The antiviral and coronavirus-host protein pathways inhibiting properties of herbs and natural compounds - Additional weapons in the fight against the COVID-19 pandemic?

Fuzimoto, Andréa D.; Isidoro, Ciro

doi:10.1016/j.jtcme.2020.05.003

Cited by 103 publications

(100 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, the repurposing drugs, including favipiravir, remdesivir, lopinavir, ritonavir, nebulized α-interferon, chloroquine, hydroxychloroquine, ribavirin, and interferon (IFN), have been shown to be effective for the treatment of COVID-19. Apart from this, some therapeutics are in clinical trials, such as peptide vaccine (mRNA-1273) ( 198 ) and antibody therapies ( 205 ). Recently, plasma therapy showed promising results for COVID-19 treatment ( 206 , 207 ).…”

Section: Psms Can Be Effective Over Synthetic Drugs Against Sars Cov-mentioning

confidence: 99%

Plants Metabolites: Possibility of Natural Therapeutics Against the COVID-19 Pandemic

et al. 2020

View full text Add to dashboard Cite

COVID-19, a disease induced by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2), has been the cause of a worldwide pandemic. Though extensive research works have been reported in recent days on the development of effective therapeutics against this global health crisis, there is still no approved therapy against SARS-CoV-2. In the present study, plant-synthesized secondary metabolites (PSMs) have been prioritized to make a review focusing on the efficacy of plant-originated therapeutics for the treatment of COVID-19. Plant metabolites are a source of countless medicinal compounds, while the diversity of multidimensional chemical structures has made them superior to treat serious diseases. Some have already been reported as promising alternative medicines and lead compounds for drug repurposing and discovery. The versatility of secondary metabolites may provide novel antibiotics to tackle MDR (Multi-Drug Resistant) microbes too. This review attempted to find out plant metabolites that have the therapeutic potential to treat a wide range of viral pathogens. The study includes the search of remedies belonging to plant families, susceptible viral candidates, antiviral assays, and the mode of therapeutic action; this attempt resulted in the collection of an enormous number of natural therapeutics that might be suggested for the treatment of COVID-19. About 219 plants from 83 families were found to have antiviral activity. Among them, 149 plants from 71 families were screened for the identification of the major plant secondary metabolites (PSMs) that might be effective for this pandemic. Our investigation revealed that the proposed plant metabolites can serve as potential anti- SARS-CoV-2 lead molecules for further optimization and drug development processes to combat COVID-19 and future pandemics caused by viruses. This review will stimulate further analysis by the scientific community and boost antiviral plant-based research followed by novel drug designing.

show abstract

Section: Psms Can Be Effective Over Synthetic Drugs Against Sars Cov-mentioning

confidence: 99%

Plants Metabolites: Possibility of Natural Therapeutics Against the COVID-19 Pandemic

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Our literature survey revealed that the triterpenoids like 3β-friedelanol from Euphorbia neriifolia, quinone-methide triterpenoids extracted from Tripterygium regelii (celastraceae) and glycyrrhizin from Glycyrrhiza glabra are experimentally proven to inhibit the effects of SARS-CoV (first identified in Guangdong, China in 2002) [ [13] , [14] , [15] , [16] ]. Also, our recent molecular docking studies of phytochemicals against the therapeutic protein targets of SARS-CoV-2 supported the effective binding affinity with limonin, a triterpenoid found in citrus [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

In silico ADMET and molecular docking study on searching potential inhibitors from limonoids and triterpenoids for COVID-19

Vardhan

Sahoo

2020

Computers in Biology and Medicine

187

113

View full text Add to dashboard Cite

Virtual screening of phytochemicals was performed through molecular docking, simulations, in silico ADMET and drug-likeness prediction to identify the potential hits that can inhibit the effects of SARS-CoV-2. Considering the published literature on medicinal importance, 154 phytochemicals with analogous structure from limonoids and triterpenoids were selected to search potential inhibitors for the five therapeutic protein targets of SARS-CoV-2, i.e., 3CLpro (main protease), PLpro (papain-like protease), SGp-RBD (spike glycoprotein-receptor binding domain), RdRp (RNA dependent RNA polymerase) and ACE2 (angiotensin-converting enzyme 2). The in silico computational results revealed that the phytochemicals such as glycyrrhizic acid, limonin, 7-deacetyl-7-benzoylgedunin, maslinic acid, corosolic acid, obacunone and ursolic acid were found to be effective against the target proteins of SARS-CoV-2. The protein-ligand interaction study revealed that these phytochemicals bind with the amino acid residues at the active site of the target proteins. Therefore, the core structure of these potential hits can be used for further lead optimization to design drugs for SARS-CoV-2. Also, the medicinal plants containing these phytochemicals like licorice, neem, tulsi, citrus and olives can be used to formulate suitable therapeutic approaches in traditional medicines.

show abstract

“…Nonetheless, the efficacy and safety of these compounds in COVID-19 patients is still unclear. Moreover, modes of administration, the health of the patients' digestive system, and disease stage may limit the clinical usefulness of such formulations and compounds (Fuzimoto and Isidoro, 2020). Xu et al (2012) demonstrated that cryptotanshinone at 0.5 µM effectively exhibited anti-TMPRSS2 activity (Figure 3).…”

Section: Natural Products Targeting the Tmprss2mentioning

confidence: 99%

Medicinal Plants as Sources of Active Molecules Against COVID-19

2020

View full text Add to dashboard Cite

The Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2) or novel coronavirus (COVID-19) infection has been declared world pandemic causing a worrisome number of deaths, especially among vulnerable citizens, in 209 countries around the world. Although several therapeutic molecules are being tested, no effective vaccines or specific treatments have been developed. Since the COVID-19 outbreak, different traditional herbal medicines with promising results have been used alone or in combination with conventional drugs to treat infected patients. Here, we review the recent findings regarding the use of natural products to prevent or treat COVID-19 infection. Furthermore, the mechanisms responsible for this preventive or therapeutic effect are discussed. We conducted literature research using PubMed, Google Scholar, Scopus, and WHO website. Dissertations and theses were not considered. Only the situation reports edited by the WHO were included. The different herbal products (extracts) and purified molecules may exert their anti-SARS-CoV-2 actions by direct inhibition of the virus replication or entry. Interestingly, some products may block the ACE-2 receptor or the serine protease TMPRRS2 required by SARS-CoV-2 to infect human cells. In addition, natural products were shown to inhibit the SARS-CoV-2 life-cycle related proteins such as papain-like or chymotrypsin-like proteases. In conclusion, we suggest that natural products could be used alone or in combination as alternative medicines to treat/ prevent COVID-19 infection. Moreover, their structures may offer clues for the development of anti-SARS-CoV-2 drugs.

show abstract

The antiviral and coronavirus-host protein pathways inhibiting properties of herbs and natural compounds - Additional weapons in the fight against the COVID-19 pandemic?

Cited by 103 publications

References 103 publications

Plants Metabolites: Possibility of Natural Therapeutics Against the COVID-19 Pandemic

Plants Metabolites: Possibility of Natural Therapeutics Against the COVID-19 Pandemic

In silico ADMET and molecular docking study on searching potential inhibitors from limonoids and triterpenoids for COVID-19

Medicinal Plants as Sources of Active Molecules Against COVID-19

Contact Info

Product

Resources

About