The Antitumor Effect of Suicide Gene Therapy Using Bifidobacterium infantis–mediated Herpes Simplex Virus Thymidine Kinase/Ganciclovir in a Nude Mice Model of Renal Cell Carcinoma

Intravenous Administration Is an Effective and Safe Route for Cancer Gene Therapy Using the Bifidobacterium-Mediated Recombinant HSV-1 Thymidine Kinase and Ganciclovir

“…BF has been constructed as a solid tumor gene targeting therapy system with optimal antitumor effects when combined with GCV [ 9 , 10 , 21 , 22 , 23 , 27 ]. The targeting and colonization of BF in the tumor center were visualized by Cronin et al [ 40 ].…”

“…Therefore, BF is an optimal cancer gene therapy vector due to the anaerobic properties. In recent years, BF has been widely used as a cancer-targeting gene therapy vector [ 10 , 21 , 22 , 25 , 26 , 27 , 28 , 29 ].…”

Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system induces FasL and TNFR2 mediated antitumor apoptosis in solid tumors

“…The Herpes Simplex Virus thymidine kinase/ganciclovir (HSV-TK + GCV) system is currently one of the best-studied tumor suicide gene therapy systems [ 9 – 11 ]. When expressed in tumors, TK converts the non-toxic precursor GCV into GCV- 3-phosphate, a toxic substance that kills tumor cells.…”

Antitumor mechanisms of bifidobacteria (Review)

“…infantis exhibited sustainable antitumor growth activity via downregulating peroxiredoxin-1 through the nuclear factor-κB signaling pathway in a rodent bladder cancer model (23). A previous study by Xiao et al (24) used B. longum subsp. infantis thymidine kinase (TK) to treat tumor-bearing nude mice, and revealed that B. longum subsp.…”