The Antiproliferative Effect of Dietary Fiber Phenolic Compounds Ferulic Acid and<i>p</i>-Coumaric Acid on the Cell Cycle of Caco-2 Cells

Janicke, Birgit; Hegardt, Cecilia; Krogh, Morten; Önning, Gunilla; Åkesson, Björn; Cirenajwis, Helena; Oredsson, Stina

doi:10.1080/01635581.2011.538486

Cited by 158 publications

(102 citation statements)

References 49 publications

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“…Dietary fiber is an important component in a healthy diet, and a strong association between its intake and decreased incidence of colon cancer has been evidenced in several studies [12]. Chemotherapy is an effective way to treat many types of cancers, but the cost of treatment is a major public health concern in developing countries.…”

Section: Colon Cancermentioning

confidence: 99%

“…Additionally, Janicke et al [12] have investigated the effects of FA and p-CoA treatment on global gene expression in Caco-2 colon cancer cells. They have found that FA and p-CoA treatment delayed cell cycle progression and the expressions of a number of genes involved in centrosome assembly, such as RABGAP1 and CEP2, were upregulated by FA treatment as well as the gene for the S phase checkpoint protein SMC1L1 regulation, a total of 517 genes were significantly affected by FA and 901 by p-CoA.…”

Section: Role Of Phenolic Acids On Colon Cancermentioning

confidence: 99%

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Anticancer Properties of Phenolic Acids in Colon Cancer – A Review

LS¹,

NJA²

2016

J Nutr Food Sci

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Consumption of fruits and vegetables is associated with lower risk of several cancers, particularly colorectal cancer, which is mainly associated to their phytochemical content. A diverse range of phytochemicals, especially phenolic compounds, has been reported to possess important biological properties such as anticancer, antiviral, antioxidant and anti-inflammatory activities. Several factors contribute to the development of colorectal cancer. The scientific evidences support the genetic predisposition, diet, and lifestyle as some of the major contributing factors for colorectal cancer development. In this sense, this review aims to summarize the anticancer activities and the proposed mechanisms of action of phenolic acids with an emphasis in colon cancer through in vitro evidences. The evidences supports the theory of anticancer properties of phenolic acids, although the mechanisms are still not fully understood, but may include scavenging free radicals, induction of enzymes involved in the metabolism of xenobiotics, regulation of gene expression, modulation of cellular signaling pathways including those involved in DNA damage repair, cell proliferation, apoptosis and invasion.

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Section: Colon Cancermentioning

confidence: 99%

Section: Role Of Phenolic Acids On Colon Cancermentioning

confidence: 99%

Anticancer Properties of Phenolic Acids in Colon Cancer – A Review

LS¹,

NJA²

2016

J Nutr Food Sci

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“…The strong antioxidant character of FA is attributed to its unsaturated side chain and phenolic nucleus that spontaneously forms resonance stabilized structures, thus making it an effective antiproliferative agent. FA is a dietary phytochemical that is known to possess antitumor activities against several types of cancers such as colon, gastric, breast and cervical cancers (Janicke et al 2011; Electronic supplementary material The online version of this article (doi:10.1007/s13204-015-0502-y) contains supplementary material, which is available to authorized users. Kampa et al 2004;Kyoungho et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Characterization and anticancer potential of ferulic acid-loaded chitosan nanoparticles against ME-180 human cervical cancer cell lines

et al. 2015

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Ferulic acid (FA) is a widely distributed hydroxycinnamic acid found in various cereals and fruits exhibiting potent antioxidant and anticancer activities. However, due to low solubility and permeability, its availability to biological systems is limited. Non-toxic chitosan-tripolyphosphate pentasodium (CS-TPP) nanoparticles (NPs) are used to load sparingly soluble molecules and drugs, increasing their bioavailability. In the present work, we have encapsulated FA into the CS-TPP NPs to increase its potential as a therapeutic agent. Different concentrations of FA were tested to obtain optimum sized FA-loaded CS-TPP nanoparticles (FA/CS-TPP NPs) by ionic gelation method. Nanoparticles were characterized by scanning electron microscopy, Fourier transformation infrared spectroscopy (FTIR), thermogravimetric analyses and evaluated for their anticancer activity against ME-180 human cervical cancer cell lines. The FTIR spectra confirmed the encapsulation of FA and thermal analysis depicted its degradation profile. A concentration-dependent relationship between FA encapsulation efficiency and FA/ CS-TPP NPs diameter was observed. Smooth and spherical FA-loaded cytocompatible nanoparticles with an average diameter of 125 nm were obtained at 40 lM FA conc. The cytotoxicity of 40 lM FA/CS-TPP NPs against ME-180 cervical cancer cell lines was found to be higher as compared to 40 lM native FA. Apoptotic morphological changes as cytoplasmic remnants and damaged wrinkled cells in ME-180 cells were visualized using scanning electron microscopic and fluorescent microscopic techniques. Data concluded that chitosan enveloped FA nanoparticles could be exploited as an excellent therapeutic drug against cancer cells proliferation.

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“…15 To further stabilize glucagon at alkaline pH, we became interested in the potential use of ferulic acid, which has been reported to minimize aggregation of the Alzheimer's peptide, amyloid-beta. 22,23 Ferulic acid is found in various foods and beverages, [24][25][26] and is reported to have neuroprotective, 27 antineoplastic, 28,29 and antihypertensive 30,31 actions due to its antioxidant properties. Due to its beneficial effects on inhibiting peptide aggregation, we investigated ferulic acid for its ability to stabilize glucagon.…”

mentioning

confidence: 99%

A Novel, Stable, Aqueous Glucagon Formulation Using Ferulic Acid as an Excipient

Bakhtiani

Caputo

Castle

et al. 2014

J Diabetes Sci Technol

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Background: Commercial glucagon is unstable due to aggregation and degradation. In closed-loop studies, it must be reconstituted frequently. For use in a portable pump for 3 days, a more stable preparation is required. At alkaline pH, curcumin inhibited glucagon aggregation. However, curcumin is not sufficiently stable for long-term use. Here, we evaluated ferulic acid, a stable breakdown product of curcumin, for its ability to stabilize glucagon.Methods: Ferulic acid-formulated glucagon (FAFG), composed of ferulic acid, glucagon, L-methionine, polysorbate-80, and human serum albumin in glycine buffer at pH 9, was aged for 7 days at 37°C. Glucagon aggregation was assessed by transmission electron microscopy (TEM) and degradation by high-performance liquid chromatography (HPLC). A cell-based protein kinase A (PKA) assay was used to assess in vitro bioactivity. Pharmacodynamics (PD) of unaged FAFG, 7-day aged FAFG, and unaged synthetic glucagon was determined in octreotide-treated swine. Results:No fibrils were observed in TEM images of fresh or aged FAFG. Aged FAFG was 94% intact based on HPLC analysis and there was no loss of bioactivity. In the PD swine analysis, the rise over baseline of glucose with unaged FAFG, aged FAFG, and synthetic native glucagon (unmodified human sequence) was similar.Conclusions: After 7 days of aging at 37°C, an alkaline ferulic acid formulation of glucagon exhibited significantly less aggregation and degradation than that seen with native glucagon and was bioactive in vitro and in vivo. Thus, this formulation may be stable for 3-7 days in a portable pump for bihormonal closed-loop treatment of T1D.

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The Antiproliferative Effect of Dietary Fiber Phenolic Compounds Ferulic Acid andp-Coumaric Acid on the Cell Cycle of Caco-2 Cells

Cited by 158 publications

References 49 publications

Anticancer Properties of Phenolic Acids in Colon Cancer – A Review

Anticancer Properties of Phenolic Acids in Colon Cancer – A Review

Characterization and anticancer potential of ferulic acid-loaded chitosan nanoparticles against ME-180 human cervical cancer cell lines

A Novel, Stable, Aqueous Glucagon Formulation Using Ferulic Acid as an Excipient

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