The antitumor activity of several transition metal complexes.

Knigth′s Move in the Periodic Table, From Copper to Platinum,Novel Antitumor Mixed Chelate Copper Compounds, Casiopeinas,Evaluated by an in Vitro Human and Murine Cancer Cell Line Panel

“…A preliminary report of antineoplastic activity was presented (7), also SOD like activity and the induction of apoptosis has been reported (8,9). Casiopefnas have shown cytotoxicity in several munne tumoral cell lines and strong in vivo antitumor activity in routine tumoral models in our preliminar results (10).…”

Structural and reactivity studies on 4,4′-dimethyl-2,2′-bipyridine acetylacetonate copper(II) nitrate (CASIOPEINA III-ia®) with methionine, by UV–visible and EPR techniques

“…The angles between planes are: (Cu O1 C11 C12 C13 O2)/(Cu N1 C5 C6 N2) ¼ 5.71°, (Cu O1 C11 C12 C13 O2)/(Cu O1 O2 N1 N2) ¼ 1.85°, (Cu N1 C5 C6 N2)/(Cu O1 O2 N1 N2) ¼ 3.86°. The distances for the different planes in the stacking are: dmbipy-acac; Cu-acac $ Cu-acac; Cudmbipy $ Cu-dmbipy; and coordination planes are 3.43(2), 3.42(8), 3.31(2) and 3.36 (4) A respectively. From the reaction between Cas III ia NO 3 and methionine a substitution reaction occurs, the aminoacidate is coordinated to Cu(II) and acac is not present in the coordination sphere of the metal ion; methionine is coordinated via -NH 2 , and -COO groups.…”

“…Cas III Ia ClO 4 Cas IV met The three nitrogen atoms and the oxygen atom are coplanar, and the copper atom deviates from the coordination plane (6-7°). The equatorial Cu-N and Cu-O bonds Cu-N(1) ¼ 2.028(2), Cu-N(2) ¼ 1.978 (2),…”

In vitro evaluation of apoptotic effect of bis(acetylacetonato‐k2O,O′)(1,10‐phenanthroline‐k2 N,N′)Zn(II) complex

“…During the last two decades, a series of metal‐derived complexes has been studied for cancer treatment. One particular type of compounds which has been showed its potential against a variety of cancer cell lines is the so‐called cassiopeians ® , developed by Ruiz and coworkers . These compounds were prepared by complexation of copper with different organic ligands, and its activity has been evaluated in vivo for some types of tumors, whereas ruthenium complexes have also reported interesting antiproliferative properties .…”