The antispermatogenic activity of some phenylbismuth(III) O,O′‐dialkyldithiophosphates

Abstract

Ten dialkyldithiophosphate derivatives of phenylbismuth(III) of the type, Ph (3 -n) Bi[S(S)P(OR) 2 ] n [where n = 1; R = Me(1), Et(2), Pri(3), Pr n (4) and Bu n (5); n = 2; R = Me(6), Et(7), Pr i (8), Pr n (9) and Bu n (10)] have been synthesized by the reactions of triphenylbismuth(III) with corresponding dialkyldithiophosphoric acids in 1 : 1 and 1 : 2 stoichiometric ratios, respectively, in stirred benzene solution. The newly synthesized brown colored compounds, 1-10 have been characterized by elemental analyses, molecular weight measurements, IR and NMR ( 1 H, 13 C and 31 P) spectral studies. The ligand diethyldithiophosphoric acid, [(C 2 H 5 O) 2 P(S)SH], and its organobismuth(III) derivatives, compounds 2 and 7 were administered to adult male rats by oral gavage at the dose of 25 mg per kg body weight per day, for 60 days, and their effects were evaluated and compared for changes in testicular morphology, circulatory concentrations of testosterone, FSH and LH, sperm dynamics, fertility index and testicular cell population dynamics.

Synthesis, Spectral and Antimicrobial Studies of Bis (Cyclopentadienyl) Titanium (IV) Bis (O,O’-Dialkyl and Alkylenedithiophosphate) Complexes

“…Derivatives containing other monodentate ligands in addition to dithiophosphate have not been isolated. Dialkyl and alkylenedithiophosphates exhibit a variety of coordination modes of bonding [9]- [12] and their metal complexes have important biochemical, analytical and industrial applications [13]- [17]. The biocidial importance of organophosphorus compounds is well known.…”

O-Tolyl/benzyl dithiocarbonates of phosphorus(III) and (V): syntheses and characterization

“…O-Alkyldithiocarbonates (ROCS 2 -) [1, 2] are an important class of 1,1-dithiolate ligands along with dithiocarbamates (R 2 N-CS 2 -) [3,4], dithiocarboxylates (RCS 2 -), dithiophosphates ((RO) 2 PS 2 -) [5][6][7][8], and other related phosphor-1,1-dithiolate ligands. Metallic derivatives of ROCS 2 -ligands have been known since 1815, when these were first prepared by Zeise, who also termed them xanthates, a name derived from the Greek xanthos (yellow), owing to the yellow color of lead xanthates [9].…”