The antistreptococcal immune responses in children with acute rheumatic fever in Kuwait

Majeed, H. A.; Karaoui, R. M.; Yousof, A. M.; Moussa, M. A. A.; Farwana, S; Khuffash, Faisal A.

doi:10.1080/02724936.1982.11748245

Cited by 2 publications

(3 citation statements)

References 13 publications

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“…Elevated levels of antibodies against extracellular SMs and antigens such as streptolysin 0, hyaluronidase, streptokinase, and DNase B have been detected in sera from children with AGN and ARF (16,24,29). Our results extend earlier findings to show that antibodies against SM, SMgamma, or ETA are similarly elevated in sera from children with poststreptococcal sequelae.…”

Section: Discussionsupporting

confidence: 85%

Antibody levels and in vitro lymphoproliferative responses to Streptococcus pyogenes erythrogenic toxin A and mitogen of patients with rheumatic fever

et al. 1991

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We investigated the in vitro lymphoproliferative responses to a streptococcal mitogen and erythrogenic toxin A of children with acute rheumatic fever (ARF) and patients with chronic rheumatic heart disease (CRHD). Antibody levels to the streptococcal products were also analyzed in the sera of those with ARF or chronic rheumatic heart disease as well as in the sera of children with streptococcal pharyngitis or poststreptococcal glomerulonephritis. Our results demonstrated that the individuals had depressed lymphoproliferative responses during the active stage of rheumatic fever. The depressed responses were not found either to be induced by time-sensitive mitogen-specific suppressor cells or to be related to a dose-response phenomenon. On the other hand, antibody levels to the extracellular mitogens were significantly elevated in the sera of children with ARF compared with the levels in the rest of the groups. The hyperresponsiveness noted among children with ARF was found to be at a quantitative level and was not due to recognition of more epitopes, as determined by Western blotting (immunoblotting). The proffle of immune responsiveness in children with ARF to the streptococcal extracellular mitogens is discussed in relation to the pathogenesis of disease.

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Section: Discussionsupporting

confidence: 85%

Antibody levels and in vitro lymphoproliferative responses to Streptococcus pyogenes erythrogenic toxin A and mitogen of patients with rheumatic fever

et al. 1991

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“…The reason for the lack of serum antibody reactivity to high molecular mass antigens in our study is unclear, but this might be due to differences in either the bacterial strains used and/or in the study populations. As described in , children with ARF have been found previously to have increased serum antibody titres to a number of GAS‐derived proteins including streptolysin O, hyaluronidase, streptokinase, deoxyribonuclease and erythrogenic toxin A [2–5]. The raised antibody titres to CS proteins in ARF patients found in this study might therefore be targeted towards any one or more of these proteins.…”

Section: Discussionsupporting

confidence: 61%

“…Considerable evidence implicates group A streptococcal (GAS) infections in the pathogenesis of these diseases. For example, increased serum concentrations of antibodies to GAS antigens such as streptolysin O, hyaluronidase, streptokinase, deoxyribonuclease and erythrogenic toxin A are found in children with either ARF or acute GN [1–5]. Other Streptococcus pyogenes cell‐associated antigens have also been linked to these diseases, including cell surface M proteins, which have been studied extensively as candidate targets for self‐cross‐reactive autoantibodies [6].…”

Section: Introductionmentioning

confidence: 99%

Serum antibodies to group A streptococcal extracellular and cell-associated antigens in Egyptians with post-streptococcal diseases

Abdel-Rehim¹,

Degnan²,

El-Ghobary³

et al. 2001

FEMS Immunology &Amp; Medical Microbiology

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We investigated serum antibodies to a comprehensive array of group A streptococcal antigens and superantigens in Egyptian subjects. Antibodies to Streptococcus pyogenes cell-associated proteins and to proteins released by rapidly dividing S. pyogenes were compared in four patient groups with different post-streptococcal diseases and in healthy controls. Enzyme-linked immunosorbent assays showed that total Ig and IgG to extracellular antigens were significantly higher in patients with acute rheumatic fever (ARF) compared to healthy controls, but no differences were found in either total Ig or IgG titres to cell-associated proteins between any of the groups. Western blotting showed that multiple extracellular and cell-associated antigens, covering a wide range of molecular masses, were recognised by all sera, including healthy controls. No evidence was obtained for putative dominant antigens associated with any disease group, although a low molecular mass cell-associated protein (approximately 4 kDa) was clearly recognised by two-thirds of subjects irrespective of disease status. These findings demonstrate that raised serum Ig and IgG titres to extracellular, but not cell-associated, S. pyogenes antigens are a feature of ARF in this population, and suggest that multiple S. pyogenes antigens contribute to this response.

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The antistreptococcal immune responses in children with acute rheumatic fever in Kuwait

Cited by 2 publications

References 13 publications

Antibody levels and in vitro lymphoproliferative responses to Streptococcus pyogenes erythrogenic toxin A and mitogen of patients with rheumatic fever

Antibody levels and in vitro lymphoproliferative responses to Streptococcus pyogenes erythrogenic toxin A and mitogen of patients with rheumatic fever

Serum antibodies to group A streptococcal extracellular and cell-associated antigens in Egyptians with post-streptococcal diseases

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