The antiviral effects of nitric oxide

Powell, Kenneth L.; Baylis, S.A.

doi:10.1016/s0966-842x(00)88884-8

Cited by 12 publications

(9 citation statements)

References 15 publications

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“…Speculations about heat sensitive inhibition of DNAse activity37 or about heat sensitive inhibition of infectivity38 have been disproved. For an induction of an intensified synthesis of nitric oxide (NO), which, depending on concentration, can cause antiviral effects via oxidative mechanisms,39,40 the duration of application is far too short 21,41. It is known that there is a bi-phase vasogenic response: metabolic interactions via induction of inducible NO synthase can be expected at the earliest after approximately 10 minutes 22,42…”

Section: Discussionmentioning

confidence: 99%

The use of local concentrated heat versus topical acyclovir for a herpes labialis outbreak: results of a pilot study under real life conditions

Wohlrab¹,

Voß²,

Müller³

et al. 2013

CCID

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BackgroundFrequent outbreak of herpes labialis can affect quality of life by prodromes like burning, itching, and swelling. Topical applied preparations aim to shorten the duration of symptoms, inhibit the virus replication and/or accelerate the healing process. Local concentrated heat (LCH) can reduce burning, itching, or swelling of the skin by influence of mechano-heat sensitive afferent neurons.Patients and methodsTo examine the effectiveness of two different topical applications (LCH versus topical acyclovir [TACV]) under real life conditions, we conducted a prospective, observational, reference-controlled cohort pilot study with 103 patients. Occurrence of prodromal burning, itching, swelling, and quality of life were assessed.ResultsThe LCH observation group (OG) showed a significantly faster improvement in all symptoms after 1-day of application than the TACV OG. The burden and duration of disease was lower and shorter in the LCH OG than in the TACV OG.ConclusionsThe prodromal symptoms in recurrent herpes labialis were attenuated more effectively by LCH than by TACV.

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Section: Discussionmentioning

confidence: 99%

The use of local concentrated heat versus topical acyclovir for a herpes labialis outbreak: results of a pilot study under real life conditions

Wohlrab¹,

Voß²,

Müller³

et al. 2013

CCID

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“…It is characterized by a parenchymal infiltration of activated cytotoxic T lymphocytes-the main cause of hepatic injury. Antiviral activity of NO is well documented [148][149][150][151][152]. It has been shown to be able to inhibit the growth of DNA and RNA viruses, such as herpes simplex virus, Coxsackie B3 virus, and Japanese encephalitis virus [152][153][154].…”

Section: Viral Hepatitis Infectionmentioning

confidence: 99%

Recent Advances on the Roles of NO in Cancer and Chronic Inflammatory Disorders

Kanwar

Burrow

et al. 2009

CMC

225

155

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Nitric oxide (NO) is a short-life molecule produced by the enzyme known as the nitric oxide synthase (NOS), in a reaction that converts arginine and oxygen into citrulline and NO. There are three isoforms of the enzyme: neuronal NOS (nNOS, also called NOS1), inducible NOS (iNOS or NOS2), and endothelial NOS (eNOS or NOS3). It is now known that each of these isoforms may be expressed in a variety of tissues and cell types. This paper is a review of the current knowledge of various functions of NO in diseases. We discuss in more detail its role in Cancer, the role of NO in myocardial pathophysiology, in central nervous system (CNS) pathologies. Other diseases such as inflammation, asthma, in chronic liver diseases, inflammatory bowel disease (IBD), arthritis, are also discussed. This review also covers the role of NO in cardiovascular, central nervous, pancreas, lung, gut, kidney, myoskeletal and chronic liver diseases (CLD). The ubiquitous role that the simple gas nitric oxide plays in the body, from maintaining vascular homeostasis and fighting infections to acting as a neurotransmitter and its role in cancer, has spurred a lot of interest among researchers all over the world. Nitric oxide plays an important role in the physiologic modulation of coronary artery tone and myocardial function. Nitric oxide from iNOS appears to be a key mediator of such glial-induced neuronal death. The high sensitivity of neurons to NO is partly due to NO causing inhibition of respiration, rapid glutamate release from both astrocytes and neurons, and subsequent excitotoxic death of the neurons.

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“…Antiviral activity of NO is well documented 38,39. It has been shown to be able to inhibit the growth of DNA and RNA viruses, such as herpes simplex virus,40 Coxsackie B3 virus,41 and Japanese encephalitis virus 42.…”

Section: Viral Hepatitis Infectionmentioning

confidence: 99%

Nitric Oxide in Liver Diseases

Hon

Lee

Khoo

2002

Annals of the New York Academy of Sciences

106

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Research on the free radical gas, nitric oxide (NO), during the past twenty years is one of the most rapid growing areas in biology. NO seems to play a part in almost every organ and tissue. However, there is considerable controversy and confusion in understanding its role. The liver is one organ that is clearly influenced by NO. Acute versus chronic exposure to NO has been associated with distinct patterns of liver disease. In this paper we review and discuss the involvement of NO in various liver diseases collated from observations by various researchers. Overall, the important factors in determining the beneficial versus harmful effects of NO are the amount, duration, and site of NO production. A low dose of NO serves to maximize blood perfusion, prevent platelet aggregation and thrombosis, and neutralize toxic oxygen radicals in the liver during acute sepsis and reperfusion events. NO also demonstrates antimicrobial and antiapoptosis properties during acute hepatitis infection and other inflammatory processes. However, in the setting of chronic liver inflammation, when a large sustained amount of NO is present, NO might become genotoxic and lead to the development of liver cancer. Additionally, during prolonged ischemia, high levels of NO may have cytotoxic effects leading to severe liver injury. In view of the various possible roles that NO plays, the pharmacologic modulation of NO synthesis is promising in the future treatment of liver diseases, especially with the emergence of selective NO synthase inhibitors and cell-specific NO donors.

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The antiviral effects of nitric oxide

Cited by 12 publications

References 15 publications

The use of local concentrated heat versus topical acyclovir for a herpes labialis outbreak: results of a pilot study under real life conditions

The use of local concentrated heat versus topical acyclovir for a herpes labialis outbreak: results of a pilot study under real life conditions

Recent Advances on the Roles of NO in Cancer and Chronic Inflammatory Disorders

Nitric Oxide in Liver Diseases

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