The antipsychotic drug olanzapine altered lipid metabolism in the common carp (Cyprinus carpio L.): Insight from the gut microbiota-SCFAs-liver axis

Chang, Xulu; Shen, Yifeng; Yun, Lili; Wang, Xianfeng; Feng, Junchang; Yang, Guokun; Meng, Xiaolin; Zhang, Jianxin; Su, Xi

doi:10.1016/j.scitotenv.2022.159054

Cited by 15 publications

(11 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fusobacteria primarily consisted of Cetobacterium genera in this study, which are widely recognized as vitamin B 12 and acetate-producing bacteria [ 69 , 70 ], and has an important role in improving intestinal health and nutritional metabolism [ 71 ]. In this study, dietary NSPs supplementation increased the abundance of Cetobacterium , suggesting that dietary NSPs benefit the intestinal health of grass carp.…”

Section: Discussionmentioning

confidence: 99%

Different Types of Non-Starch Polysaccharides Alter the Growth, Intestinal Flora and Serum Metabolite Profile of Grass Carp, Ctenopharyngodon idella

Liu

Zhou

et al. 2022

Metabolites

View full text Add to dashboard Cite

Dietary non-starch polysaccharides (NSPs) broadly influence fish intestinal flora and physiological metabolism, but limited information is available on grass carp (Ctenopharyngodon idella). This study investigated the effects of different types of NSPs on the growth, nutrient metabolism status, gut microbiota, and serum metabolome of grass carp. Fish were fed with diets containing 4.4% insoluble NSPs (INSP), 9.24% soluble NSPs (SNSP), 13.64% NSPs (4.4% INSP + 9.24% SNSP, NSP) and non NSPs (FM), respectively, for 9 weeks. Results showed that dietary SNSP decreased protein efficiency ratio and serum protein content, but increased feed coefficient ratio, feed intake, plasma blood urea nitrogen content, and plasma aspartate aminotransferase activity (AST); conversely, dietary INSP decreased plasma AST activity. Dietary INSP and SNSP increased serum free cholesterol content. Dietary NSPs altered the abundance of dominant bacteria and serum metabolite profiles. The differential metabolites between groups were significantly enriched in amino acid synthesis and metabolic pathways. In conclusion, dietary INSP exhibited a growth-promoting effect compared to SNSP. Dietary INSP is beneficial for improving nutrient metabolism and intestinal health. Moreover, dietary NSPs may regulate the physiological metabolism and feeding behavior of grass carp by altering amino acid synthesis and metabolism.

show abstract

Section: Discussionmentioning

confidence: 99%

Different Types of Non-Starch Polysaccharides Alter the Growth, Intestinal Flora and Serum Metabolite Profile of Grass Carp, Ctenopharyngodon idella

Liu

Zhou

et al. 2022

Metabolites

View full text Add to dashboard Cite

show abstract

“…Activation of liver and adipose tissue PPARγ by SCFAs regulates lipid metabolism by increasing energy expenditure, reducing inflammation in adipose tissue, improving insulin sensitivity, reducing body weight, and decreasing hepatic TG accumulation ( Besten et al, 2015 ). A study in fish showed that the effects of olanzapine on lipid metabolism may be related to the regulation of the gut microbiota–SCFA–PPAR signaling pathway ( Chang et al, 2022 ). The gut microbiome was significantly altered in carp that were administered olanzapine, as evidenced by an increase in the abundance of SCFA-producing bacteria, which led to an increase in the production of SCFAs.…”

Section: Mechanisms Of Sga-induced Disorders Of Lipid Metabolism Medi...mentioning

confidence: 99%

The regulatory effects of second-generation antipsychotics on lipid metabolism: Potential mechanisms mediated by the gut microbiota and therapeutic implications

et al. 2023

View full text Add to dashboard Cite

Second-generation antipsychotics (SGAs) are the mainstay of treatment for schizophrenia and other neuropsychiatric diseases but cause a high risk of disruption to lipid metabolism, which is an intractable therapeutic challenge worldwide. Although the exact mechanisms underlying this lipid disturbance are complex, an increasing body of evidence has suggested the involvement of the gut microbiota in SGA-induced lipid dysregulation since SGA treatment may alter the abundance and composition of the intestinal microflora. The subsequent effects involve the generation of different categories of signaling molecules by gut microbes such as endogenous cannabinoids, cholesterol, short-chain fatty acids (SCFAs), bile acids (BAs), and gut hormones that regulate lipid metabolism. On the one hand, these signaling molecules can directly activate the vagus nerve or be transported into the brain to influence appetite via the gut–brain axis. On the other hand, these molecules can also regulate related lipid metabolism via peripheral signaling pathways. Interestingly, therapeutic strategies directly targeting the gut microbiota and related metabolites seem to have promising efficacy in the treatment of SGA-induced lipid disturbances. Thus, this review provides a comprehensive understanding of how SGAs can induce disturbances in lipid metabolism by altering the gut microbiota.

show abstract

“…Numerous studies had demonstrated that dietary composition played a critical role in maintaining gut flora homeostasis and affecting organismal metabolism (Chang et al, 2023;Wang et al, 2022;Zheng & Wang, 2021). Considering the strong link between gut microbial homeostasis and liver health, it is hypothesized that dysbiosis of the gut microflora may be a significant contributor to liver injury caused by broad bean.…”

Section: Introductionmentioning

confidence: 99%

“…Conversely, short‐chain fatty acids (SCFAs), particularly butyric acid, produced by intestinal flora (e.g., Bacteroides immitis , Bacteroides thickettsii ), contribute to maintaining the integrity of the intestinal barrier and safeguarding liver health (Zheng & Wang, 2021). Numerous studies had demonstrated that dietary composition played a critical role in maintaining gut flora homeostasis and affecting organismal metabolism (Chang et al., 2023; Wang et al., 2022; Zheng & Wang, 2021). Considering the strong link between gut microbial homeostasis and liver health, it is hypothesized that dysbiosis of the gut microflora may be a significant contributor to liver injury caused by broad bean.…”

Section: Introductionmentioning

confidence: 99%

Broad bean (Vicia faba L.) caused abnormal lipid metabolism in grass carp (Ctenopharyngodon idellus) liver: Insight from the gut microbiota–liver axis

Fu,

Ma,

Yang

et al. 2024

Food Frontiers

View full text Add to dashboard Cite

Broad bean (Vicia faba L.) has received attention from the food and animal feed industries as a sustainable, inexpensive, and versatile plant‐based protein source. However, long‐term consumption of broad bean, especially unprocessed ones, can lead to hepatic lipid accumulation. To investigate how broad bean affected hepatic lipid metabolism and its underlying mechanisms, we conducted a multi‐omics analysis of crisp grass carp (Ctenopharyngodon idellus C. et V) model with hepatic steatosis after feeding with single broad bean for 120 days. The glycolysis inhibition, increased de novo lipogenesis, abnormalities in lipid metabolism, and activation of oxidative stress were the key processes involved in broad bean‐induced hepatic lipid accumulation. Disturbances in intestinal flora caused by damage to the intestinal barrier and increased lipopolysaccharide caused by broad bean promoted hepatic lipid accumulation. Reduction of antinutritional factors and balanced diet offer potential strategies to mitigate the liver damage caused by broad bean consumption. Overall, our findings provided a theoretical basis for the wide application of broad bean as animal feeds.

show abstract

The antipsychotic drug olanzapine altered lipid metabolism in the common carp (Cyprinus carpio L.): Insight from the gut microbiota-SCFAs-liver axis

Cited by 15 publications

References 56 publications

Different Types of Non-Starch Polysaccharides Alter the Growth, Intestinal Flora and Serum Metabolite Profile of Grass Carp, Ctenopharyngodon idella

Different Types of Non-Starch Polysaccharides Alter the Growth, Intestinal Flora and Serum Metabolite Profile of Grass Carp, Ctenopharyngodon idella

The regulatory effects of second-generation antipsychotics on lipid metabolism: Potential mechanisms mediated by the gut microbiota and therapeutic implications

Broad bean (Vicia faba L.) caused abnormal lipid metabolism in grass carp (Ctenopharyngodon idellus) liver: Insight from the gut microbiota–liver axis

Contact Info

Product

Resources

About