The apolipoprotein A-I binding protein of placenta and the SP-40,40 protein of human blood are different proteins which both bind to apolipoprotein A-I

Ehnholm, Christian; Bozas, S.E.; Tenkanen, H; Kirszbaum, L.; Metso, Jari; Murphy, Brendan; Walker, Ian D.

doi:10.1016/0005-2760(91)90167-g

Cited by 11 publications

(4 citation statements)

References 19 publications

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“…Apo J is found in normal human plasma (1) where it associates with a high density lipoprotein (HDL) particle (3) that may also contain apo A-I (3)(4)(5) and cholesterol ester transfer protein (5). It is expressed in many tissues, especially liver, brain, ovary, and testis (2,6).…”

Section: Introductionmentioning

confidence: 99%

Endotoxin and cytokines increase hepatic messenger RNA levels and serum concentrations of apolipoprotein J (clusterin) in Syrian hamsters.

Harðardóttir

Kunitake²,

Moser³

et al. 1994

J. Clin. Invest.

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Infection and inflammation induce alterations in hepatic synthesis and plasma concentrations of the acute phase proteins. Our results show that apolipoprotein (apo) J is a positive acute phase protein. Endotoxin (LPS), tumor necrosis factor (TNF), and interleukin (IL)-1 increased hepatic mRNA and serum protein levels of apo J in Syrian hamsters. Hepatic apo J mRNA levels increased 10-to 15-fold with doses of LPS from 0.1 to 100 pg/100 g body weight within 4 h and were elevated for 2 24 h. Serum apo J concentrations were significantly increased by 16 h and further elevated to 3.3 times that of control, 24 h after LPS administration. Serum apo J was associated with high density lipoprotein and increased fivefold in this fraction, after LPS administration. Hepatic apo J mRNA levels increased 3.5-and 4.6-fold, with TNF and IL-1, respectively, and 8.2-fold with a combination of TNF and IL-1. Serum apo J concentrations were increased 2.3-fold by TNF, 79% by IL-1, and 2.9-fold with a combination of TNF and IL-1. These results demonstrate that apo J is a positive acute phase-protein. (J.

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Section: Introductionmentioning

confidence: 99%

Endotoxin and cytokines increase hepatic messenger RNA levels and serum concentrations of apolipoprotein J (clusterin) in Syrian hamsters.

Harðardóttir

Kunitake²,

Moser³

et al. 1994

J. Clin. Invest.

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“…Clusterin은 지질운송, 정자발생, 보체조절, 내분비 및 발생과정 중 다양한 조직의 분화와 관련이 있는 것으로 알려져 있으며, 또한 스트레스와 조직손상에 대해 보호하는 역할을 하는 것으로 추정된다 10) . 혈액 내의 clusterin은 대부분 clusterin-apoAl complex의 형태로 결합되어 있으며, 이 복합체는 지 질단백질 간의 콜레스테롤에스터 전이를 일으킨다 38,43) . high density lipoprotein(HDL)의 기능에 근거해 볼 때, clusterin은 세포 간의 지질 운송 역할을 할 뿐 만 아니라, 세포막의 안정, 재형성과 치유 등 세포완 전성을 유지하는 데 중요한 역할을 할 것으로 추측된 다 39) .…”

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The Effect of Repeated Restraint Stress on Clusterin Change of the Rat Salivary Glands

이고운¹,

강수경²,

전양현³

et al. 2012

Journal of Oral Medicine and Pain

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“…Clusterin is one of principal proteins in body fluids including plasma, urine and milk as well as semen. This protein interacts with APOA1 [77]. Clusterin is known to be expressed in a variety of tissues and it seems to be able to bind to the membranes and hydrophobic proteins.…”

Section: Breast Cancer Plasma and Proteomicsmentioning

confidence: 99%

LC-MS/MS proteomics analysis of biomarkers in Singapore breast cancer patients on doxorubicin treatment and MCF7 breast cancer derived cells

Rasouliha¹

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Breast cancer is known as the most common cancer in women population, especially in developed countries. Improved prognosis and effective treatment are needed to reduce the mortality of the disease. Doxorubicin, a topoisomerase II-targeting chemotherapeutic drug has been widely used to treat breast cancer. The rapidly evolved proteomics techniques, especially LC-MS/MS analysis, has been used in protein profiling in body fluids as well as cells, which provide us with a deep comprehension in drugs mechanism and patients response to the treatment. This new method can be extended in biomarker identification to improve diagnosis and monitoring of treatment. Effective treatment of breast cancer by Doxorubicin has been complicated by the single nucleotide polymorphism (SNP 309) in MDM 2 gene. The polymorphism is caused by substitution of Guanine over Thymine in its promoter. SNP 309 can be homozygous (GG) or heterozygous (TG) with different frequency in the general population. This polymorphism promotes tumor susceptibility and resistance to topoisomerase II-targeting agents. We aim to identify plasma proteins which correlate with a particular SNP309 genotype by using LC-MS/MS proteomics approach. The main objective of this research is to find the effective expressed biomarkers which should facilitate the monitoring of Doxorubicin treatment. Two different targets were selected in this study: 1) thirty breast cancer patients' on Doxorubicin treatment; 2) breast cancer-derived MCF7 cell line incubated with Doxorubicin. The plasma samples from the patients selected in this study were separated in three groups based on MDM2 single nucleotide polymorphism. The identified proteins from plasma samples with heterozygous (TG) and homozygous (GG) mutant genotypes were categorized in two groups: up-regulated proteins and downregulated proteins were identified with significant {p < 0.05) changes from the view of statistic. In the GG genotype group of samples, three proteins including a-1-antitrypsin, ceruloplasmin and Serotransferrin were up-regulated while hemoglobin subunit p and a2 macroglobulin were down regulated. In TG genotype group of samples, Serotransferrin, Apolipoprotein A-l and Clusterin were down-regulated whereas ceruloplasmin were up regulated. The protein profiling MCF7 cells incubated with Doxorubicin as compared with untreated MCF7 cells indicated that 10 cellular proteins were down-regulated and 13 others upregulated. These included HSP 90, glyceraldehyde-3-phosphate dehydrogenase, peroxiredoxin-1, and Calreticulin precursor. It is to be hoped that proteins identified in our study can be candidate biomarkers in monitoring Doxorubicin therapy in patients. 4

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The apolipoprotein A-I binding protein of placenta and the SP-40,40 protein of human blood are different proteins which both bind to apolipoprotein A-I

Cited by 11 publications

References 19 publications

Endotoxin and cytokines increase hepatic messenger RNA levels and serum concentrations of apolipoprotein J (clusterin) in Syrian hamsters.

Endotoxin and cytokines increase hepatic messenger RNA levels and serum concentrations of apolipoprotein J (clusterin) in Syrian hamsters.

The Effect of Repeated Restraint Stress on Clusterin Change of the Rat Salivary Glands

LC-MS/MS proteomics analysis of biomarkers in Singapore breast cancer patients on doxorubicin treatment and MCF7 breast cancer derived cells

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