The antioxidant effect of tannic acid on the in vitro copper-mediated formation of free radicals

Andrade, Roberto G.; Dalvi, Luana Taquette; Silva, José Maria C.; Lopes, George K.B.; Alonso, Antônio; Hermes‐Lima, Marcelo

doi:10.1016/j.abb.2005.02.016

Cited by 148 publications

(81 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among these, hydrolyzable tannins (including TA) are derivatives of gallic acid (3,4,5-trihydroxyl benzoic acid), characterized by a variable number of gallate moieties esterified to a core phenol (29). Similar to other polyphenols, tannins have antioxidant/free radical scavenging, antiviral/bacterial, anticarcinogenic, antimutagenic, and anti-inflammatory properties (29,(61)(62)(63). Given these pleiotropic biological activities, TA has yielded promising clinical results against cancer (61), myocardial infarction (64), and renal failure (65).…”

Section: Discussionmentioning

confidence: 99%

Tannic Acid Is a Natural β-Secretase Inhibitor That Prevents Cognitive Impairment and Mitigates Alzheimer-like Pathology in Transgenic Mice

Mori

Rezai‐Zadeh

Naoki

et al. 2012

Journal of Biological Chemistry

166

105

View full text Add to dashboard Cite

Background: Recent focus has been given to anti-amyloidogenic naturally occurring polyphenols known as flavonoids. Results:The polyphenol tannic acid prevented behavioral impairment and mitigated Alzheimer disease-like pathology. Conclusion: Tannic acid may be prophylactic for Alzheimer disease by inhibiting ␤-secretase activity and mitigating brain pathology. Significance: This nutraceutical approach offers a new class of drug for inhibiting ␤-secretase with few if any side effects.

show abstract

Section: Discussionmentioning

confidence: 99%

Tannic Acid Is a Natural β-Secretase Inhibitor That Prevents Cognitive Impairment and Mitigates Alzheimer-like Pathology in Transgenic Mice

Mori

Rezai‐Zadeh

Naoki

et al. 2012

Journal of Biological Chemistry

166

105

View full text Add to dashboard Cite

show abstract

“…Between these are highlighted ferulic acid (79) , carotenoids (80) , tannic acid (81) , DHB (82) , flavonoids (83) .…”

Section: Ligands Effects On Fenton Reactionmentioning

confidence: 99%

Fenton Reaction Driven by Iron Ligands

Salgado

Melín

Contreras

et al. 2013

J. Chil. Chem. Soc.

107

View full text Add to dashboard Cite

One of the most important sources of reactive oxygen species (ROS) in biological systems is the Fenton reaction. In this, the Fe 2+ or Fe 3+ reacts with H 2 O 2 to produce ROS as the hydroxyl radical (•OH), superoxide radical (O 2 •-) and singlet oxygen ( 1 O 2 ). The main ROS, responsible for the high oxidizing power of the Fenton reaction, is not clear. Some authors claim that the principal reactive species is •OH, while others propose a ferryl specie (Fe 4+ or [FeO] 2+ ) (1,2) . Recently, have been proposed that the kind of reaction species produced depends mainly of pH and the iron composition of the coordination sphere. This is highlighted for Fe 3+ , because in mono and (some) bis-complexes Fe 3+ is reduced to Fe 2+ and there are some positions occupied by water or hydroxide ligands, readily to be exchanged by H 2 O 2 . On the other hand, in tris-complexes there are not any positions occupied by water or hydroxide, avoiding the formation of peroxo-complexes, necessary for Fenton or Fenton like reaction.The 1,2-dihydroxybenzenes (DHBs) have been described as modulators of Fenton reaction. The DHBs driven Fenton reaction have been used for environmental applications as an advanced oxidation process. Furthermore, these systems participate in different biological process, as the wood biodegradation by fungi and oxidative stress in neurodegenerative diseases.In this review, the effect of 1,2-dihydroxybenzenes on the activated species production by the Fenton and Fenton like reaction will be discussed and its participation in different systems.

show abstract

“…In addition, its antioxidant properties can result from free radical scavenging activities but ability to chelate metal ions also play an important role (Karamac, 2009b). It has been considered that the binding of metal ions with tannins can stabilize the oxidative damage produced by these ions (Andrade et al, 2005). Moreover, pomegranate bark converted into activated carbon has been identified as an effective adsorbent for removing Cr(VI) ions from wastewater (Nemr, 2009).…”

Section: Discussionmentioning

confidence: 99%

Punica granatum L. protects mice against hexavalent chromium-induced genotoxicity

Ávila

Guerra

Borges

et al. 2013

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

This study investigated the chemoprotective effects of Punica granatum L. (Punicaceae) fruits alcoholic extract (PGE) on mice exposed to hexavalent chromium [Cr(VI)]. Animals were pretreated with PGE (25, 50 or 75 mg/kg/day) for 10 days and subsequently exposed to a sub-lethal dose of Cr(VI) (30 mg/kg). The frequency of micronucleated polychromatic erythrocytes in the bone marrow was investigated and the Cr(VI) levels were measured in the kidneys, liver and plasm. For the survival analysis, mice were previously treated with PGE for 10 days and exposed to a single lethal dose of Cr(VI) (50 mg/kg). Exposure to a sub-lethal dose of Cr(VI) induced a significant increase in the frequency of micronucleated cells. However, the prophylactic treatment with PGE led to a reduction of 44.5% (25 mg/kg), 86.3% (50 mg/kg) and 64.2% (75 mg/kg) in the incidence of micronuclei. In addition, the 50 mg/kg dose of PGE produced a higher chemoprotective effect, since the survival rate was 90%, when compared to that of the non-treated group. In these animals, reduced amounts of chromium were detected in the biological materials, in comparison with the other groups. Taken together, the results demonstrated that PGE exerts a protective effect against Cr(VI)-induced genotoxicity. Uniterms INTRODUCTIONChromium occurs naturally in the environment in different oxidation states, where Cr(III) and Cr(VI) are the most prevalent. The hexavalent form is usually linked with oxygen and is a strong oxidizing agent. Studies have shown that Cr(VI) is a mutagenic, carcinogenic and teratogenic agent, which easily penetrates the cell membrane in the form of chromate anion (Barceloux, 1999;Acharya et al., 2006;Nickens et al., 2010;Chang et al., 2011;Okello et al., 2012). Its molecular mechanisms of toxicity are not yet fully known, but it is believed that the intracellular increase in the production of reactive oxygen species (ROS) is probably a key factor in inducing cell damage (Ye et al., 1999;Wu et al., 2012). These reactive species can cause damage to macromolecules such as DNA, proteins and lipids, thereby inhibiting their functions (Valko et al., 2007;Yan et al., 2012) and may even trigger apoptotic cell death (Liu, Chen, 2006;Liu et al., 2008).Cr(VI) has been widely used in metallurgical, refractory and chemical industries. It has been considered a potent occupational carcinogen among workers involved in electrodeposition, metal finishes/welding, wood preservatives, organic synthesis procedures and in leather tanning (Barceloux, 1999;Shrivastava et al., 2002;Acharya et al., 2006;Nickens et al., 2010). In such activities occupational exposure to Cr(VI)-contaminated dust and aerosols occurs predominantly through inhalation or skin contact (Zagrodzki et al., 2007). Non-occupational exposure to Cr(VI) can also occur through cigarette smoke, automobile emissions and the inappropriate disposal of chromium-containing waste in the environment (O'Brien et al., 2003;Russo et al., 2005).The literature has shown that the administration of antioxidant agents ...

show abstract

The antioxidant effect of tannic acid on the in vitro copper-mediated formation of free radicals

Cited by 148 publications

References 50 publications

Tannic Acid Is a Natural β-Secretase Inhibitor That Prevents Cognitive Impairment and Mitigates Alzheimer-like Pathology in Transgenic Mice

Tannic Acid Is a Natural β-Secretase Inhibitor That Prevents Cognitive Impairment and Mitigates Alzheimer-like Pathology in Transgenic Mice

Fenton Reaction Driven by Iron Ligands

Punica granatum L. protects mice against hexavalent chromium-induced genotoxicity

Contact Info

Product

Resources

About