The aphrodisiac herb Tribulus terrestris does not influence the androgen production in young men

Neychev, Vladimir; Mitev, Vanio

doi:10.1016/j.jep.2005.05.017

Cited by 97 publications

(62 citation statements)

References 19 publications

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“…It can be concluded that TT has potential aphrodisiac activity on permethrin induced toxicity in goat testis. The present finding are contrary to the observation of Neychev and Mitev [31] who have reported that TT unable to increase the levels of androgenic hormones in young humans. Whereas the present observations are in agreement with the effected works by, Kumari and Singh…”

Section: Discussioncontrasting

confidence: 99%

Ameliorative Effects of Phytoandrogen and Antioxidant on Histoarchitecture of Permethrin Induced Changes in Goat Testis

Bhardwaj

Sharma

2017

Int J Pharm Pharm Sci

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Objective: Protective effects of Tribulus terrestris (TT) and vitamin C were studied against permethrin induced changes in the histoarchitecture of goat testis.Methods: Hydroalcoholic extract of the fruits of Tribulus terrestris was prepared by maceration method and the extractive value was calculated. Fresh stock solution of permethrin (1mg/ml) in dimethyl sulphoxide and Tribulus terrestris (1mg/ml) in distilled water were prepared. Testicular tissues were cultured in TCM-199 nutrition media at 39℃ with 95% humidity and 5% CO₂ in the CO₂ incubator. Cultured testicular tissue was grouped as control having only the nutritive media, experimental group I(EI) received two doses of permethrin (100µg/ml and 200µg/ml), experimental group II(EII) was administered doses of permethrin along with vitamin C(0.1µM/ml) and experimental group III(EIII) was supplemented with doses of permethrin along with Tribulus terrestris (100µg/ml). All the groups were tested for 4 hr. and 8hr. for histoarcitectural studies.Results: Histological alterations were observed such as distorted shape of seminiferous tubules, decreased luminal and interstitial space, reduction in the population of spermatocytes, spermatozoa and spermatids in treated (E1) group as compared to control group. Maximum damage was detected at a higher dose of permethrin (200µg/ml) for 8h in contrast to lower doses (100 4h and 8h). Thus, it is concluded that permethrin has both dose and timedependent effects. Protective groups (E2 and E3) imparted ameliorative effects by reestablishing shape of seminiferous tubules, decreasing luminal and interstitial space, increased population of spermatocyte, spermatozoa, and spermatids as compared with treated groups (E1) Conclusion: It has been reported that permethrin affects male fertility by inducing detrimental changes in the structure and function of seminiferous tubules. Both vitamin C and TT have the ability to mitigate the effect of pesticide. TT shows aphrodisiac activity against permethrin induced alterations in goat testis.

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Section: Discussioncontrasting

confidence: 99%

Ameliorative Effects of Phytoandrogen and Antioxidant on Histoarchitecture of Permethrin Induced Changes in Goat Testis

Bhardwaj

Sharma

2017

Int J Pharm Pharm Sci

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“…However, some studies have contradicted these effects, showing no effects when administered the herbal extracts or preparations from this species. Neychev and Mitev (2005)found that T. terrestris was not able to increase the levels of androgenic hormones in young humans. Thus, the results involving the effectiveness of this plant are still uncertain and controversial.…”

Section: Introductionmentioning

confidence: 97%

Sperm Quality and Testicular Histomorphometry of Wistar Rats Supplemented with Extract and Fractions of Fruit of Tribulus terrestris L.

Oliveira

Félix

Pereira

et al. 2015

Braz. arch. biol. technol.

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“…Saponin in T. terrestris thought to be responsible for its effect on testosterone levels is known as protodioscin (Ganzera, Bedir, & Khan, 2001). It is believed that T. terrestris affects androgen metabolism, significantly increasing testosterone or testosterone precursor levels (Neychev & Mitev, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Sotoudeh¹,

Movaffagh²

2017

Turk. J. Fish. Aquat. Sci.

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This study evaluated the effects of diet containing 1 and 2 g kg -1 T. terrestris extract on growth and reproductive performance of male Convict cichlid (C. nigrofasciatum). 117 male C. nigrofasciatum with an average initial weight of 2.30 ± 0.04 g were distributed into glass aquariums (13 fish/tank) in 3 replicates. The highest weight gain was obtained in 1 g kg -1 (123.83 ± 6.41 g) followed by 2 g kg -1 extract (121.13 ± 8.09 g) and control (80.10 ± 11.71 g) group (P< 0.05). In groups that received extract, specific growth rate increased significantly (P< 0.05). Comparison of feed conversion ratio and condition factor in different treatments indicates no significant differences (P> 0.05). Protein levels of dried body decreased after feeding the fish with extract (P< 0.05). Fish fed with extract showed higher lipid and moisture content than fish fed by control diet (P< 0.05). The highest belly diameter was observed in treatment containing 1 g kg -1 extract (9.93 ± 0.23 cm, P< 0.05). Fertilization (%) decreased significantly in 2 g kg -1extract when compared with control and other group (P< 0.05). The highest amount of hatching rate (%) was observed in 1 g kg -1(94.24 ± 3.01) and its least amount was found in 2 g kg -1 extract (72.65 ± 0.23, P> 0.05).

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The aphrodisiac herb Tribulus terrestris does not influence the androgen production in young men

Cited by 97 publications

References 19 publications

Ameliorative Effects of Phytoandrogen and Antioxidant on Histoarchitecture of Permethrin Induced Changes in Goat Testis

Ameliorative Effects of Phytoandrogen and Antioxidant on Histoarchitecture of Permethrin Induced Changes in Goat Testis

Sperm Quality and Testicular Histomorphometry of Wistar Rats Supplemented with Extract and Fractions of Fruit of Tribulus terrestris L.

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