The anxiolytic buspirone shifts coping strategy in novel environmental context of mice with different anxious phenotype

Horváth, János; Szögi, Titanilla; Müller, Géza; Szegedi, Viktor

doi:10.1016/j.bbr.2013.04.014

Cited by 10 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, in a spatial discrimination task [ 26 ], removal of environmental enrichment (a negative event) has been shown to reduce the extent to which rats explored previously inaccessible (i.e., ambiguous) arms of a radial arm maze. Rats showed a higher preference for familiar arms, indicating that reduced welfare (induced by removal of enrichment) may override the animal’s natural tendency to explore ambiguous, potentially aversive environments [ 27 ]. The present study expanded upon this idea and used a “free choice” spatial discrimination test on an eight-arm radial maze to assess affective state in mice.…”

Section: Introductionmentioning

confidence: 99%

An Exploration Based Cognitive Bias Test for Mice: Effects of Handling Method and Stereotypic Behaviour

et al. 2015

View full text Add to dashboard Cite

Behavioural tests to assess affective states are widely used in human research and have recently been extended to animals. These tests assume that affective state influences cognitive processing, and that animals in a negative affective state interpret ambiguous information as expecting a negative outcome (displaying a negative cognitive bias). Most of these tests however, require long discrimination training. The aim of the study was to validate an exploration based cognitive bias test, using two different handling methods, as previous studies have shown that standard tail handling of mice increases physiological and behavioural measures of anxiety compared to cupped handling. Therefore, we hypothesised that tail handled mice would display a negative cognitive bias. We handled 28 female CD-1 mice for 16 weeks using either tail handling or cupped handling. The mice were then trained in an eight arm radial maze, where two adjacent arms predicted a positive outcome (darkness and food), while the two opposite arms predicted a negative outcome (no food, white noise and light). After six days of training, the mice were also given access to the four previously unavailable intermediate ambiguous arms of the radial maze and tested for cognitive bias. We were unable to validate this test, as mice from both handling groups displayed a similar pattern of exploration. Furthermore, we examined whether maze exploration is affected by the expression of stereotypic behaviour in the home cage. Mice with higher levels of stereotypic behaviour spent more time in positive arms and avoided ambiguous arms, displaying a negative cognitive bias. While this test needs further validation, our results indicate that it may allow the assessment of affective state in mice with minimal training—a major confound in current cognitive bias paradigms.

show abstract

Section: Introductionmentioning

confidence: 99%

An Exploration Based Cognitive Bias Test for Mice: Effects of Handling Method and Stereotypic Behaviour

et al. 2015

View full text Add to dashboard Cite

show abstract

“…One more important issue is that the anxiety experienced by an animal (both “trait” and “state” anxiety) is not the unitary physiological state of the brain. Anxiety reactions reveal the complicated neurophysiological basis and different expression in different test environments [ 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. The fact that traditional indicators of anxiety and their changes in response to AT were not similar in EPM and puzzle-box in LB and SB mice is not surprising.…”

Section: Discussionmentioning

confidence: 99%

Cognitive Test Solution in Mice with Different Brain Weights after Atomoxetine

Perepelkina

Полетаева

2023

Neurology International

View full text Add to dashboard Cite

In this paper, the data are presented concerning different reactions to seven daily injections of atomoxetine in two mouse strains differing in relative brain weight. Atomoxetine affected the performance in a puzzle-box cognitive test in a complicated way—the large brain mice were less successful at task solutions (presumably because they were not afraid of the brightly lit test box), while the small brain strain of atomoxetine treated mice solved the task more successfully. The behavior of all atomoxetine treated animals was more active in an aversive situation (an unescapable slippery funnel, (analogous to the Porsolt test) and the time of immobility decreased significantly in all atomoxetine treated mice. The general patterns of behavioral reactions to atomoxetine in the cognitive test and other interstrain differences demonstrated in these experiments made it possible to suggest that differences in ascending noradrenergic projections between the two strains used exist. Further analysis of the noradrenergic system in these strains is needed (and further analysis of the effects of drugs which affect noradrenergic receptors).

show abstract

“…Although a difference in the reaction to earlylife adversity, such as suboptimal maternal care or exposure to stress, may program the brain differentially and lead to different adult phenotype (Horváth et al 2013;Maccari et al 2014;Maniam et al 2014), little is known about the postnatal reactivity of inbred anxious models and its contribution to the development of their adult anxiety. In this paper we aim to clarify this issue.…”

Section: Introductionmentioning

confidence: 99%

Sex differences in ultrasonic vocalization and hormonal stress response of an anxious mice strain during the early postnatal period

Csikota

Horváth

Szegedi

et al. 2020

Integrative Physiology

Self Cite

View full text Add to dashboard Cite

Development of anxiolytics requires animal models; therefore anxious (AX) and nonanxious (nAX) mice have been selectively bred based upon their adult behaviour in reaction to handling. Since inadequate response to postnatal challenges may have lifelong consequences, we aimed to determine whether alterations in postnatal stress-coping may contribute to the state of anxiety in adult AX mice. Maternal separation-induced ultrasonic vocalization (MS-USV) was studied in one-week-old nAX-AX mice and one week later the endocrine stress response was measured after lipopolysaccharide (LPS) stimulation, a model of bacterial infection, with special focus on sex differences. It was established that AX females produced a significantly lower frequency and duration of MS-USV than nAX female mice. USV emitted by AX males showed only a tendency to be reduced compared to nAX males. LPS injection generated a significantly increased adrenocorticotropin release in nAX mice only and with no sex-related difference observed. Resting corticosterone levels were higher in AX mice compared to nAX, however, this difference reached the level of significance only in females. LPS-injection was able to induce significant corticosterone elevation with markedly higher levels in AX females than nAX females. To sum up, we conclude that females are more susceptible to the influence of stressors during the early postnatal period, as they exhibited more pronounced reactions. The adult state anxiety of the strain was not paralleled by MS-USV during the perinatal period. Thus, the question arises if MS-USV indeed reflects anxiety only. According to our expectation, AX animals had higher baseline stress-hormone levels, but their reactivity to stressors was altered, which may have contributed to their supposed adult phenotype.

show abstract

The anxiolytic buspirone shifts coping strategy in novel environmental context of mice with different anxious phenotype

Cited by 10 publications

References 30 publications

An Exploration Based Cognitive Bias Test for Mice: Effects of Handling Method and Stereotypic Behaviour

An Exploration Based Cognitive Bias Test for Mice: Effects of Handling Method and Stereotypic Behaviour

Cognitive Test Solution in Mice with Different Brain Weights after Atomoxetine

Sex differences in ultrasonic vocalization and hormonal stress response of an anxious mice strain during the early postnatal period

Contact Info

Product

Resources

About