The Anyang Esophageal Cancer Cohort Study: Study Design, Implementation of Fieldwork, and Use of Computer-Aided Survey System

Liu, Fangfang; Guo, Fangcen; Zhou, Yue; He, Zhonghu; Tian, Xiuyun; Guo, Chuanhai; Ning, Tao; Pan, Yaqi; Cai, Hong; Ke, Yang

doi:10.1371/journal.pone.0031602

Cited by 37 publications

(50 citation statements)

References 26 publications

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“…A population-based prospective cohort study of risk factors for esophageal cancer in rural Anyang, China, has been previously described (16). This investigation of oral HPV was conducted in 6 of the 9 villages involved in the original cohort study in 2009 to 2011.…”

Section: Methodsmentioning

confidence: 99%

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Oral Human Papillomavirus Infection and Its Risk Factors among 5,410 Healthy Adults in China, 2009–2011

Hang

Liu

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Despite the established link between oral human papillomavirus (HPV) infection and a subset of oropharyngeal squamous cell carcinoma (OSCC), little is known about the epidemiology of oral HPV infection among healthy adults in China.Methods: Oral swab specimens and questionnaires were collected from 5,410 individuals (ages 25-65 years). HPV DNA in oral exfoliated cells was tested by general primer-mediated (SPF1/GP6þ) PCR and sequencing. Univariate and multivariate analyses were performed to assess the associations between exposure factors and oral infection.Results: Alpha mucosal HPV types were detected in 0.67% [95% confidence interval (CI), 0.47%-0.93%] of 5,351 b-globin-positive specimens, and cutaneous HPV in 5.46% (95% CI, 4.86%-6.10%). HPV 16 and 3 were the most prevalent types of a mucosal (0.43%; 95% CI, 0.27%-0.64%) and cutaneous HPV (4.17%; 95% CI, 3.65%-4.74%), respectively. The prevalence of a mucosal HPV decreased with increasing age (25-65 years) from 0.93% to 0.36% (P trend ¼ 0.033), and was associated with self-reported history of oral disease [adjusted odds ratio (OR), 4.78; 95% CI, 1.07-21.41]. In 1,614 heterosexual couples, cutaneous HPV in one partner was found to increase the other partner's risk of cutaneous HPV infection (adjusted OR, 2.33; 95% CI, 1.22-4.48).Conclusions: Oral HPV infection, particularly with a mucosal types, is rare among healthy adults in China. A younger age and a history of oral disease imply higher risk of a mucosal HPV infection.

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Section: Methodsmentioning

confidence: 99%

“…Using SPF1/GP6þ-mediated PCR and sequencing, a broad spectrum of HPV types could be tested (HPV 3,6,7,10,11,16,18,26,27,29,30,31,32,33, …”

Section: Classification Of Hpv Typesmentioning

confidence: 99%

Oral Human Papillomavirus Infection and Its Risk Factors among 5,410 Healthy Adults in China, 2009–2011

Hang

Liu

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…In the current study, we established a cohort of rural Chinese men on the basis of a large-scale esophageal cancer cohort study (20), and followed up their genital HPV status for seven biannual visits. The aim of this study is to investigate the type-specific prevalence, incidence, and clearance of HPV infection in men from rural China, and to evaluate potential risk factors.…”

Section: Introductionmentioning

confidence: 99%

Prevalence, Incidence, Clearance, and Associated Factors of Genital Human Papillomavirus Infection among Men: A Population-Based Cohort Study in Rural China

Liu

Zhang

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: The natural history of human papillomavirus (HPV) infection in men on a population base has rarely been studied in general, particularly among Chinese men.Methods: A total of 1,286 men ages 25 to 65 years from rural China were enrolled during 2009-2010 and their genital HPV infection status was assessed biannually for up to seven visits using PCR and sequencing methods. Prevalence analysis was performed among men with at least one valid HPV result (N ¼ 1,279) and men with at least two consecutive HPV results (N ¼ 1,059) were included in incidence and clearance analyses (median follow-up time, 31.8 months; interquartile range, 15.4-37.9 months).Results: The prevalence and incidence of any HPV type, oncogenic, and nononcogenic HPV were 17.8%, 6.4%, 12.4%, and 14.6, 4.9, 10.8 per 1,000 person months, respectively. The median duration of infection with any HPV type, oncogenic, and nononcogenic HPV was 11.5, 6.8, and 11.5 months, respectively. The number of lifetime sexual partners was consistently associated with increased risk of prevalent and incident infection of HPV. Men ages 25 to 50 years had a higher incidence and longer duration of HPV infection than older men (51-65 years).Conclusions and Impact: This epidemiologic investigation provides basic information of genital HPV infection among the Chinese male population; these data are crucial for the consideration of primary strategies against HPV-related carcinoma in the Chinese male and female population. Cancer Epidemiol Biomarkers Prev; 23(12); 2857-65. Ó2014 AACR.

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“…Lobach et al 8 describe a Computer-Assisted Management Protocol of care guidelines for diabetes mellitus, and improve the compliance with diabetes care standards. Liu et al 9 use a computer-aided survey system to investigate the association of HPV infection and esophageal squamous cell carcinoma tissues, and it may be helpful to researchers in developing countries. European Organization for the Research and Treatment of Cancer (EO-RTC) designed a complex quality assurance program to ensure safe and effective treatment delivery 10 .…”

Section: Discussionmentioning

confidence: 99%

Abstracts of the Medical Engineering and Bioinformatics 2015 (MEB 2015), China, 7 June 2015

2015

Basic Clin Pharma Tox

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Aims: The laparoscopy reduces the damage to body and shortens the postoperative recovery period, so it is becoming the standard surgical operation. However, the indirect method of observing and manipulating in laparoscopy impairs the surgeon's eye-hand coordination, which makes it difficult to carry out a laparoscopic operation successfully. Then we initiate the optical see-through technique in order to find solutions for these difficulties of laparoscopy. Methods: The floating display mechanism of optical see-through technique is proposed and deeply researched to overcome the mislocation of camera picture and the misorientation of instrument movements. The line-of-sight of endoscope is transformed and coincides with the surgeon's natural line-of-sight. The pictures of endoscope are projected onto the semi-transparent mirror between the surgeon's eyes and the abdomen, and the pre-operative information from X-ray, ultrasound or MRI images are also mapped onto the endoscope camera pictures, which gives the surgeon the visual sense of seeing through the skin. An experimental optical see-through system is constructed. Results: Extensive experiments are conducted on phantoms to verify the accuracy and stability of the constructed system. Experimental results show that the optical see-through system has better performance and overcomes the eye-hand coordination problem. Conclusions:The optical see-through system shows its superiority in laparoscopy, and has a broad application prospect in the future. We will develop its new functions for other kinds of surgeries such as arthroscopy. Its disadvantages such as complex calibration procedure have to be resolved in the future. College of Information System and Management, National University of Defense Technology, Changsha, Hunan, China Aims: One ubiquitous limitation of most previous studies in Health Monitoring Systems is they just focused on the architecture but disregard the acquired data. This manuscript try to obtain better monitor effect though an improved Statistical Process Control (SPC) control chart. Methods: Two groups of volunteers participated in the questionnaire. They had diabete or hypertension separately, and their living habits and environments were similar. Under the control of Minimum Mean Squared Error (MMSE), we can eliminate the influence of autocorrelation and cyclical change. The system would send timely warning signs by inputting the convert white noises to the Cumulative Sum (CUSUM) and Exponentially Weighted Moving-Average (EWMA) control chart. Results: Since the introduction of CUSUM and EWMA control chart, the system could detect the tiny changes of cumulating trend. In addition, it becomes more sensitive after the utilization of a positive feedback when the correlation of data is high. Conclusions: The system presented in this article bring better results, as the ability to get change of accumulation has more practical value in keeping healthy. The number of cases was inadequate, however, the correctness and validity of the improved method h...

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The Anyang Esophageal Cancer Cohort Study: Study Design, Implementation of Fieldwork, and Use of Computer-Aided Survey System

Cited by 37 publications

References 26 publications

Oral Human Papillomavirus Infection and Its Risk Factors among 5,410 Healthy Adults in China, 2009–2011

Oral Human Papillomavirus Infection and Its Risk Factors among 5,410 Healthy Adults in China, 2009–2011

Prevalence, Incidence, Clearance, and Associated Factors of Genital Human Papillomavirus Infection among Men: A Population-Based Cohort Study in Rural China

Abstracts of the Medical Engineering and Bioinformatics 2015 (MEB 2015), China, 7 June 2015

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