative therapeutic responses.

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The Antioxidant Effect of Small Extracellular Vesicles Derived from Aloe vera Peels for Wound Healing

Cited by 70 publications

References 63 publications

Aloe derived nanovesicle as a functional carrier for indocyanine green encapsulation and phototherapy

Aloe derived nanovesicle as a functional carrier for indocyanine green encapsulation and phototherapy

Extracellular Vesicles in Facial Aesthetics: A Review

Alpha‐ketoglutaric acid based polymeric particles for cutaneous wound healing

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