The antitumoral effect of the American mistletoe Phoradendron serotinum (Raf.) M.C. Johnst. (Viscaceae) is associated with the release of immunity-related cytokines

Alonso-Castro, Ángel Josabad; Juárez-Vázquez, María del Carmen; Domínguez, Fabiola; González-Sánchez, Ignacio; Estrada–Castillón, Eduardo; López-Toledo, Gabriela; Chávez, Marı́a Isabel; Cerbón, Marco; García‐Carrancá, Alejandro

doi:10.1016/j.jep.2012.06.018

Cited by 16 publications

(14 citation statements)

References 23 publications

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“…serotinum , one of the most studied is Viscum album L. also referred to as European mistletoe or Iscador. Chemical extracts or a lectin rich Iscador extract can inhibit growth of TC‐1 tumors (Alonso‐Castro et al ., ), gliobastoma (Podlech et al ., ) and HepG2 cells in vitro (Choi et al ., ). In human clinical trials, adjuvant use of Iscador with traditional chemotherapy such as gemcitabine provides greater overall survival rates in patients with pancreatic carcinoma (Matthes et al ., ) or lung cancer (Salzer and Havelec, ).…”

Section: Discussionmentioning

confidence: 99%

High Throughput Screening of Natural Products for Anti‐mitotic Effects in MDA‐MB‐231 Human Breast Carcinoma Cells

Mazzio

Badisa

Mack

et al. 2013

Phytotherapy Research

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Some of the most effective anti-mitotic microtubule-binding agents, such as paclitaxel (Taxus brevifolia) were originally discovered through robust NCI botanical screenings. In this study, a high-through microarray format was utilized to screen 897 aqueous extracts of commonly used natural products (0.00015–0.5 mg/ml) relative to paclitaxel for anti-mitotic effects (independent of toxicity) on proliferation of MDA-MB-231 cells. The data obtained showed that less than 1.34 % tested showed inhibitory growth (IG50) properties <0.0183 mg/ml. The most potent anti-mitotics (independent of toxicity) were Mandrake root (Podophyllum peltatum), Truja Twigs (Thuja occidentalis), Colorado desert mistletoe (Phoradendron flavescens), Tou Gu Cao Speranskia Herb (Speranskia tuberculata), Bentonite Clay, Bunge Root (Pulsatilla chinensis), Brucea Fruit (Brucea javanica), Madder Root (Rubia tinctorum), Gallnut of Chinese Sumac (Melaphis chinensis), Elecampane Root (Inula Helenium), Yuan Zhi Root (Polygala tenuifolia), Pagoda Tree Fruit (Melia Toosendan), Stone Root (Collinsonia Canadensis) and others such as American Witchhazel, Arjun and Bladderwrack. The strongest tumoricidal herbs identified from amongst the subset evaluated for anti-mitotic properties were wild yam (Dioscorea villosa), beth-root (Trillium Pendulum) and alkanet-root (Lithospermum canescens). Additional data was obtained on a lesser-recognized herb: (Speranskia tuberculata) which showed growth inhibition on BT-474 (human ductal breast carcinoma) and Ishikawa (human endometrial adenocarcinoma) cells with ability to block replicative DNA synthesis leading to G2 arrest in MDA-MB-231 cells. In conclusion, these findings present relative potency of natural anti-mitotic resources effective against human breast carcinoma MDA-MB-231 cell division.

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Section: Discussionmentioning

confidence: 99%

High Throughput Screening of Natural Products for Anti‐mitotic Effects in MDA‐MB‐231 Human Breast Carcinoma Cells

Mazzio

Badisa

Mack

et al. 2013

Phytotherapy Research

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“…Further studies with Lophophora williamsii , as well as the isolation and purification of its active compounds, are highly recommended. Among the in vivo studies, an ethanol extract from Phoradendron serotinum leaves, tested from 1 to 10 mg/kg i.p., showed immunostimulatory effects, in a dose-dependent manner, by increasing the levels of IFN- γ , IL-2, and IL-6 in serum from C57BL/6 mice bearing TC-1 tumor [ 41 ]. The immunostimulatory effects obtained using in vitro studies were confirmed in in vivo studies for some plant species such as Mollugo verticillata , Phoradendron serotinum , and Petiveria alliacea and compounds such as maturin acetate ( Figure 1 ).…”

Section: Medicinal Plants From Mexico Central America and The Camentioning

confidence: 99%

“…Taking this into consideration, further studies with plants from the Smilax and Juglans genera should be carried out. Furthermore, mistletoe species such as Phoradendron brachystachyum and Psittacanthus calyculathus could be a good option for discovering immunostimulatory agents since the related species Phoradendron serotinum showed good immunostimulatory activity [ 41 ]. However, the toxicity of the mistletoe species should be assessed.…”

Section: Medicinal Plants Used As Immunostimulants Without Pharmacmentioning

confidence: 99%

Medicinal Plants from Mexico, Central America, and the Caribbean Used as Immunostimulants

Alonso-Castro

Juárez-Vázquez

Campos-Xolalpa

2016

Evidence-Based Complementary and Alternative Medicine

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A literature review was undertaken by analyzing distinguished books, undergraduate and postgraduate theses, and peer-reviewed scientific articles and by consulting worldwide accepted scientific databases, such as SCOPUS, Web of Science, SCIELO, Medline, and Google Scholar. Medicinal plants used as immunostimulants were classified into two categories: (1) plants with pharmacological studies and (2) plants without pharmacological research. Medicinal plants with pharmacological studies of their immunostimulatory properties were subclassified into four groups as follows: (a) plant extracts evaluated for in vitro effects, (b) plant extracts with documented in vivo effects, (c) active compounds tested on in vitro studies, and (d) active compounds assayed in animal models. Pharmacological studies have been conducted on 29 of the plants, including extracts and compounds, whereas 75 plants lack pharmacological studies regarding their immunostimulatory activity. Medicinal plants were experimentally studied in vitro (19 plants) and in vivo (8 plants). A total of 12 compounds isolated from medicinal plants used as immunostimulants have been tested using in vitro (11 compounds) and in vivo (2 compounds) assays. This review clearly indicates the need to perform scientific studies with medicinal flora from Mexico, Central America, and the Caribbean, to obtain new immunostimulatory agents.

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“…A dose as low as 1–5 pg/ml dose could exert cancer cell-specific toxicity. Alonso-Castro et al (2012) evaluated cytotoxicity of ethanolic extracts of P. serotinum injected intraperitoneally into C57BL/6 mice implanted with TC-1 cells for 25 consecutive days. The extract at the dose 10 mg/kg inhibited the tumour growth by 69 %, increasing the release of IL-2, IL-6, and IFN-γ.…”

Section: Anti-angiogenesis Antiproliferation and Apoptosismentioning

confidence: 99%

Emerging roles of mistletoes in malignancy management

Patel

Panda²

2013

3 Biotech

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Mistletoes are a group of obligate plant semi-parasites in the order Santalales. These clumps of plants growing on a wide range of host plants have been traditionally regarded as medicinal repositories. However, current scientific discoveries have validated their health potentials like never before. Their extracts containing alkaloids, viscotoxins, lectins, and polysaccharides have been evidenced to possess a myriad biological potentials including cancer inhibition. Mistletoes have emerged as promising alternative therapy against colon, oral, lung, and pancreas cancers. The plant extracts bolster immunity, delay tumour initiation and progression, kill malignant tumours, stabilize DNA, alleviate side effects of chemotherapeutics, improve the lifespan, and coping ability of cancer patients and survivors. A range of proprietary formulations viz. Iscador, Eurixor, Helixor, Lektinol, Isorel, Iscucin, Abnoba-viscum and recombinant lectin ML-1 are already being commercialized. This review presents an informative account on the recent developments in mistletoe-mediated cancer management. The underlying mechanisms, possibilities and limitations in cancer therapeutic development are outlined for kindling both researcher and public interest.

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The antitumoral effect of the American mistletoe Phoradendron serotinum (Raf.) M.C. Johnst. (Viscaceae) is associated with the release of immunity-related cytokines

Cited by 16 publications

References 23 publications

High Throughput Screening of Natural Products for Anti‐mitotic Effects in MDA‐MB‐231 Human Breast Carcinoma Cells

High Throughput Screening of Natural Products for Anti‐mitotic Effects in MDA‐MB‐231 Human Breast Carcinoma Cells

Medicinal Plants from Mexico, Central America, and the Caribbean Used as Immunostimulants

Emerging roles of mistletoes in malignancy management

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