The antioxidant role of coenzyme Q

Bentinger, Magnus; Brismar, Kerstin; Dallner, Gustav

doi:10.1016/j.mito.2007.02.006

Cited by 464 publications

(368 citation statements)

References 68 publications

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“…It is known for a long time as a potent antioxidant, acting either as a primary scavenger of free radicals or in the regeneration of tocopherol. CoQ10 is also involved in oxidative phosphorylation as an electron transporter and is therefore involved in energy homeostasis [17][18][19][20]. Data obtained in vitro even suggest its antiinflammatory potency [21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice

Sohet

Neyrinck

Pachikian

et al. 2009

Biochemical Pharmacology

150

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Please cite this article as: Sohet FM, Neyrinck AM, Pachikian BD, de Backer FC, Bindels LB, Niklowitz P, Menke T, Cani PD, Delzenne NM, Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice, Biochemical Pharmacology (2008Pharmacology ( ), doi:10.1016Pharmacology ( /j.bcp.2009 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Aims:The aim of the study is to investigate the effect of the antioxidant coenzyme Q10 (CoQ10) on hepatic metabolic and inflammatory disorders associated with diet-induced obesity and glucose intolerance.Methods: C57bl6/j mice were fed for 8 weeks, either a control diet (CT) or a high fat diet plus 21% fructose in the drinking water (HFF). CoQ10 supplementation was performed in this later condition (HFFQ).Results HFF mice exhibit increased energy consumption, fat mass development, fasting glycemia and insulinemia and impaired glucose tolerance. HFF treatment promoted the expression of genes involved in reactive oxygen species production (NADPH oxidase), inflammation (CRP, STAMP-2) and metabolism (CPT1) in the liver. CoQ10 supplementation decreased the global hepatic mRNA expression of inflammatory and metabolic stresses markers without changing obesity and tissue lipid peroxides compared to HFF mice. HFF diets paradoxically decreased TBARS (reflecting lipid peroxides) levels in liver, muscle and adipose tissue versus CT group, an effect related to vitamin E content of the diet. Conclusion:In conclusion, HFF model promotes glucose intolerance and obesity by a mechanism independent on the level of tissue peroxides. CoQ10 tends to decrease hepatic stress gene expression, independently of any modulation of lipid peroxidation, which is classically considered as its most relevant effect.

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Section: Introductionmentioning

confidence: 99%

Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice

Sohet

Neyrinck

Pachikian

et al. 2009

Biochemical Pharmacology

150

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“…Segundo Bentinger et al 31 a coenzima Q10 tem como função primária prevenir a produção de radicais livres e a iniciação do processo de peroxidação lipídica.…”

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Efeito da coenzima Q10 nos danos oxidativos induzidos pela L-tiroxina no músculo sóleo de ratos

Silva

Medeiros

Guelfi

et al. 2015

Rev Bras Med Esporte

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INTRODUÇÃO: os músculoesqueléticos são tecidos dinâmicos que podem alterar suas características fenotípicas proporcionando melhor adaptação funcional com estímulos variados. A L-tiroxina é um hormônio produzido pela glândula tireoide e tem sido utilizada como modelo experimental para estimulação de estresse oxidativo no músculo esquelético. A coenzima Q10 é uma provitamina lipossolúvel sintetizada endogenamente e naturalmente encontrada em alimentos como carne vermelha, peixes, cereais, brócolis e espinafre. Apresenta propriedade antioxidante e tem potencial no tratamento de doenças degenerativas e neuromusculares.OBJETIVO: avaliar o efeito protetor da coenzima Q10 no músculo sóleo de ratos frente aos danos oxidativos provocados pela L-tiroxina.MÉTODOS: os ratos foram distribuídos em quatro grupos de seis animais cada: Grupo 1 controle; Grupo 2 coenzima Q10; Grupo 3 L-tiroxina e Grupo 4 coenzima Q10 e L-tiroxina. Após a eutanásia, o sangue dos animais foi colhido e foi analisada a atividade sérica das enzimas creatina quinase CK e aspartato aminotransferase AST. No homogenato do músculo sóleo foram avaliados fatores relacionados ao estresse oxidativo.RESULTADOS: a coenzima Q10 protegeu o músculo sóleo dos danos provocados pela L-tiroxina e favoreceu a manutenção da atividade das enzimas antioxidantes glutationa redutase e glutationa peroxidase, da concentração de glutationa reduzida e oxidada, além de evitar a lipoperoxidação.CONCLUSÃO: os resultados indicam que a coenzima Q10 protege o músculo sóleo de ratos dos danos oxidativos provocados pela L-tiroxina.

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“…In mammalian mitochondria Q functions to integrate the respiratory chain with many aspects of metabolism by serving as an electron acceptor for glycerol-3-phosphate, dihydroorotate, choline, sarcosine, sulfide, and several amino acid and fatty acylCoA dehydrogenases [4,5]. QH 2 also functions as a crucial lipidsoluble antioxidant [6] and decreased levels of Q are associated with mitochondrial, cardiovascular, kidney and neurodegenerative diseases [7][8][9][10][11]. A better understanding of the enzymatic steps and organization of the polypeptides and cofactors required for Q biosynthesis will aid efforts to determine how the content of this important lipid can be regulated for optimal metabolism and health.…”

Section: Introductionmentioning

confidence: 99%

“…Whereas each of the coq null mutants lacks the designated Coq polypeptide [20], several coq mutants harboring certain amino acid substitution mutations show a less drastic block in Q biosynthesis as compared to coq null mutants. For example, certain coq7 point mutants retain steady-state levels of the Coq7 polypeptide and accumulate demethoxy-Q 6 (DMQ 6 ), a late-stage Q-intermediate missing just one methoxy group [22,23]. Some of the Coq polypeptides physically interact -biotinylated Coq3 co-purifies with Coq4 [18], and Coq9 tagged with the hemagglutinin epitope co-purifies with Coq4, Coq5, Coq6, and Coq7 polypeptides [20].…”

Section: Introductionmentioning

confidence: 99%

Coenzyme Q supplementation or Over-Expression of the Yeast Coq8 Putative Kinase Stabilizes Multi-Subunit Coq Polypeptide Complexes in Yeast Coq Null Mutants

Xie

Allan

et al. 2013

Free Radical Biology and Medicine

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The antioxidant role of coenzyme Q

Cited by 464 publications

References 68 publications

Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice

Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice

Efeito da coenzima Q10 nos danos oxidativos induzidos pela L-tiroxina no músculo sóleo de ratos

Coenzyme Q supplementation or Over-Expression of the Yeast Coq8 Putative Kinase Stabilizes Multi-Subunit Coq Polypeptide Complexes in Yeast Coq Null Mutants

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