The APLAR Gout Registry: A multinational collaboration to better understand people with gout in the Asia‐Pacific

Jatuworapruk, Kanon; Vera, Ruth; Estrella, Ana; Sollano, Ma Hanna Monica Z.; Vaidya, Binit; Rahman, Md. Mujibur; Lim, Ai Lee; Manuaba, Ida Ayu Ratih Wulansari; Hellmi, Rakhma Yanti; Keen, Helen; Lorenzo, Jose Paulo

doi:10.1111/1756-185x.14765

Cited by 6 publications

(4 citation statements)

References 13 publications

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“…Although the questions in the TIQ‐20 appeared to be universal, both its development and recent test of responsiveness to ULT were conducted in cohorts from Aotearoa/New Zealand. It would be prudent to validate the TIQ‐20 in other populations, preferably those with different socioeconomic and cultural backgrounds, as these factors strongly contribute to the characteristics, treatment outcomes, and healthcare access for individuals living with gout 19 . The high prevalence of gout in Aotearoa/New Zealand may have influenced disease perception and response to the questionnaire due to the population's greater familiarity with the concept of gout compared to areas with lower gout prevalence 20 .…”

Section: Challenges and Future Research Directionmentioning

confidence: 99%

Toward a holistic tophus assessment in gout clinical trials: What lies beyond tophus count and size?

Jatuworapruk

2024

Int J of Rheum Dis

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Section: Challenges and Future Research Directionmentioning

confidence: 99%

Toward a holistic tophus assessment in gout clinical trials: What lies beyond tophus count and size?

Jatuworapruk

2024

Int J of Rheum Dis

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“…A recent study reporting the burden of gout and its attributable risk factors in the Middle East and North Africa region between 1990 and 2019 has shown an 11.1% increase on annual incidence rates of gout with a positive association with the sociodemographic index (6). An increased burden of gout has also been encountered in Asia-Pacific countries and prompted the Asia Pacific League of Associations for Rheumatology (APLAR) to create a longitudinal, multinational physician-reported registry of people with gout living in these countries (7). The aim of this registry is to increase the knowledge about gout and how to manage it in the Asia-Pacific regions.…”

Section: Epidemiology and Diagnosismentioning

confidence: 99%

Gout: one year in review 2023

Punzi,

Galozzi,

Luisetto

et al. 2024

Clinical and Experimental Rheumatology

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Gout is a chronic joint disease caused by the deposition of monosodium urate crystals into and around the articular tissues. In the last two years, new insights regarding diagnosis, genetic involvement, pathogenesis, comorbidities, and clinical data, have allowed the identification of new strategies to improve the control of the disease and its flares. In keeping, the discover of new mechanisms concerning crystalinduced inflammation have suggested new ways for the management not only of gout, but also other systemic diseases, mainly including renal and cardiovascular disorders. In this context it is very representative the case of colchicine which, given the surprising results obtained both in laboratory and clinical experiments, has recently received by FDA the approval for the prevention of cardiovascular disorders.

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“…Despite the high prevalence of this disease, existing gout registers predominantly come from rheumatology settings 6 7 which do not fully capture the disease’s spectrum. 8 One of the barriers to create larger gout registers is their labour-intensive nature, requiring manual data collection by healthcare professionals. Furthermore, administrative datasets, a common source for research studies, often lack relevant clinical information such as laboratory data and specific patient-centred outcomes.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a self-updating gout register from electronic health records data

Bürgisser,

Mongin,

Mehouachi

et al. 2024

RMD Open

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ObjectiveTo develop an automatic gout register from electronic health records (EHRs) data.MethodsWe analysed the EHR of all patients >18 years old from a tertiary academic hospital (2013–2022) based on six criteria: International Classification of Diseases 10 gout diagnosis, urate-lowering therapy prescription, monosodium urate crystals in joint aspiration and gout-related terms in problem lists, clinical or imaging reports. We assessed the positive and negative predictive value (PPV and NPV) of the query by chart reviews.ResultsOf 2 110 902 outpatients and inpatients, 10 289 had at least one criterion for gout. The combination of joint aspiration OR diagnostic in the problem list OR≥2 other criteria created a register of 5138 patients, with a PPV of 92.4% (95% CI 88.5% to 95.0%) and an NPV of 94.3% (95% CI 91.9% to 96.0%). PPV and NPV were similar among outpatients and inpatients. Incidence was 2.9 per 1000 person-year and dropped by 30% from the COVID-19 pandemic onward. Patients with gout were on average 71.2 years old (SD 14.9), mainly male (76.5%), overweight (69.5%) and polymorbid (mean number of comorbidities of 3, IQR 1–5). More than half (57.4%) had received a urate-lowering treatment, 6.7% had a gout that led to a hospitalisation or ≥2 flares within a year and 32.9% received a rheumatology consultation.ConclusionAn automatic EHR-based gout register is feasible, valid and could be used to evaluate and improve gout management. Interestingly, the register uncovered a marked underdiagnosis or under-reporting of gout since the COVID-19 pandemic.

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The APLAR Gout Registry: A multinational collaboration to better understand people with gout in the Asia‐Pacific

Cited by 6 publications

References 13 publications

Toward a holistic tophus assessment in gout clinical trials: What lies beyond tophus count and size?

Toward a holistic tophus assessment in gout clinical trials: What lies beyond tophus count and size?

Gout: one year in review 2023

Development and validation of a self-updating gout register from electronic health records data

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