The Antioxidant Role of Paraoxonase 1 and Vitamin E in Three Autoimmune Diseases

Ramadan, Ronnie; Tawdy, Amira El; Hay, Rania Abdel; Rashed, Laila Ahmed; Tawfik, Dan S.

doi:10.1159/000342124

Cited by 46 publications

(42 citation statements)

References 29 publications

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“…Oxidative stress, defined as 'the imbalance between oxidants and antioxidants in favour of the oxidants, potentially leading to damage' has been associated with several autoimmune diseases, such as colon malignancies, multiple sclerosis, neurodegenerative diseases, psoriasis, vitiligo and alopecia areata [14][15][16][17]. Oxidative damage may be involved in the pathogenesis of these autoimmune diseases.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Status and Oxidative Stress in Patients with Chronic ITP

et al. 2013

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The aim of this study was to establish the antioxidant status and oxidative stress in adult patients with chronic idiopathic thrombocytopenic purpura (ITP). Eighty-four patients diagnosed with chronic ITP were studied. Fiftyeight age-matched healthy subjects were selected as controls. Serum nitrogen monoxide ( NO), oxidized glutathione (GSSG), malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS), superoxide dismutase (SOD), hydrogen peroxide enzyme (CAT), glutathione peroxidase (GSH-Px), glutathione (GSH) were evaluated by enzyme-linked immunosorbent assay (ELISA). It was found that serum SOD, CAT, GSH-Px, GSH, TAS levels were significantly lower in patients with chronic ITP than controls (all P < 0.05), while serum NO, GSSG, MDA, TOS values were significantly higher (P < 0.05). The number of platelet showed a negative correlation with NO, GSSG, MDA, TOS, respectively,while platelet number showed a positive correlation with SOD, CAT, GSH-Px, GSH, TAS. These findings suggested that oxidants were increased and antioxidants were decreased in patients with chronic ITP, these may be prominent factors in destructing the platelet membrane. The scavenging of oxygen radical provides a theoretical basis for the treatment of ITP patients.

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Section: Discussionmentioning

confidence: 99%

Antioxidant Status and Oxidative Stress in Patients with Chronic ITP

et al. 2013

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“…While no biomarkers are available for the monitoring of psoriasis, a recent analysis identified 53 separate clinical measures of psoriasis severity and outcome [31], none of which meets all the validation criteria required for an ideal clinical score [31,32,33,34]. The Psoriasis Area and Severity Index (PASI) [35] represents the most common score for the assessment of psoriasis severity in clinical trials and practice.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Histological and Clinical Course of Psoriasis: A Pilot Investigation by Reflectance Confocal Microscopy during Goeckerman Treatment

Archid¹,

Duerr²,

Patzelt

et al. 2016

Skin Pharmacol Physiol

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Alterations of the skin microvasculature are known to play an important role in the development and maintenance of psoriatic skin lesions. In this study, we investigated lesional skin in 11 psoriatic patients during a modified Goeckerman treatment using reflectance confocal microscopy (RCM) to study the relationship between clinical clearance and histological normalization of psoriatic skin and the significance of histological abnormalities on the course of disease. The treatment regimen resulted in a significant reduction of the Psoriasis Area and Severity Index (PASI) as well as capillary and papillary diameters (p < 0.0001). The capillary and papillary diameters were still enlarged when compared to those in normal skin (p < 0.001). Capillary and papillary diameters correlated with each other prior to and after treatment (correlation coefficient = 0.63 and 0.64, p = 0.01 and 0.002, respectively) but not with the PASI. Capillary and papillary diameters after treatment and percentage reduction of the PASI during treatment seemed to be better predictors for the clinical course of relapse than the PASI after treatment. These findings make the subclinical changes of psoriatic skin vessels and dermal papillae a legitimate target for treatment. Further investigations of a large group of patients are needed to evaluate the potential of RCM findings as successor of the PASI in the monitoring of psoriasis.

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“…Free radicals are generated in the skin as a result of solar radiation and environmental hazards [2,3,4]. For instance, smog and ozone can destroy cells and cell compartments if their concentration exceeds a critical threshold.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Carotenoids: The Mirror of Lifestyle?

Lademann¹,

Köcher²,

et al. 2014

Skin Pharmacol Physiol

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Carotenoids could serve as marker substances of the antioxidant status of the human skin. In the present study, an optical skin scanner was used to analyse the carotenoid concentration obtained from 4 volunteers over a period of 13 days. The measurements were taken daily at different time points. In addition, the volunteers were asked to keep track of their daily nutritional behaviour and stress situations in a diary. It was found that the carotenoid values reflect clearly the nutritional behaviour and stress situations of the volunteers. While a steady, increased intake of fruit and vegetables resulted in a gradual increase in the dermal carotenoid values for several days, stressful situations entailed an immediate decline in these values. Although the impact of healthy nutrition on the antioxidant protection system is generally known and notwithstanding the small number of cases, the present study clearly demonstrates that the avoidance and/or reduction of stress is similarly important in order not to counteract or nullify the results achieved by healthy nutrition.

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The Antioxidant Role of Paraoxonase 1 and Vitamin E in Three Autoimmune Diseases

Cited by 46 publications

References 29 publications

Antioxidant Status and Oxidative Stress in Patients with Chronic ITP

Antioxidant Status and Oxidative Stress in Patients with Chronic ITP

Relationship between Histological and Clinical Course of Psoriasis: A Pilot Investigation by Reflectance Confocal Microscopy during Goeckerman Treatment

Cutaneous Carotenoids: The Mirror of Lifestyle?

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