The ApoAI-CIII-AIV gene cluster and its relation to lipid levels in type 2 diabetes mellitus and coronary heart disease: determination of a novel susceptible haplotype

Singh, Puneetpal; Singh, Monica; Gaur, Sunil; Kaur, Taranpal

doi:10.3132/dvdr.2007.030

Cited by 15 publications

(17 citation statements)

References 26 publications

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“…Other genes having roles in metabolism have been identified. APOA1 is the major component of high density lipoprotein in plasma and SNPs in APOA1 gene have been associated with the risk of cardiovascular diseases [141] and with T2D [142]. Zhang et al observed that the microbiota of APOA1 -deficient mice has a different community structure in comparison with that of wild-type mice [143].…”

Section: Gut Microbiota-host Genes Crosstalk and Role Of The Dietmentioning

confidence: 99%

The Three Genetics (Nuclear DNA, Mitochondrial DNA, and Gut Microbiome) of Longevity in Humans Considered as Metaorganisms

Garagnani

Pirazzini

Giuliani

et al. 2014

BioMed Research International

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Usually the genetics of human longevity is restricted to the nuclear genome (nDNA). However it is well known that the nDNA interacts with a physically and functionally separated genome, the mitochondrial DNA (mtDNA) that, even if limited in length and number of genes encoded, plays a major role in the ageing process. The complex interplay between nDNA/mtDNA and the environment is most likely involved in phenomena such as ageing and longevity. To this scenario we have to add another level of complexity represented by the microbiota, that is, the whole set of bacteria present in the different part of our body with their whole set of genes. In particular, several studies investigated the role of gut microbiota (GM) modifications in ageing and longevity and an age-related GM signature was found. In this view, human being must be considered as “metaorganism” and a more holistic approach is necessary to grasp the complex dynamics of the interaction between the environment and nDNA-mtDNA-GM of the host during ageing. In this review, the relationship between the three genetics and human longevity is addressed to point out that a comprehensive view will allow the researchers to properly address the complex interactions that occur during human lifespan.

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Section: Gut Microbiota-host Genes Crosstalk and Role Of The Dietmentioning

confidence: 99%

The Three Genetics (Nuclear DNA, Mitochondrial DNA, and Gut Microbiome) of Longevity in Humans Considered as Metaorganisms

Garagnani

Pirazzini

Giuliani

et al. 2014

BioMed Research International

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“…In the Indian population, rs12721026 was associated with increased risk for type II diabetes [48]. Our results showed an association of the rs1729408 C-allele and higher HbAc1 levels.…”

Section: Discussionmentioning

confidence: 44%

APOA1/A5Variants and Haplotypes as a Risk Factor for Obesity and Better Lipid Profiles in a Brazilian Elderly Cohort

Chen

Furuya

Mazzotti

et al. 2010

Lipids

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Genetic variations in the APOA1/C3/A4/A5 gene cluster have been studied and proposed to be the leading key for susceptibility to cardiovascular diseases and age-associated disorders. We aimed to investigate the associations of rs12721026 (APOA1) and rs1729408 (APOA5) polymorphisms and their haplotypes with some age-related diseases, as well as with lipids and proteins serum levels in a cohort from a Brazilian Elderly Longitudinal Study (EPIDOSO). Genotyping was performed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Statistical analyses were carried out using logistic regression analysis, Student's t-test, and linkage disequilibrium (LD) analysis. Polymorphic allele frequencies were 0.095 and 0.449 for rs12721026 and rs1729408, respectively. The C-allele of rs1729408 was associated with higher high-density lipoprotein (HDL) (P = 0.022) and glycated hemoglobin levels (P = 0.020). We also showed that rs12721026 and rs1729408 were in LD. The GC haplotype, which is composed of the G-allele of rs12721026 and the C-allele of rs1729408, was significantly associated with obesity (P = 0.028), with higher glycated hemoglobin (P = 0.006), and fasting glucose (P = 0.0003) compared to the TT haplotype, which includes the wild-type alleles of both polymorphisms. Moreover, we found an association between the TC haplotype and higher HDL levels (P = 0.0039). This is the first time that haplotypes involving these polymorphisms were evaluated. Our results showed that these polymorphisms were involved in the development of obesity and in alterations of lipids and proteins serum levels in a Brazilian population. The present findings might also clarify the role of these polymorphisms and their haplotypes in lipids and proteins metabolism.

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“…Subjects taking estrogens or having other affiliated diseases like renal and hepatic insufficiency were excluded. The details of study design were described elsewhere [6,7]. After DNA extraction with phenol chloroform, the genotypes of ApoE and ApoA-I/ 3′ flanking region were determined by PCR RFLP using the restriction enzymes HhaI and PstI respectively.…”

Section: Methodsmentioning

confidence: 99%

Role of apolipoproteins E and A-I: Epistatic villains of triglyceride mediation in coronary heart disease

Singh

Kaur³

2009

International Journal of Cardiology

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The ApoAI-CIII-AIV gene cluster and its relation to lipid levels in type 2 diabetes mellitus and coronary heart disease: determination of a novel susceptible haplotype

Cited by 15 publications

References 26 publications

The Three Genetics (Nuclear DNA, Mitochondrial DNA, and Gut Microbiome) of Longevity in Humans Considered as Metaorganisms

The Three Genetics (Nuclear DNA, Mitochondrial DNA, and Gut Microbiome) of Longevity in Humans Considered as Metaorganisms

APOA1/A5Variants and Haplotypes as a Risk Factor for Obesity and Better Lipid Profiles in a Brazilian Elderly Cohort

Role of apolipoproteins E and A-I: Epistatic villains of triglyceride mediation in coronary heart disease

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